Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1111

Name

CHEK1

Synonym

CHK1;checkpoint kinase 1;CHEK1;checkpoint kinase 1

Definition

CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1

Position

11q24.2

Gene Type

protein-coding

TSG scores

Description

TUSON ranking

4874

TUSON P-value

1

Pathways and Diseases

Pathway

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938

Pathway

cell cycle: g2/m checkpoint;PID BioCarta;100159

Pathway

Activation of ATR in response to replication stress;PID Reactome;500319

Pathway

Circadian rhythm pathway;PID Curated;200068

Pathway

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;PID Reactome;500318

Pathway

Cell Cycle Checkpoints;Reactome;REACT:1538

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

G2/M DNA damage checkpoint;PID Reactome;500952

Pathway

regulation of cell cycle progression by plk3;PID BioCarta;100068

Pathway

cdc25 and chk1 regulatory pathway in response to dna damage;PID BioCarta;100212

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

atm signaling pathway;PID BioCarta;100235

Pathway

rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046

Pathway

G2/M Checkpoints;PID Reactome;500874

Pathway

p53 pathway;PID Curated;200175

Disease

CANCER;GAD

Disease

Cancer;FunDO

Disease

Fanconi's anemia;FunDO

Disease

colorectal cancer;GAD

External Links

Links to Entrez Gene

1111

Links to all GeneRIF Items

1111

Links to iHOP

1111

Sequence Information

The sequences provided here are only the longest representative sequences, not covering all the isoforms.

Nucleotide Sequence

>1111 : length: 1431
atggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctat
ggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgta
gatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaa
atgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaa
tatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacata
ggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttat
ctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaa
agggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgt
gagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaag
agaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgca
atgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgac
tggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagct
ctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaa
aaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttca
ggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttc
tctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaa
ccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaa
gggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttactt
ggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattc
tttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttg
ggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggaga
aacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgac
ttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaaggg
aagctgattgatattgtgagcagccagaagatttggcttcctgccacatga

Protein Sequence

>1111 : length: 476
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT



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