Gene Page: ESPL1

Summary
GeneID  9700
Symbol  ESPL1
Synonyms  ESP1|FLJ46492|KIAA0165|SEPARASE|SEPARIN
Description  extra spindle pole bodies homolog 1 (S. cerevisiae)
See related  HGNC:16856|MIM:604143|Ensembl:ENSG00000135476|HPRD:06825|
Locus tag  -
Gene type  protein-coding
Map location  12q
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PRKACA0.800.79
SLC25A270.770.75
DDX240.770.73
KIAA0319L0.760.74
SRPR0.760.77
DYNLL20.760.77
ENO20.750.74
MAGEE10.750.75
NFE2L10.750.75
GPI0.750.74
Top 10 negatively co-expressed genes
AF347015.21-0.53-0.43
C16orf74-0.49-0.48
IL32-0.48-0.43
GNG11-0.48-0.44
AF347015.18-0.46-0.35
C1orf54-0.46-0.45
CLEC3B-0.45-0.48
C1orf61-0.45-0.47
PLA2G5-0.45-0.36
AF347015.31-0.45-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12194817 |12672959 
GO:0008234cysteine-type peptidase activityNAS12672959 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045143homologous chromosome segregationIEASynap (GO term level: 10)-
GO:0000070mitotic sister chromatid segregationIMP12672959 
GO:0000212meiotic spindle organizationIEA-
GO:0000910cytokinesisNAS11509732 
GO:0006508proteolysisIEA-
GO:0006915apoptosisTAS11875078 
GO:0007059chromosome segregationIEA-
GO:0040001establishment of mitotic spindle localizationNAS12672959 
GO:0045875negative regulation of sister chromatid cohesionNAS12194817 
GO:0045842positive regulation of mitotic metaphase/anaphase transitionNAS12672959 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA12672959 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCNB1CCNBcyclin B1Separase interacts with Cyclin B1.BIND15989971 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to MSeparase interacts with Cdk1.BIND15989971 
CKS2CKSHS2CDC28 protein kinase regulatory subunit 2Separase interacts with Cks2.BIND15989971 
PTTG1EAP1 | HPTTG | MGC126883 | MGC138276 | PTTG | TUTR1pituitary tumor-transforming 1Separase interacts with Securin.BIND15989971 
ESPL1 (separase) interacts with PTTG1 (securin).BIND15880121 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN 5325All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_DN 12267All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN 8748All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
AMUNDSON_GAMMA_RADIATION_RESPONSE 4025All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
GRADE_COLON_VS_RECTAL_CANCER_DN 5636All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_DN 2917All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP 8750All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2 182102All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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