Gene Page: DGKI

Summary
GeneID  9162
Symbol  DGKI
Synonyms  DGK-IOTA
Description  diacylglycerol kinase, iota
See related  HGNC:2855|MIM:604072|Ensembl:ENSG00000157680|HPRD:07238|
Locus tag  -
Gene type  protein-coding
Map location  7q32.3-q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RBM390.940.95
TIA10.940.93
PRPF38B0.930.89
SF3B10.920.93
HNRPDL0.920.91
PNN0.920.92
LUC7L20.910.95
RSRC20.910.91
UPF3B0.900.89
ZMYM50.900.90
Top 10 negatively co-expressed genes
TNFSF12-0.65-0.72
AF347015.31-0.65-0.86
PTH1R-0.65-0.77
IFI27-0.64-0.85
TSC22D4-0.64-0.80
HLA-F-0.64-0.74
AIFM3-0.64-0.75
MT-CO2-0.63-0.84
AF347015.27-0.62-0.81
ALDOC-0.62-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004143diacylglycerol kinase activityTAS9830018 
GO:0005515protein bindingIPI17986458 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007205activation of protein kinase C activityIEA-
GO:0007242intracellular signaling cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS9830018 
GO:0005737cytoplasmTAS9830018 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCEROLIPID_METABOLISM 4926All SZGR genes in this pathway
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 7735All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 7656All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS 2517All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1013893951Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/1078318371Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-1443893951Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-226268m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-493-5p1611681A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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