| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 142 |
Name | PARP1 |
Synonym | ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1;poly (ADP-ribose) polymerase 1;PARP1;poly (ADP-ribose) polymerase 1 |
Definition | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)|ADP-ribosyltransferase NAD(+)|ADP-ribosyltransferase diphtheria toxin-like 1|NAD(+) ADP-ribosyltransferase 1|poly (ADP-ribose) polymerase family, member 1|poly [ADP-ribose] polymerase 1|poly(ADP- |
Position | 1q41-q42 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 12362 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | opposing roles of aif in apoptosis and cell survival;PID BioCarta;100249 |
Pathway | Base excision repair;KEGG PATHWAY;hsa03410 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | induction of apoptosis through dr3 and dr4/5 death receptors;PID BioCarta;100189 |
Pathway | caspase cascade in apoptosis;PID BioCarta;100218 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Disease | CANCER;GAD |
Disease | Ischemia;FunDO |
Disease | Alzheimer's disease;GAD |
Disease | Melanoma;FunDO |
Disease | Kaposi sarcoma;FunDO |
Disease | glomerulonephritis;GAD |
Disease | arthritis;GAD |
Disease | Liver cancer;FunDO |
Disease | Xeroderma pigmentosum;OMIM |
Disease | Werner syndrome;FunDO |
Disease | Parkinson disease;FunDO |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | Fanconi's anemia;FunDO |
Disease | lung cancer;GAD |
Disease | IMMUNE;GAD |
Disease | Parkinson's disease;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Leukemia;FunDO |
Disease | Asthma;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | lupus erythematosus;GAD |
Disease | rheumatoid arthritis;GAD |
Disease | Neoplasms;GAD |
Disease | predisposition to cancer;GAD |
Disease | METABOLIC;GAD |
Disease | Common cold;FunDO |
Disease | Ewings sarcoma;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Uterine fibroids;FunDO |
Disease | diabetes, type 2;GAD |
Disease | Chronic obstructive airway disease;FunDO |
Disease | Breast cancer;FunDO |
Disease | Renal tubular acidosis;FunDO |
Disease | Heart failure;FunDO |
Disease | Celiac disease;FunDO |
Disease | Pituitary tumor;FunDO |
Disease | Kidney tubular necrosis, acute;FunDO |
Disease | Lupus;GAD |
Disease | RENAL;GAD |
|
External Links |
|
Links to Entrez Gene | 142 |
Links to all GeneRIF Items | 142 |
Links to iHOP | 142 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>142 : length: 3045 atggcggagtcttcggataagctctatcgagtcgagtacgccaagagcgggcgcgcctct tgcaagaaatgcagcgagagcatccccaaggactcgctccggatggccatcatggtgcag tcgcccatgtttgatggaaaagtcccacactggtaccacttctcctgcttctggaaggtg ggccactccatccggcaccctgacgttgaggtggatgggttctctgagcttcggtgggat gaccagcagaaagtcaagaagacagcggaagctggaggagtgacaggcaaaggccaggat ggaattggtagcaaggcagagaagactctgggtgactttgcagcagagtatgccaagtcc aacagaagtacgtgcaaggggtgtatggagaagatagaaaagggccaggtgcgcctgtcc aagaagatggtggacccggagaagccacagctaggcatgattgaccgctggtaccatcca ggctgctttgtcaagaacagggaggagctgggtttccggcccgagtacagtgcgagtcag ctcaagggcttcagcctccttgctacagaggataaagaagccctgaagaagcagctccca ggagtcaagagtgaaggaaagagaaaaggcgatgaggtggatggagtggatgaagtggcg aagaagaaatctaaaaaagaaaaagacaaggatagtaagcttgaaaaagccctaaaggct cagaacgacctgatctggaacatcaaggacgagctaaagaaagtgtgttcaactaatgac ctgaaggagctactcatcttcaacaagcagcaagtgccttctggggagtcggcgatcttg gaccgagtagctgatggcatggtgttcggtgccctccttccctgcgaggaatgctcgggt cagctggtcttcaagagcgatgcctattactgcactggggacgtcactgcctggaccaag tgtatggtcaagacacagacacccaaccggaaggagtgggtaaccccaaaggaattccga gaaatctcttacctcaagaaattgaaggttaaaaaacaggaccgtatattccccccagaa accagcgcctccgtggcggccacgcctccgccctccacagcctcggctcctgctgctgtg aactcctctgcttcagcagataagccattatccaacatgaagatcctgactctcgggaag ctgtcccggaacaaggatgaagtgaaggccatgattgagaaactcggggggaagttgacg gggacggccaacaaggcttccctgtgcatcagcaccaaaaaggaggtggaaaagatgaat aagaagatggaggaagtaaaggaagccaacatccgagttgtgtctgaggacttcctccag gacgtctccgcctccaccaagagccttcaggagttgttcttagcgcacatcttgtcccct tggggggcagaggtgaaggcagagcctgttgaagttgtggccccaagagggaagtcaggg gctgcgctctccaaaaaaagcaagggccaggtcaaggaggaaggtatcaacaaatctgaa aagagaatgaaattaactcttaaaggaggagcagctgtggatcctgattctggactggaa cactctgcgcatgtcctggagaaaggtgggaaggtcttcagtgccacccttggcctggtg gacatcgttaaaggaaccaactcctactacaagctgcagcttctggaggacgacaaggaa aacaggtattggatattcaggtcctggggccgtgtgggtacggtgatcggtagcaacaaa ctggaacagatgccgtccaaggaggatgccattgagcacttcatgaaattatatgaagaa aaaaccgggaacgcttggcactccaaaaatttcacgaagtatcccaaaaagttctacccc ctggagattgactatggccaggatgaagaggcagtgaagaagctgacagtaaatcctggc accaagtccaagctccccaagccagttcaggacctcatcaagatgatctttgatgtggaa agtatgaagaaagccatggtggagtatgagatcgaccttcagaagatgcccttggggaag ctgagcaaaaggcagatccaggccgcatactccatcctcagtgaggtccagcaggcggtg tctcagggcagcagcgactctcagatcctggatctctcaaatcgcttttacaccctgatc ccccacgactttgggatgaagaagcctccgctcctgaacaatgcagacagtgtgcaggcc aaggtggaaatgcttgacaacctgctggacatcgaggtggcctacagtctgctcagggga gggtctgatgatagcagcaaggatcccatcgatgtcaactatgagaagctcaaaactgac attaaggtggttgacagagattctgaagaagccgagatcatcaggaagtatgttaagaac actcatgcaaccacacacaatgcgtatgacttggaagtcatcgatatctttaagatagag cgtgaaggcgaatgccagcgttacaagccctttaagcagcttcataaccgaagattgctg tggcacgggtccaggaccaccaactttgctgggatcctgtcccagggtcttcggatagcc ccgcctgaagcgcccgtgacaggctacatgtttggtaaagggatctatttcgctgacatg gtctccaagagtgccaactactgccatacgtctcagggagacccaataggcttaatcctg ttgggagaagttgcccttggaaacatgtatgaactgaagcacgcttcacatatcagcaag ttacccaagggcaagcacagtgtcaaaggtttgggcaaaactacccctgatccttcagct aacattagtctggatggtgtagacgttcctcttgggaccgggatttcatctggtgtgaat gacacctctctactatataacgagtacattgtctatgatattgctcaggtaaatctgaag tatctgctgaaactgaaattcaattttaagacctccctgtggtaa |
Protein Sequence |
>142 : length: 1014 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW |