Gene Page: NCOR1

Summary
GeneID  9611
Symbol  NCOR1
Synonyms  KIAA1047|MGC104216|N-CoR|TRAC1|hCIT529I10|hN-CoR
Description  nuclear receptor co-repressor 1
See related  HGNC:7672|MIM:600849|Ensembl:ENSG00000141027|HPRD:02911|
Locus tag  -
Gene type  protein-coding
Map location  17p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0356 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
B4GALNT40.860.85
C7orf510.850.88
HDAC50.840.86
ZGPAT0.830.81
FBXL190.830.88
OGFR0.830.82
AC005077.30.830.80
NOVA20.820.84
PPAN0.820.81
SPIRE20.820.86
Top 10 negatively co-expressed genes
AF347015.31-0.68-0.74
MT-CO2-0.64-0.72
AF347015.27-0.64-0.72
MT-CYB-0.63-0.70
AF347015.33-0.62-0.68
B2M-0.62-0.70
HIGD1B-0.61-0.72
AF347015.21-0.61-0.73
AF347015.8-0.61-0.69
COPZ2-0.60-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0003677DNA bindingIEA-
GO:0003700transcription factor activityIEA-
GO:0003714transcription corepressor activityTAS7566114 
GO:0005515protein bindingIPI12590135 |14525983 |14667819 
GO:0016564transcription repressor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006366transcription from RNA polymerase II promoterTAS7566114 
GO:0016568chromatin modificationIEA-
GO:0045892negative regulation of transcription, DNA-dependentIEA-
GO:0045449regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID12089345 
BCL6BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51B-cell CLL/lymphoma 6-HPRD,BioGRID10898795 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3Affinity Capture-WesternBioGRID11533236 
CCL3G0S19-1 | LD78ALPHA | MIP-1-alpha | MIP1A | SCYA3chemokine (C-C motif) ligand 3NcoR interacts with the CCL3 promoter region.BIND15531890 
CCND2KIAK0002 | MGC102758cyclin D2NcoR interacts with the CCND2 promoter region.BIND15531890 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeNCOR1 (N-CoR) interacts with the CD82 (KAI1) promoter.BIND15829968 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)NCOR1 (N-CoR) interacts with p-p14(ARF) (p14(ARF) promoter).BIND15729358 
CHD1DKFZp686E2337chromodomain helicase DNA binding protein 1-HPRD,BioGRID12890497 
CLK1CLK | CLK/STY | STYCDC-like kinase 1Two-hybridBioGRID12890497 
CORO2ACLIPINB | DKFZp686G19226 | IR10 | WDR2coronin, actin binding protein, 2AAffinity Capture-MS
Affinity Capture-Western
BioGRID12628926 |14527417 
DACH1DACH | FLJ10138dachshund homolog 1 (Drosophila)-HPRD14525983 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)NCOR1 (NCoR) interacts with the ERBB2 (HER2) promoter.BIND15788656 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID12145334 
ESR1 (ER-alpha) interacts with NCOR1 (N-CoR). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and human NCOR1.BIND12738788 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)NCOR1 (NCoR) interacts with ETS1.BIND15788656 
ETS2ETS2IT1v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)NCOR1 (NCoR) interacts with ETS2.BIND15788656 
GPS2AMF-1 | MGC104294 | MGC119287 | MGC119288 | MGC119289G protein pathway suppressor 2-HPRD,BioGRID11931768 
N-CoR interacts with GPS2.BIND12628926 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Co-purification
Reconstituted Complex
Two-hybrid
BioGRID10944117 |11013263 
|11466315 |11804585 
|11931768 |12628926 
|14527417 
N-CoR interacts with HDAC3.BIND12628926 
-HPRD10944117 |11509652 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD10944117 |11804585 
Affinity Capture-Western
Reconstituted Complex
BioGRID10640275 |11804585 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5-HPRD,BioGRID10640275 
HDAC7DKFZp586J0917 | FLJ99588 | HD7A | HDAC7Ahistone deacetylase 7Affinity Capture-Western
Reconstituted Complex
BioGRID11466315 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9Affinity Capture-Western
Reconstituted Complex
BioGRID12590135 
HESX1ANF | MGC138294 | RPXHESX homeobox 1-HPRD11748154 
HEY2CHF1 | GRIDLOCK | GRL | HERP1 | HESR2 | HRT2 | MGC10720 | bHLHb32hairy/enhancer-of-split related with YRPW motif 2-HPRD,BioGRID11486045 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4Affinity Capture-MSBioGRID14527417 
HTTHD | IT15huntingtinHD interacts with N-CoR.BIND10441327 
Two-hybridBioGRID10441327 
JMJD2AJHDM3A | JMJD2 | KDM4A | KIAA0677jumonji domain containing 2AAffinity Capture-MSBioGRID14527417 
KIF11EG5 | HKSP | KNSL1 | TRIP5kinesin family member 11Affinity Capture-MSBioGRID14527417 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID12150997 
MECP2AUTSX3 | DKFZp686A24160 | MRX16 | MRX79 | MRXS13 | MRXSL | PPMX | RTS | RTTmethyl CpG binding protein 2 (Rett syndrome)-HPRD,BioGRID11441023 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1Reconstituted ComplexBioGRID10406466 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1Reconstituted ComplexBioGRID12569182 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2Co-fractionationBioGRID10944117 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Affinity Capture-WesternBioGRID12150997 
NR1D1EAR1 | THRA1 | THRAL | ear-1 | hRevnuclear receptor subfamily 1, group D, member 1-HPRD,BioGRID8948627 |9482666 
NR1D2BD73 | EAR-1r | HZF2 | Hs.37288 | RVRnuclear receptor subfamily 1, group D, member 2-HPRD,BioGRID8948627 |9482666 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID12011091 
NR6A1GCNF | GCNF1 | NR61 | RTRnuclear receptor subfamily 6, group A, member 1-HPRD10940306 
PDCD2MGC12347 | RP8 | ZMYND7programmed cell death 2-HPRD,BioGRID12149646 
PHBPHB1prohibitin-HPRD,BioGRID12466959 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID11430826 
PPARAMGC2237 | MGC2452 | NR1C1 | PPAR | hPPARperoxisome proliferator-activated receptor alpha-HPRD,BioGRID10336495 
PPARDFAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARBperoxisome proliferator-activated receptor deltaTwo-hybridBioGRID11867749 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD,BioGRID12634383 
RARANR1B1 | RARretinoic acid receptor, alphaNCOR1 (N-CoR) interacts with p-RAR-alpha2 (RAR-alpha2 promoter).BIND15729358 
Reconstituted Complex
Two-hybrid
BioGRID9531570 |10336495 
RARGNR1B3 | RARCretinoic acid receptor, gammaReconstituted Complex
Two-hybrid
BioGRID10336495 
RDBPD6S45 | NELF-E | RD | RDPRD RNA binding proteinTwo-hybridBioGRID14667819 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)-HPRD,BioGRID11113190 
ETO interacts with N-CoR.BIND15333839 
SAP30-Sin3A-associated protein, 30kDa-HPRD,BioGRID9702189 
SF3A1PRP21 | PRPF21 | SAP114 | SF3A120splicing factor 3a, subunit 1, 120kDaCo-purificationBioGRID11013263 
SF3B3KIAA0017 | RSE1 | SAP130 | SF3b130 | STAF130splicing factor 3b, subunit 3, 130kDaCo-purificationBioGRID11013263 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)-HPRD11013263 
Reconstituted ComplexBioGRID11430826 
SIRT1SIR2L1sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)Sirt1 interacts with NcoR.BIND15175761 
SKISKVv-ski sarcoma viral oncogene homolog (avian)Reconstituted ComplexBioGRID11430826 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Co-purificationBioGRID11013263 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Co-purificationBioGRID11013263 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Co-purificationBioGRID11013263 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Co-purificationBioGRID11013263 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)-HPRD11331609 
SRCAPDOMO1 | EAF1 | FLJ44499 | KIAA0309 | SWR1Snf2-related CREBBP activator proteinCo-purificationBioGRID11013263 
TBL1XEBI | SMAP55 | TBL1transducin (beta)-like 1X-linkedN-CoR interacts with TBL1.BIND12628926 
Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Reconstituted Complex
BioGRID10809664 |10944117 
|11931768 |12628926 
TBL1XR1C21 | DC42 | FLJ12894 | IRA1 | TBLR1transducin (beta)-like 1 X-linked receptor 1N-CoR interacts with TBLR1.BIND12628926 
-HPRD,BioGRID11931768 |12628926 
TRIM28FLJ29029 | KAP1 | RNF96 | TF1B | TIF1Btripartite motif-containing 28Co-purificationBioGRID11013263 
TRIM33FLJ32925 | PTC7 | RFG7 | TF1G | TIF1G | TIF1GAMMA | TIFGAMMAtripartite motif-containing 33Affinity Capture-MSBioGRID14527417 
TXNRD2SELZ | TR | TR-BETA | TR3 | TRXR2thioredoxin reductase 2Reconstituted ComplexBioGRID11463857 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptorReconstituted ComplexBioGRID12460926 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD,BioGRID9531570 
ZBTB33ZNF-kaiso | ZNF348zinc finger and BTB domain containing 33-HPRD,BioGRID14527417 
ZMYND11BRAM1 | BS69 | MGC111056 | RP11-486H9.1zinc finger, MYND domain containing 11-HPRD,BioGRID10734313 
 


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