Gene Page: CD2

Summary
GeneID  914
Symbol  CD2
Synonyms  SRBC|T11
Description  CD2 molecule
See related  HGNC:1639|MIM:186990|Ensembl:ENSG00000116824|HPRD:01750|
Locus tag  RP4-655N15.2
Gene type  protein-coding
Map location  1p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NAGS0.900.26
ZIC40.880.27
ZIC10.880.27
FZD100.870.20
ZIC20.840.24
PROX10.830.41
KRT18P190.800.13
GBX20.800.36
PGAM20.780.35
KITLG0.770.26
Top 10 negatively co-expressed genes
C20orf39-0.14-0.05
SLC26A4-0.14-0.13
BAIAP2-0.130.08
PIK3IP1-0.130.12
GRIA3-0.13-0.00
GTDC1-0.13-0.13
ADCY2-0.130.02
CRYM-0.13-0.14
CACNG3-0.12-0.01
KIAA1614-0.120.16
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityNAS7544493 
GO:0005515protein bindingIPI1970422 |7544493 |12356317 
GO:0005515protein bindingISS7544493 |12356317 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030887positive regulation of myeloid dendritic cell activationNASdendrite (GO term level: 9)12714509 
GO:0001766membrane raft polarizationTAS11376005 |11591762 
GO:0030101natural killer cell activationNAS12714509 
GO:0006917induction of apoptosisTAS9270771 |10575274 
GO:0007166cell surface receptor linked signal transductionTAS10575274 
GO:0016337cell-cell adhesionNAS7544493 
GO:0042110T cell activationTAS2471997 
GO:0045580regulation of T cell differentiationNAS11544295 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005887integral to plasma membraneNAS7544493 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD8977276 
CD2APCMS | DKFZp586H0519CD2-associated proteinReconstituted ComplexBioGRID12690097 
-HPRD9741631 
CD2BP2FWP010 | LIN1 | Snu40 | U5-52KCD2 (cytoplasmic tail) binding protein 2-HPRD,BioGRID9843987 
CD4CD4mutCD4 molecule-HPRD7539755 
CD48BCM1 | BLAST | BLAST1 | MEM-102 | SLAMF2 | hCD48 | mCD48CD48 molecule-HPRD,BioGRID12356317 
CD5LEU1 | T1CD5 molecule-HPRD,BioGRID10510361 
CD53MOX44 | TSPAN25CD53 molecule-HPRD,BioGRID1346273 
CD58LFA-3 | LFA3CD58 molecule-HPRD,BioGRID1377404 |11575926 
CD5916.3A5 | 1F5 | EJ16 | EJ30 | EL32 | FLJ38134 | FLJ92039 | G344 | HRF-20 | HRF20 | MAC-IP | MACIF | MEM43 | MGC2354 | MIC11 | MIN1 | MIN2 | MIN3 | MIRL | MSK21 | p18-20CD59 molecule, complement regulatory protein-HPRD1377404 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9677430 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinaseAffinity Capture-WesternBioGRID9677430 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID8551220 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1-HPRD,BioGRID10642604 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1-HPRD,BioGRID11602341 
PSTPIP1CD2BP1 | CD2BP1L | CD2BP1S | H-PIP | PAPAS | PSTPIPproline-serine-threonine phosphatase interacting protein 1-HPRD,BioGRID9857189 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID1970422 |1976695 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD12690097 
-HPRD,BioGRID9857189 |12690097|12690097 
SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2.BIND11152963 
SP1-Sp1 transcription factor-HPRD7933095 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_IL17_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_NO2IL12_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_STATHMIN_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_TCYTOTOXIC_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_THELPER_PATHWAY 1411All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_1 4423All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN 5529All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN 7749All SZGR genes in this pathway
FERRANDO_TAL1_NEIGHBORS 2115All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
YU_MYC_TARGETS_DN 5538All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_UP 2823All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7 9863All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_FOXP3_CORE_DIRECT_TARGETS 1914All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_UP 6643All SZGR genes in this pathway
ONO_AML1_TARGETS_DN 4125All SZGR genes in this pathway
CHIARETTI_T_ALL_RELAPSE_PROGNOSIS 1915All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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