Gene Page

Gene Page: PHYHIP

Summary

GeneID

9796

Symbol

PHYHIP

Synonyms

DYRK1AP3|KIAA0273|PAHX-AP|PAHXAP1

Description

phytanoyl-CoA 2-hydroxylase interacting protein

Locus tag

Gene type

protein-coding

Map location

8p21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.03086

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.00057

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

C1orf92

0.95

0.50

C3orf25

0.95

0.59

CCDC114

0.95

0.50

WDR93

0.94

0.56

WDR63

0.93

0.43

CCDC108

0.93

0.64

RIBC1

0.93

0.59

CCDC11

0.93

0.54

CCDC135

0.93

0.53

CCDC19

0.93

0.42

Top 10 negatively co-expressed genes

CIDEA

-0.20

-0.24

NUAK1

-0.19

RGS6

-0.18

-0.24

IER5L

-0.18

ANKRD56

-0.17

-0.13

FBXW7

-0.17

-0.15

EMX1

-0.17

-0.22

KCNV1

-0.17

-0.10

LNX1

-0.17

-0.13

SLC26A4

-0.16

-0.14

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BAI1	FLJ41988	brain-specific angiogenesis inhibitor 1	-	HPRD	11245925
C14orf1	ERG28 \| NET51	chromosome 14 open reading frame 1	Two-hybrid	BioGRID	16169070
C1orf156	AsTP2 \| MGC9084 \| RP1-117P20.4	chromosome 1 open reading frame 156	Two-hybrid	BioGRID	16169070
COPS6	CSN6 \| MOV34-34KD	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	Two-hybrid	BioGRID	16169070
DYRK1A	DYRK \| DYRK1 \| HP86 \| MNB \| MNBH	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	DYRK1A interacts with PAHX-AP1.	BIND	15694837
DYRK1A	DYRK \| DYRK1 \| HP86 \| MNB \| MNBH		-	HPRD	15694837
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	Two-hybrid	BioGRID	16169070
FAM131A	C3orf40 \| FLAT715 \| MGC21688 \| PRO1378	family with sequence similarity 131, member A	Two-hybrid	BioGRID	16169070
HDAC11	FLJ22237	histone deacetylase 11	Two-hybrid	BioGRID	16169070
MAGED4B	MGC3210 \| MGC88639	melanoma antigen family D, 4B	Two-hybrid	BioGRID	16169070
MED8	ARC32 \| MGC17544 \| MGC19641	mediator complex subunit 8	Two-hybrid	BioGRID	16169070
NDRG1	CAP43 \| CMT4D \| DRG1 \| GC4 \| HMSNL \| NDR1 \| NMSL \| PROXY1 \| RIT42 \| RTP \| TARG1 \| TDD5	N-myc downstream regulated 1	Two-hybrid	BioGRID	16169070
NDUFV3	CI-9KD	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	Two-hybrid	BioGRID	16169070
PHYH	LN1 \| LNAP1 \| PAHX \| PHYH1 \| RD	phytanoyl-CoA 2-hydroxylase	-	HPRD	10686344
PNPLA2	1110001C14Rik \| ATGL \| DESNUTRIN \| DKFZp667M109 \| FP17548 \| PEDF-R \| TTS-2.2 \| TTS2	patatin-like phospholipase domain containing 2	Two-hybrid	BioGRID	16169070
PPIE	CYP-33 \| MGC111222 \| MGC3736	peptidylprolyl isomerase E (cyclophilin E)	Two-hybrid	BioGRID	16169070
PRMT5	HRMT1L5 \| IBP72 \| JBP1 \| SKB1 \| SKB1Hs	protein arginine methyltransferase 5	Two-hybrid	BioGRID	16169070
S100A13	-	S100 calcium binding protein A13	Two-hybrid	BioGRID	16169070
SMARCC2	BAF170 \| CRACC2 \| Rsc8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	Two-hybrid	BioGRID	16169070
TTR	HsT2651 \| PALB \| TBPA	transthyretin	Two-hybrid	BioGRID	16169070
WDR89	C14orf150 \| MGC9907 \| MSTP050	WD repeat domain 89	Two-hybrid	BioGRID	16169070
ZZEF1	FLJ10821 \| FLJ23789 \| FLJ45574 \| KIAA0399 \| MGC166929 \| ZZZ4	zinc finger, ZZ-type with EF-hand domain 1	Two-hybrid	BioGRID	16169070

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	446	452	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	446	452	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-140	1612	1618	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-185	82	88	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-299-5p	1611	1617	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.