Gene Page: GRAP2

Summary
GeneID  9402
Symbol  GRAP2
Synonyms  GADS|GRAP-2|GRB2L|GRBLG|GRID|GRPL|GrbX|Grf40|Mona|P38
Description  GRB2-related adaptor protein 2
See related  HGNC:4563|MIM:604518|Ensembl:ENSG00000100351|HPRD:05156|
Locus tag  RP3-370M22.1
Gene type  protein-coding
Map location  22q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0078 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA13050.940.92
ADAMTS70.940.91
DCHS10.930.93
DNMT3B0.930.87
LPAR20.930.85
PLXNB20.920.93
NINL0.920.92
AC145098.20.920.85
MICAL10.920.88
PLXNA30.910.88
Top 10 negatively co-expressed genes
C5orf53-0.65-0.74
FBXO2-0.64-0.64
HLA-F-0.64-0.66
ACOT13-0.63-0.72
ALDOC-0.63-0.61
FAM162A-0.62-0.73
ACYP2-0.62-0.70
LDHD-0.62-0.58
AIFM3-0.62-0.58
CA4-0.62-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityTAS9878555 
GO:0005515protein bindingIPI12359715 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007267cell-cell signalingTAS9878555 
GO:0007265Ras protein signal transductionTAS9878555 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP11048639 |11607830 |17652306 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS9878555 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BEND5C1orf165 | FLJ11588BEN domain containing 5Two-hybridBioGRID16189514 
CCNDBP1DIP1 | GCIPcyclin D-type binding-protein 1-HPRD,BioGRID10801854 
CD28MGC138290 | Tp44CD28 molecule-HPRD,BioGRID10820259 
GRAP2 (GRID) interacts with CD28.BIND10820259 
CSF1RC-FMS | CD115 | CSFR | FIM2 | FMScolony stimulating factor 1 receptorReconstituted ComplexBioGRID9857184 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2An unspecified isoform of Dyn2 interacts with Gads. This interaction was modeled on a demonstrated interaction between human Dyn2 and Gads from an unspecified species.BIND15696170 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD,BioGRID11741599 
GAB1-GRB2-associated binding protein 1-HPRD,BioGRID9878555 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD11997510 
GAB3-GRB2-associated binding protein 3-HPRD11997510 
GFAPFLJ45472glial fibrillary acidic proteinTwo-hybridBioGRID16189514 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1GRAP2 (GRID) interacts with GNB2L1 (RACK-1).BIND10820259 
-HPRD,BioGRID10820259 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KTwo-hybridBioGRID16189514 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1GRAP2 (GRID) interacts with KHDRBS1 (Sam68).BIND10820259 
-HPRD,BioGRID9872323 |10820259 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD9872323 
KRTAP4-12KAP4.12 | KRTAP4.12keratin associated protein 4-12Two-hybridBioGRID16189514 
LATLAT1 | pp36linker for activation of T cells-HPRD,BioGRID10021361 
LAX1FLJ20340 | LAXlymphocyte transmembrane adaptor 1Affinity Capture-WesternBioGRID12359715 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD,BioGRID10021361 |10224278 
SLP-76 interacts with Gads.BIND10021361 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1Grap2, a hematopoietic, Grb2-related adaptor protein interacts with HPK1, a Ste20-related serine/threonine kinaseBIND11313918 
-HPRD,BioGRID11313918 
PRPH2AOFMD | AVMD | PRPH | RDS | RP7 | TSPAN22 | rd2peripherin 2 (retinal degeneration, slow)-HPRD11641407 
RBPMSHERMESRNA binding protein with multiple splicingTwo-hybridBioGRID16189514 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD12084069 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD9872323 
SOS2FLJ25596son of sevenless homolog 2 (Drosophila)-HPRD,BioGRID10820259 
GRAP2 (GRID) interacts with Sos2.BIND10820259 
STAMBPAMSH | MGC126516 | MGC126518STAM binding protein-HPRD,BioGRID10224278 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideTwo-hybridBioGRID16189514 
ZBTB7BDKFZp686G01254 | THPOK | ZBTB15 | ZFP67 | ZNF857B | c-Krox | hcKroxzinc finger and BTB domain containing 7BTwo-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
PID_KIT_PATHWAY 5240All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION 3226All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN 10459All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
HUI_MAPK14_TARGETS_UP 2111All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway


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