| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1021 |
Name | CDK6 |
Synonymous | MCPH12|PLSTIRE;cyclin-dependent kinase 6;CDK6;cyclin-dependent kinase 6 |
Definition | cell division protein kinase 6|serine/threonine-protein kinase PLSTIRE |
Position | 7q21-q22 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
cyclinD(h) + Cdk6(h) <==> cyclinD(h):Cdk6(h) (binding) | Cdk6(h) + p15INK4b(h) <==> Cdk6(h):p15INK4b(h) (binding) | Cdk6(h) + p16INK4a(h) <==> Cdk6(h):p16INK4a(h) (binding) | Cdk6(h) + p18INK4c(h) <==> Cdk6(h):p18INK4c(h) (binding) | Cdk6(h) + p19INK4d(h) <==> Cdk6(h):p19INK4d(h) (binding) | Cdk6(h) + p27Kip1(h) <==> Cdk6(h):p27Kip1(h) (binding) | Cdk6(h) + p19INK4d(m) <==> Cdk6(h):p19INK4d(m) (binding) | Cdk6(h) + p16INK4a(h) <==> Cdk6(h):p16INK4a(h) (binding) | Cdk6(h) + p15INK4b(m.s.) <==> Cdk6(h):p15INK4b(m.s.) (binding) | Cdk6(h) + p16INK4a(m.s.) <==> Cdk6(h):p16INK4a(m.s.) (binding) | Cdk6(h){pT177} --PP2Calpha1(h)--> Cdk6(h) + p (dephosphorylation) | Cdk6(h){pT177} --PP2Cbeta2(h)--> Cdk6(h) + p (dephosphorylation) | CDK6(h) --> Cdk6(h) (expression). | p75NTR(m.s.) --/ Cdk6(h) (decrease of abundance) | p15INK4b(h) + Cdk6(h) <==> p15INK4b(h):Cdk6(h) (binding) | CDK6(h) --> Cdk6(h) (expression). | hsa-miR-34a --/ CDK6(h) (increase of mRNA decay). | CDK6(h) --> CDK6(h) (expression). | hsa-miR-137 --/ CDK6(h) (increase of mRNA decay). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
13 | Phosphotyrosine. | Swiss-Prot 53.0 | 24 | Phosphotyrosine. | Swiss-Prot 53.0 | 13 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 24 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 92300648 - 92302648 | Agilent_014791 |
chr7 |
Promoter: 92300648 - 92302648 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 92300648 - 92302648 | GSE27584 |
chr7 |
Promoter: 92300648 - 92302648 | E-GEOD-20553 |
chr7 |
Promoter: 92300648 - 92302648 | Agilent_014791 |