Gene Page: TOP3B

Summary
GeneID  8940
Symbol  TOP3B
Synonyms  FLJ39376
Description  topoisomerase (DNA) III beta
See related  HGNC:11993|MIM:603582|Ensembl:ENSG00000100038|HPRD:04662|
Locus tag  -
Gene type  protein-coding
Map location  22q11.22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ACTR30.940.95
PSPC10.930.94
CCT50.930.93
GSPT20.920.94
ARF40.920.92
PLAA0.920.92
RAB100.920.92
YWHAQ0.920.93
ARMCX50.920.92
GLOD40.920.92
Top 10 negatively co-expressed genes
MT-CO2-0.81-0.86
AF347015.33-0.79-0.85
FXYD1-0.78-0.84
AF347015.31-0.78-0.84
AF347015.8-0.78-0.85
AF347015.27-0.76-0.84
MT-CYB-0.76-0.83
AF347015.21-0.75-0.84
AF347015.2-0.75-0.84
AF347015.15-0.74-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003917DNA topoisomerase type I activityIEA-
GO:0005515protein bindingIPI15231747 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006268DNA unwinding during replicationIEA-
GO:0006265DNA topological changeIEA-
GO:0007059chromosome segregationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000793condensed chromosomeIEA-
GO:0005634nucleusTAS9786843 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CENPFCENF | PRO1779 | hcp-1centromere protein F, 350/400ka (mitosin)-HPRD,BioGRID11549288 
CHD8DKFZp686N17164 | HELSNF1 | KIAA1564chromodomain helicase DNA binding protein 8-HPRD,BioGRID11549288 
CHIC2BTL | MGC21173cysteine-rich hydrophobic domain 2Two-hybridBioGRID16189514 
FBLN5ARMD3 | DANCE | EVEC | FIBL-5 | FLJ90059 | UP50fibulin 5-HPRD,BioGRID11549288 
GRNGEP | GP88 | PCDGF | PEPI | PGRNgranulinTwo-hybridBioGRID11549288 
KRTAP4-12KAP4.12 | KRTAP4.12keratin associated protein 4-12Two-hybridBioGRID16189514 
RECQL5FLJ90603 | RECQ5RecQ protein-like 5RecQ5-beta interacts with Top3-beta.BIND10710432 
-HPRD,BioGRID10710432 
SNRPBCOD | SNRPB1 | SmB/SmB' | snRNP-Bsmall nuclear ribonucleoprotein polypeptides B and B1-HPRD,BioGRID11549288 
ZFPM1FOG | FOG1 | ZNF408 | ZNF89Azinc finger protein, multitype 1-HPRD,BioGRID15231747 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HOMOLOGOUS_RECOMBINATION 2817All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP 13378All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE 4828All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP 4430All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
MATZUK_MEIOTIC_AND_DNA_REPAIR 3926All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway


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