| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 11184 |
Name | MAP4K1 |
Synonym | HPK1;mitogen-activated protein kinase kinase kinase kinase 1;MAP4K1;mitogen-activated protein kinase kinase kinase kinase 1 |
Definition | MAPK/ERK kinase kinase kinase 1|MEK kinase kinase 1|MEKKK 1|hematopoietic progenitor kinase 1 |
Position | 19q13.1-q13.4 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 10300 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Disease | Colon cancer;FunDO |
|
External Links |
|
Links to Entrez Gene | 11184 |
Links to all GeneRIF Items | 11184 |
Links to iHOP | 11184 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>11184 : length: 2466 atggacgtcgtggaccctgacattttcaatagagacccccgggaccactatgacctgcta cagcggctgggtggcggcacgtatggggaagtctttaaggctcgagacaaggtgtcaggg gacctggtggcactgaagatggtgaagatggagcctgatgatgatgtctccacccttcag aaggaaatcctcatattgaaaacttgccggcacgccaacatcgtggcctaccatgggagt tatctctggttgcagaaactctggatctgcatggaattctgtggggctggttctctccag gacatctaccaagtgacaggctccctgtcagagctccagattagctatgtctgccgggaa gtgctccagggactggcctatttgcactcacagaagaagatacacagggacatcaaggga gctaacatcctcatcaatgatgctggggaggtcagattggctgactttggcatctcggcc cagattggggctacactggccagacgcctctctttcattgggacaccctactggatggct ccggaagtggcagctgtggccctgaagggaggatacaatgagctgtgtgacatctggtcc ctgggcatcacggccatcgaactggccgagctacagccaccgctctttgatgtgcaccct ctcagagttctcttcctcatgaccaagagtggctaccagcctccccgactgaaggaaaaa ggcaaatggtcggctgccttccacaacttcatcaaagtcactctgactaagagtcccaag aaacgacccagcgccaccaagatgctcagtcatcaactggtatcccagcctgggctgaat cgaggcctgatcctggatcttcttgacaaactgaagaatcccgggaaaggaccctccatt ggggacattgaggatgaggagcccgagctaccccctgctatccctcggcggatcagatcc acccaccgctccagctctctggggatcccagatgcagactgctgtcggcggcacatggag ttcaggaagctccgaggaatggagaccagacccccagccaacaccgctcgcctacagcct cctcgagacctcaggagcagcagccccaggaagcaactgtcagagtcgtctgacgatgac tatgacgacgtggacatccccacccctgcagaggacacacctcctccacttccccccaag cccaagttccgttctccatcagacgagggtcctgggagcatgggggatgatgggcagctg agcccgggggtgctggtccggtgtgccagtgggcccccaccaaacagcccccgtcctggg cctcccccatccaccagcagcccccacctcaccgcccattcagaaccctcactctggaac ccaccctcccgggagcttgacaagcccccacttctgccccccaagaaggaaaagatgaag agaaagggatgtgcccttctcgtaaagttgttcaatggctgccccctccggatccacagc acggccgcctggacacatccctccaccaaggaccagcacctgctcctgggggcagaggaa ggcatcttcatcctgaaccggaatgaccaggaggccacgctggaaatgctctttcctagc cggactacgtgggtgtactccatcaacaacgttctcatgtctctctcaggaaagaccccc cacctgtattctcatagcatccttggcctgctggaacggaaagagaccagagcaggaaac cccatcgctcacattagcccccaccgcctactggcaaggaagaacatggtttccaccaag atccaggacaccaaaggctgccgggcgtgctgtgtggcggagggtgcgagctctgggggc ccgttcctgtgcggtgcattggagacgtccgttgtcctgcttcagtggtaccagcccatg aacaaattcctgcttgtccggcaggtgctgttcccactgccgacgcctctgtccgtgttc gcgctgctgaccgggccaggctctgagctgcccgctgtgtgcatcggcgtgagccccggg cggccggggaagtcggtgctcttccacacggtgcgctttggcgcgctctcttgctggctg ggcgagatgagcaccgagcacaggggacccgtgcaggtgacccaggtagaggaagatatg gtgatggtgttgatggatggctctgtgaagctggtgaccccggaggggtccccagtccgg ggacttcgcacacctgagatccccatgaccgaagcggtggaggccgtggctatggttgga ggtcagcttcaggccttctggaagcatggagtgcaggtgtgggctctaggctcggatcag ctgctacaggagctgagagaccctaccctcactttccgtctgcttggctcccccaggcct gtagtggtggagacacgcccagtggatgatcctactgctcccagcaacctctacatccag gaatga |
Protein Sequence |
>11184 : length: 821 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ LLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYIQE |