| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1021 |
Name | CDK6 |
Synonym | MCPH12|PLSTIRE;cyclin-dependent kinase 6;CDK6;cyclin-dependent kinase 6 |
Definition | cell division protein kinase 6|serine/threonine-protein kinase PLSTIRE |
Position | 7q21-q22 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 4705 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | IL2 signaling events mediated by STAT5;PID Curated;200158 |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Coregulation of Androgen receptor activity;PID Curated;200038 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Disease | Height;NHGRI |
Disease | Wegener's granulomatosis;GAD |
Disease | IMMUNE;GAD |
Disease | ER positive;GAD |
Disease | Hematological and biochemical traits;NHGRI |
Disease | CANCER;GAD |
Disease | Rheumatoid arthritis;NHGRI |
Disease | rheumatoid arthritis;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | height;GAD |
|
External Links |
|
Links to Entrez Gene | 1021 |
Links to all GeneRIF Items | 1021 |
Links to iHOP | 1021 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1021 : length: 981 atggagaaggacggcctgtgccgcgctgaccagcagtacgaatgcgtggcggagatcggg gagggcgcctatgggaaggtgttcaaggcccgcgacttgaagaacggaggccgtttcgtg gcgttgaagcgcgtgcgggtgcagaccggcgaggagggcatgccgctctccaccatccgc gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt gatgtgtgcacagtgtcacgaacagacagagaaaccaaactaactttagtgtttgaacat gtcgatcaagacttgaccacttacttggataaagttccagagcctggagtgcccactgaa accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattcacaccga gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagcggacaaataaaa ctcgctgacttcggccttgcccgcatctatagtttccagatggctctaacctcagtggtc gtcacgctgtggtacagagcacccgaagtcttgctccagtccagctacgccacccccgtg gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt ggaagttcagatgttgatcaactaggaaaaatcttggacgtgattggactcccaggagaa gaagactggcctagagatgttgcccttcccaggcaggcttttcattcaaaatctgcccaa ccaattgagaagtttgtaacagatatcgatgaactaggcaaagacctacttctgaagtgt ttgacatttaacccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc caggacctggaaaggtgcaaagaaaacctggattcccacctgccgcccagccagaacacc tcggagctgaatacagcctga |
Protein Sequence |
>1021 : length: 326 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF QDLERCKENLDSHLPPSQNTSELNTA |