Gene Page: RAPGEF5

Summary
GeneID  9771
Symbol  RAPGEF5
Synonyms  GFR|KIAA0277|MR-GEF|REPAC
Description  Rap guanine nucleotide exchange factor (GEF) 5
See related  HGNC:16862|MIM:609527|HPRD:15208|
Locus tag  tcag7.1034
Gene type  protein-coding
Map location  7p15.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BTBD90.880.89
TRAPPC100.860.86
ABR0.860.87
ATXN1L0.860.86
SYT110.860.86
RGL10.860.86
HIPK10.850.87
RAPGEF20.850.86
LRP110.850.84
MTMR120.850.86
Top 10 negatively co-expressed genes
AF347015.21-0.57-0.48
C1orf54-0.55-0.54
GNG11-0.54-0.49
IL32-0.53-0.51
SYCP3-0.53-0.53
AL050337.1-0.51-0.49
C1orf61-0.50-0.52
AC098691.2-0.50-0.48
APOC1-0.49-0.42
VAMP5-0.49-0.38
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0017034Rap guanyl-nucleotide exchange factor activityIDA10486569 
GO:0030742GTP-dependent protein bindingIPI10934204 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentNASneurite (GO term level: 5)10486569 
GO:0007264small GTPase mediated signal transductionIEA-
GO:0051056regulation of small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIDA10486569 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MRASFLJ42964 | M-RAs | R-RAS3 | RRAS3muscle RAS oncogene homologAffinity Capture-Western
Reconstituted Complex		BioGRID10934204 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyRap1A interacts with Repac.BIND15856025 
Biochemical ActivityBioGRID10777494 |10934204 
RAP2AK-REV | KREV | RAP2 | RbBP-30RAP2A, member of RAS oncogene familyBiochemical ActivityBioGRID10777494 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_DN 8453All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN 7444All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN 3119All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
BASSO_CD40_SIGNALING_DN 6844All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_DN 5235All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
JIANG_TIP30_TARGETS_UP 4628All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_UP 10759All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_4 11066All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101355435601Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-125/351379037971A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-137399740041A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-144355435601Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-182352735341A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-196377937851Ahsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-218187118771Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-2196216271Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-3781491551Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-496398339891Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-96352835341Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.