Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	11184
Name	MAP4K1
Synonymous	HPK1;mitogen-activated protein kinase kinase kinase kinase 1;MAP4K1;mitogen-activated protein kinase kinase kinase kinase 1
Definition	MAPK/ERK kinase kinase kinase 1\|MEK kinase kinase 1\|MEKKK 1\|hematopoietic progenitor kinase 1
Position	19q13.1-q13.4
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]
	There is no record for MAP4K1

Regulation From TransFac database
Transcription Factors [Top]
HPK1(h) + TAK1(m) <==> HPK1(h):TAK1(m) (binding)
HIP-55(h) + HPK1(h) <==> HIP-55(h):HPK1(h) (binding)
HPK1(h) + ATP --> HPK1(h){pY} + ADP (phosphorylation)
HPK1(h) + ATP --> HPK1(h){p} + ADP (phosphorylation)
MAP4K1(h) --> HPK1(h) (expression).
MAP4K1(h) --> HPK1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
366	Phosphoserine.		Swiss-Prot 53.0
368	Phosphoserine.		Swiss-Prot 53.0
374	Phosphoserine.		Swiss-Prot 53.0
376	Phosphoserine.		Swiss-Prot 53.0
381	Phosphotyrosine.		Swiss-Prot 53.0
407	Phosphoserine.		Swiss-Prot 53.0
413	Phosphoserine.		Swiss-Prot 53.0
421	Phosphoserine.		Swiss-Prot 53.0
586	Phosphoserine.		Swiss-Prot 53.0
381	Phosphotyrosine (Syk)	11514608;11487585	Phospho.ELM 6.0
366	Phosphoserine	15302935	Phospho.ELM 6.0
368	Phosphoserine	15302935	Phospho.ELM 6.0
171	Phosphoserine	15743830	Phospho.ELM 6.0
165	Phosphothreonine	15743830	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr19	Promoter: 43799983 - 43801983	GSE27584
chr19	Promoter: 43799983 - 43801983	GSE27584
chr19	Promoter: 43799983 - 43801983	Agilent_014791_44K

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