Gene Page: GABBR2

Summary
GeneID  9568
Symbol  GABBR2
Synonyms  FLJ36928|GABABR2|GPR51|GPRC3B|HG20|HRIHFB2099
Description  gamma-aminobutyric acid (GABA) B receptor, 2
See related  HGNC:4507|MIM:607340|Ensembl:ENSG00000136928|HPRD:09552|
Locus tag  -
Gene type  protein-coding
Map location  9q22.1-q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IGSF30.940.96
XPR10.940.96
BCL11A0.940.88
AFF30.940.92
MLLT40.940.95
NFYA0.930.91
EML10.930.92
GPR120.920.92
ITSN10.920.89
TBR10.920.80
Top 10 negatively co-expressed genes
SERPINB6-0.67-0.77
C5orf53-0.64-0.80
HLA-F-0.63-0.80
HEPN1-0.62-0.78
TSC22D4-0.62-0.83
TNFSF12-0.62-0.68
AIFM3-0.62-0.78
HSD17B14-0.62-0.81
S100B-0.61-0.87
FXYD1-0.61-0.91
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004965GABA-B receptor activityTASGABA, glutamate (GO term level: 7)10328880 
GO:0004872receptor activityIEA-
GO:0004930G-protein coupled receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9872316 
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9872316 
GO:0007194negative regulation of adenylate cyclase activityTAS10328880 
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS10328880 
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF4CREB-2 | CREB2 | TAXREB67 | TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)-HPRD,BioGRID11087824 
ATF5ATFX | FLJ34666 | HMFN0395activating transcription factor 5-HPRD,BioGRID11087824 
GABBR1FLJ92613 | GABAB(1e) | GABABR1 | GABBR1-3 | GPRC3A | dJ271M21.1.1 | dJ271M21.1.2 | hGB1agamma-aminobutyric acid (GABA) B receptor, 1GB1 interacts with GB2.BIND15660124 
-HPRD,BioGRID9872316 
HTR1A5-HT1A | 5HT1a | ADRB2RL1 | ADRBRL15-hydroxytryptamine (serotonin) receptor 1A5-HT1A interacts with GABAB2. This interaction was modeled on a demonstrated interaction between 5-HT1A and GABAB2 from an unspecified species.BIND11854302 
SH3GL3CNSA3 | EEN-2B-L3 | EEN-B2 | HsT19371 | SH3D2C | SH3P13SH3-domain GRB2-like 3Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS 1511All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 2517All SZGR genes in this pathway
REACTOME_GABA_B_RECEPTOR_ACTIVATION 3826All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 3120All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN 244147All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_DN 4828All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_DN 3924All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_DN 5940All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_UP 6740All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_UP 4122All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_UP 3320All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_UP 4429All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_2 4231All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53 10963All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
CROONQUIST_STROMAL_STIMULATION_UP 6042All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12819131919m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-129-5p2882951A,m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-139205020561Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-17-5p/20/93.mr/106/519.d8908971A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-192/215186018661Ahsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-200bc/42919261932m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-204/211199320001A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2216371643m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-326146014671A,m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-370207320791Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-378168316901A,m8hsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-4502882941Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-452229523011Ahsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-9967973m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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