Gene Page: CD3E

Summary
GeneID  916
Symbol  CD3E
Synonyms  FLJ18683|T3E|TCRE
Description  CD3e molecule, epsilon (CD3-TCR complex)
See related  HGNC:1674|MIM:186830|Ensembl:ENSG00000198851|HPRD:08923|
Locus tag  -
Gene type  protein-coding
Map location  11q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EXTL10.710.67
MAST30.700.63
ANXA110.690.68
EPB490.680.61
SYNPO0.680.66
KCNK10.680.67
DGKZ0.680.65
ADRB10.670.59
CAMK2A0.670.67
RASAL10.670.63
Top 10 negatively co-expressed genes
TUBB2B-0.43-0.52
GTF3C6-0.43-0.47
FAM36A-0.43-0.46
C9orf46-0.43-0.54
BCL7C-0.42-0.57
DYNLT1-0.42-0.61
KIAA1949-0.42-0.47
EXOSC8-0.42-0.53
PDE9A-0.42-0.52
YBX1-0.42-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityTAS1370449 
GO:0004888transmembrane receptor activityNAS9485181 
GO:0017124SH3 domain bindingIPI12110186 
GO:0030159receptor signaling complex scaffold activityNAS9886373 
GO:0042608T cell receptor bindingNAS11186279 
GO:0019901protein kinase bindingNAS12110186 
GO:0046982protein heterodimerization activityIPI9485181 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS8530500 
GO:0007172signal complex assemblyTAS8490660 
GO:0006461protein complex assemblyNAS9886373 
GO:0042981regulation of apoptosisNAS12567487 
GO:0042110T cell activationNAS12110186 
GO:0042102positive regulation of T cell proliferationIMP12110186 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexNASSynap (GO term level: 8)9485181 
GO:0009897external side of plasma membraneIDA11390434 
GO:0005886plasma membraneEXP11048639 |11827988 |15489916 
|17652306 
GO:0005886plasma membraneIDA11390434 
GO:0005887integral to plasma membraneNAS9485181 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD9485181 
CD3EAPASE-1 | CAST | MGC118851 | PAF49CD3e molecule, epsilon associated proteinAffinity Capture-Western
Reconstituted Complex		BioGRID10373416 
CD3GCD3-GAMMA | FLJ17620 | FLJ17664 | FLJ79544 | FLJ94613 | MGC138597 | T3GCD3g molecule, gamma (CD3-TCR complex)Affinity Capture-WesternBioGRID9582308 
CD79BB29 | IGBCD79b molecule, immunoglobulin-associated beta-HPRD7541024 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)Affinity Capture-WesternBioGRID11349123 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD11855827 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Reconstituted ComplexBioGRID12110186 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID12110186 
NCLC23 | FLJ45706nucleolinReconstituted ComplexBioGRID11115514 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID9312149 |11689561 
|11855827 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD11855827 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseReconstituted ComplexBioGRID7761456 
TOP2BTOPIIB | top2betatopoisomerase (DNA) II beta 180kDa-HPRD,BioGRID8626450 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD9485181 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDaReconstituted ComplexBioGRID7761456 
-HPRD11855827 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_PRIMARY_IMMUNODEFICIENCY 3528All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_CTL_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_TCAPOPTOSIS_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_IL17_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_IL12_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_TCRA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_NO2IL12_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_TOB1_PATHWAY 2114All SZGR genes in this pathway
BIOCARTA_STATHMIN_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_TCYTOTOXIC_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_THELPER_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY 2118All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS 1615All SZGR genes in this pathway
REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE 1414All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_PD1_SIGNALING 1814All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
FERRANDO_TAL1_NEIGHBORS 2115All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_DN 4528All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN 7657All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_DN 1816All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_UP 159All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway


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