Gene Page: DLGAP1

Summary
GeneID  9229
Symbol  DLGAP1
Synonyms  DAP-1|DAP-1-ALPHA|DAP-1-BETA|GKAP|MGC88156|SAPAP1|hGKAP
Description  discs, large (Drosophila) homolog-associated protein 1
See related  HGNC:2905|MIM:605445|Ensembl:ENSG00000170579|HPRD:09260|
Locus tag  -
Gene type  protein-coding
Map location  18p11.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SPTLC10.750.73
MRPL190.750.71
PAIP20.740.72
SCP20.730.71
RABL30.720.70
CEPT10.720.69
PCNP0.720.67
TBC1D150.710.66
ADK0.710.72
C6orf2110.710.70
Top 10 negatively co-expressed genes
AL022328.1-0.40-0.37
AC135724.1-0.39-0.41
IL32-0.39-0.22
AF347015.18-0.38-0.15
CXCL1-0.36-0.30
AF347015.21-0.35-0.06
FAM159B-0.34-0.17
RP9P-0.34-0.29
C10orf108-0.34-0.30
AC010300.1-0.33-0.24
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingTAS9024696 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionNASneuron, Synap, Neurotransmitter (GO term level: 6)9286858 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coli-HPRD,BioGRID9286858 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID9286858 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID9286858 
hDLG interacts with DAP-1alpha.BIND9286858 
DLGAP1 (GKAP) interacts with DLG1 (SAP97).BIND15729360 
hDLG interacts with DAP-1beta.BIND9286858 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)DAP-1 interacts with Chapsyn-110.BIND11122378 
Affinity Capture-WesternBioGRID10844022 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)Two-hybridBioGRID9115257 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-Western
Co-fractionation
Far Western
Reconstituted Complex
Two-hybrid		BioGRID9024696 |9115257 
|9286858 |10527873 
|10844022 |11060025 
-HPRD9024696 |9286858 
PSD-95 interacts with DAP-1alpha.BIND9286858 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10844022 
DAP-1 interacts with DLC-1.BIND11122378 
DLC8 interacts with GKAP. This interaction was modeled on a demonstrated interaction between DLC8 from an unspecified species and human GKAP.BIND11148209 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2DAP-1 interacts with DLC-2.BIND11122378 
-HPRD,BioGRID10844022 
GRIN2ANMDAR2A | NR2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A-HPRD,BioGRID9286858 
KCNA4HBK4 | HK1 | HPCN2 | HUKII | KCNA4L | KCNA8 | KV1.4 | PCN2potassium voltage-gated channel, shaker-related subfamily, member 4-HPRD9024696 
MYO5AGS1 | MYH12 | MYO5 | MYR12myosin VA (heavy chain 12, myoxin)Reconstituted ComplexBioGRID10844022 
SHANK1SPANK-1 | SSTRIP | synamonSH3 and multiple ankyrin repeat domains 1Co-crystal StructureBioGRID12954649 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2-HPRD,BioGRID10527873 
SHANK3KIAA1650 | PROSAP2 | PSAP2 | SPANK-2SH3 and multiple ankyrin repeat domains 3Two-hybridBioGRID10527873 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2-HPRD,BioGRID10521485 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 4936All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME2 1711All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED 228119All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-146335341m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-423210216m8hsa-miR-423AGCUCGGUCUGAGGCCCCUCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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