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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NRXN1

Summary

GeneID

9378

Symbol

NRXN1

Synonyms

DKFZp313P2036|FLJ35941|Hs.22998|KIAA0578

Description

neurexin 1

Locus tag

Gene type

protein-coding

Map location

2p16.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PSMA1

0.90

0.87

MRPS35

0.89

0.85

OLA1

0.88

0.86

ORC5L

0.87

0.85

STRAP

0.87

0.84

COPS3

0.86

0.82

SKP1

0.86

0.84

COPS4

0.86

0.85

AZI2

0.85

0.83

PMPCB

0.85

0.80

Top 10 negatively co-expressed genes

AF347015.2

-0.69

-0.59

AF347015.26

-0.68

-0.60

AF347015.8

-0.67

-0.57

AF347015.15

-0.65

-0.56

MT-CYB

-0.65

-0.56

MT-CO2

-0.65

-0.54

AF347015.18

-0.64

-0.63

AF347015.33

-0.64

-0.56

AF347015.31

-0.60

-0.52

AF347015.27

-0.60

-0.53

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

TAS

1621094

GO:0005509

calcium ion binding

IEA

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

11152476

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007411

axon guidance

TAS

axon (GO term level: 13)

1621094

GO:0007155

cell adhesion

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

GO:0005887

integral to plasma membrane

TAS

1621094

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	-	HPRD,BioGRID	11036064
APBA2	D15S1518E \| HsT16821 \| LIN-10 \| MGC99508 \| MGC:14091 \| MINT2 \| X11L	amyloid beta (A4) precursor protein-binding, family A, member 2	-	HPRD,BioGRID	11036064
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	-	HPRD,BioGRID	11036064
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8		-	HPRD	8786425
MACF1	ABP620 \| ACF7 \| FLJ45612 \| FLJ46776 \| KIAA0465 \| KIAA1251 \| MACF \| OFC4	microtubule-actin crosslinking factor 1	-	HPRD	12421765
MLLT4	AF-6 \| AF6 \| AFADIN \| FLJ34371 \| RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Two-hybrid	BioGRID	9707552
MYO16	KIAA0865 \| MYR8 \| Myo16b	myosin XVI	-	HPRD	12421765
NLGN1	KIAA1070 \| MGC45115	neuroligin 1	-	HPRD,BioGRID	8576240 \|14522992
NLGN2	KIAA1366	neuroligin 2	-	HPRD,BioGRID	8576240
NLGN3	ASPGX1 \| AUTSX1 \| HNL3 \| KIAA1480	neuroligin 3	-	HPRD	8576240 \|9325340
NLGN3	ASPGX1 \| AUTSX1 \| HNL3 \| KIAA1480	neuroligin 3	-	HPRD,BioGRID	8576240
NXPH1	NPH1 \| Nbla00697	neurexophilin 1	-	HPRD	8699246
NXPH1	NPH1 \| Nbla00697	neurexophilin 1	-	HPRD	9856994
NXPH2	MGC125477 \| MGC125478 \| MGC125479 \| MGC125480 \| NPH2	neurexophilin 2	-	HPRD	8699246
NXPH3	NPH3	neurexophilin 3	-	HPRD	9856994
PDZD2	AIPC \| KIAA0300 \| PAPIN \| PDZK3 \| PIN1	PDZ domain containing 2	-	HPRD	12421765
RPH3A	KIAA0985	rabphilin 3A homolog (mouse)	-	HPRD	8901523
SDCBP	MDA-9 \| ST1 \| SYCL \| TACIP18	syndecan binding protein (syntenin)	Neurexin I-alpha interacts with ST-1. This interaction was modelled on a demonstrated interaction between human neurexin I-alpha and rat ST-1.	BIND	11152476
SDCBP2	FLJ12256 \| SITAC18 \| ST-2	syndecan binding protein (syntenin) 2	-	HPRD	11152476
SIPA1L1	DKFZp686G1344 \| E6TP1 \| KIAA0440	signal-induced proliferation-associated 1 like 1	-	HPRD	12421765
SYT1	DKFZp781D2042 \| P65 \| SVP65 \| SYT	synaptotagmin I	-	HPRD	8901523 \|11243866
SYT13	KIAA1427	synaptotagmin XIII	-	HPRD,BioGRID	11171101
SYT2	SytII	synaptotagmin II	-	HPRD	8901523
SYT4	HsT1192 \| KIAA1342	synaptotagmin IV	-	HPRD	8901523
SYT5	-	synaptotagmin V	-	HPRD	8901523
SYT6	-	synaptotagmin VI	-	HPRD	8901523
SYT7	IPCA-7 \| MGC150517 \| PCANAP7 \| SYT-VII	synaptotagmin VII	-	HPRD	8901523
SYT9	FLJ45896	synaptotagmin IX	-	HPRD	8901523
SYTL1	FLJ14996 \| JFC1 \| SLP1	synaptotagmin-like 1	-	HPRD	11243866
SYTL2	CHR11SYT \| KIAA1597 \| MGC102768 \| SGA72M \| SLP2	synaptotagmin-like 2	-	HPRD	11243866
SYTL3	MGC105130 \| MGC118883 \| MGC118884 \| MGC118885 \| SLP3	synaptotagmin-like 3	-	HPRD	11243866

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CELL_ADHESION_MOLECULES_CAMS	134	93	All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP	408	247	All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP	146	99	All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN	291	176	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN	1375	806	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP	26	16	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
LU_AGING_BRAIN_DN	153	120	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL	254	164	All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_UP	18	16	All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP	282	183	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP	461	298	All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP	476	285	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN	546	362	All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3	718	401	All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3	445	257	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP	139	93	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B	549	316	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY	1725	838	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	1528	1534	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1528	1534	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-128	779	785	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	779	785	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-129-5p	188	194	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-141/200a	230	236	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	230	236	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-181	1022	1029	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-196	377	383	1A	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	377	383	1A	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-218	88	94	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-23	636	643	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	636	643	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-27	779	785	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	779	785	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-323	636	642	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-326	438	444	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-328	205	211	1A	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-33	817	823	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	817	823	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-335	163	169	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-339	105	112	1A,m8	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-377	1111	1117	1A	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	22	29	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	22	29	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	747	753	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-455	90	96	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-485-3p	1018	1025	1A,m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-485-3p	1018	1025	1A,m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-96	1326	1332	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.