Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1111

Name

CHEK1

Synonymous

CHK1;checkpoint kinase 1;CHEK1;checkpoint kinase 1

Definition

CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1

Position

11q24.2

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Chk1(h) + ATP --ATR(h)--> Chk1(h){p} + ADP (phosphorylation)
Cdc25A(h) + Chk1(h) <==> Cdc25A(h):Chk1(h) (binding)
Cdc25B(h) + Chk1(h) <==> Cdc25B(h):Chk1(h) (binding)
Cdc25C(h) + Chk1(h) <==> Cdc25C(h):Chk1(h) (binding)
brca1(h) + Chk1(h) <==> brca1(h):Chk1(h) (binding)
Chk1(h) + p73alpha(h) <==> Chk1(h):p73alpha(h) (binding)
Chk1(h) + p73beta(h) <==> Chk1(h):p73beta(h) (binding)
Wip1(h) + Chk1(h) <==> Wip1(h):Chk1(h) (binding)
BLM(h) + Chk1(h) <==> BLM(h):Chk1(h) (binding)
Chk1(h) + ATP --> Chk1(h){pS317} + ADP (phosphorylation)
Chk1(h) + ATP --> Chk1(h){pS345} + ADP (phosphorylation)
Chk1(h) + ATP --ATR(h)--> Chk1(h){pS345} + ADP (phosphorylation)
Chk1(h) + Claspin(h){p}n <==> Chk1(h):Claspin(h){p}n (binding)
Chk1(h) + ATP --> Chk1(h){p} + ADP (phosphorylation)
Chk1(h) --/ Cdc25A(h) (inhibition; decrease of abundance)
Cdc25C(h):Chk1(h) + ATP --> Cdc25C(h){pS216} + Chk1(h) + ADP (phosphorylation; dissociation)
Cdc25B(h):Chk1(h) + ATP --> Cdc25B(h){p} + Chk1(h) + ADP (phosphorylation; dissociation)
Cdc25A(h):Chk1(h) + ATP --> Cdc25A(h){p} + Chk1(h) + ADP (phosphorylation; dissociation)
CHEK1(h) --> Chk1(h) (expression).
Chk1(h){pS345} --Wip1(h)--> p + Chk1(h) (dephosphorylation)
Chk1(h){pS345} --> Chk1(h) + p (dephosphorylation)
HAUSP(h) --> Chk1(h) (activation)
Cdc25(h) + ATP --Chk1(h)--> Cdc25(h){p} + ADP (phosphorylation)
p53(h) + ATP --Chk1(h)--> p53(h){pS15} + ADP (phosphorylation)
p53(h) + ATP --Chk1(h)--> p53(h){pS20} + ADP (phosphorylation)
p53(h) + ATP --Chk1(h)--> p53(h){pS37} + ADP (phosphorylation)
Cdc25B3(h) + ATP --Chk1(h)--> Cdc25B3(h){p} + ADP (phosphorylation)
p73alpha(h) + ATP --Chk1(h)--> p73alpha(h){pS47} + ADP (phosphorylation)
BLM(h) + ATP --Chk1(h)--> BLM(h){pS} + ADP (phosphorylation)
Mdm4(h) + ATP --Chk1(h)--> Mdm4(h){pS367} + ADP (phosphorylation)
Cdc25C(m.s.) + ATP --Chk1(h)--> Cdc25C(m.s.){pS216} + ADP (phosphorylation)
Chk1(h) + 2 ATP --ATM(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation)
Chk1(h) + 2 ATP --ATR(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation)
Chk1(h) + 2 ATP --DNA-PK(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation)
Chk1(h) --> Cdc25A(h){ub(n)} (increase of ubiquitination)
CHEK1(h) --> Chk1(h) (expression).
Chk1(h){pS345} --Wip1(m.s.)--> Chk1(h) + p (dephosphorylation)
Aurora-B(h) + ATP --Chk1(h)--> Aurora-B(h){p} + ADP (phosphorylation)
Cdc25C(h) + ATP --Chk1(h)--> Cdc25C(h){p} + ADP (phosphorylation)
Cdc25C-isoform1(h) + ATP --Chk1(h)--> Cdc25C-isoform1(h){pS216} + ADP (phosphorylation)
Cdc25A(h) + ATP --Chk1(h)--> Cdc25A(h){pS76} + ADP (phosphorylation)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

280Phosphoserine (by PKB/AKT1) (Bysimilarity).Swiss-Prot 53.0
296Phosphoserine.Swiss-Prot 53.0
317Phosphoserine (by ATM and ATR).Swiss-Prot 53.0
345Phosphoserine (by ATM and ATR).Swiss-Prot 53.0
317Phosphoserine (ATM;ATR)11252893;11390642Phospho.ELM 6.0
345Phosphoserine (ATM;ATR)11390642;10859164;15533933;15674326Phospho.ELM 6.0
296Phosphoserine15975956Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr11

Promoter: 125000047 - 125002047Agilent_014791

chr11

Promoter: 125000047 - 125002047GSE27584

chr11

Promoter: 125000047 - 125002047Agilent_014791_44K

chr11

Promoter: 125000047 - 125002047Agilent_014791


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