| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1540 |
Name | CYLD |
Synonym | BRSS|CDMT|CYLD1|CYLDI|EAC|MFT|MFT1|SBS|TEM|USPL2;cylindromatosis (turban tumor syndrome);CYLD;cylindromatosis (turban tumor syndrome) |
Definition | deubiquitinating enzyme CYLD|probable ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin specific peptidase like 2|ubiquitin thioesterase CYLD|ubiquitin thiolesterase CYLD|ubiquitin-specific-processing protease |
Position | 16q12.1 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 105 |
TUSON P-value | 1.54E-05 |
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Pathways and Diseases |
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Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Disease | Multiple familial trichoepithelioma and familial cylindromatosis;GAD |
Disease | Infectious lung disease;FunDO |
Disease | Spiegler-Brooke syndrome;OMIM |
Disease | Multiple myeloma;FunDO |
Disease | CANCER;GAD |
Disease | Cylindromatosis, familial;OMIM |
Disease | Trichoepithelioma, multiple familial, 1;OMIM |
Disease | Hodgkin's disease;FunDO |
Disease | Liver cancer;FunDO |
Disease | Adenoid cystic cancer;FunDO |
Disease | Brooke-Spiegler syndrome;OMIM |
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External Links |
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Links to Entrez Gene | 1540 |
Links to all GeneRIF Items | 1540 |
Links to iHOP | 1540 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1540 : length: 2862 atgagttcaggcttatggagccaagaaaaagtcacttcaccctactgggaagagcggatt ttttacttgcttcttcaagaatgcagcgttacagacaaacaaacacaaaagctccttaaa gtaccgaagggaagtataggacagtatattcaagatcgttctgtggggcattcaaggatt ccttctgcaaaaggcaagaaaaatcagattggattaaaaattctagagcaacctcatgca gttctctttgttgatgaaaaggatgttgtagagataaatgaaaagttcacagagttactt ttggcaattaccaattgtgaggagaggttcagcctgtttaaaaacagaaacagactaagt aaaggcctccaaatagacgtgggctgtcctgtgaaagtacagctgagatctggggaagaa aaatttcctggagttgtacgcttcagaggacccctgttagcagagaggacagtctccgga atattctttggagttgaattgctggaagaaggtcgtggtcaaggtttcactgacggggtg taccaagggaaacagctttttcagtgtgatgaagattgtggcgtgtttgttgcattggac aagctagaactcatagaagatgatgacactgcattggaaagtgattacgcaggtcctggg gacacaatgcaggtcgaacttcctcctttggaaataaactccagagtttctttgaaggtt ggagaaacaatagaatctggaacagttatattctgtgatgttttgccaggaaaagaaagc ttaggatattttgttggtgtggacatggataaccctattggcaactgggatggaagattt gatggagtgcagctttgtagttttgcgtgtgttgaaagtacaattctattgcacatcaat gatatcatcccagagagtgtgacgcaggaaaggaggcctcccaaacttgcctttatgtca agaggtgttggggacaaaggttcatccagtcataataaaccaaaggctacaggatctacc tcagaccctggaaatagaaacagatctgaattattttataccttaaatgggtcttctgtt gactcacaaccacaatccaaatcaaaaaatacatggtacattgatgaagttgcagaagac cctgcaaaatctcttacagagatatctacagactttgaccgttcttcaccaccactccag cctcctcctgtgaactcactgaccaccgagaacagattccactctttaccattcagtctc accaagatgcccaataccaatggaagtattggccacagtccactttctctgtcagcccag tctgtaatggaagagctaaacactgcacccgtccaagagagtccacccttggccatgcct cctgggaactcacatggtctagaagtgggctcattggctgaagttaaggagaaccctcct ttctatggggtaatccgttggatcggtcagccaccaggactgaatgaagtgctcgctgga ctggaactggaagatgagtgtgcaggctgtacggatggaaccttcagaggcactcggtat ttcacctgtgccctgaagaaggcgctgtttgtgaaactgaagagctgcaggcctgactct aggtttgcatcattgcagccggtttccaatcagattgagcgctgtaactctttagcattt ggaggctacttaagtgaagtagtagaagaaaatactccaccaaaaatggaaaaagaaggc ttggagataatgattgggaagaagaaaggcatccagggtcattacaattcttgttactta gactcaaccttattctgcttatttgcttttagttctgttctggacactgtgttacttaga cccaaagaaaagaacgatgtagaatattatagtgaaacccaagagctactgaggacagaa attgttaatcctctgagaatatatggatatgtgtgtgccacaaaaattatgaaactgagg aaaatacttgaaaaggtggaggctgcatcaggatttacctctgaagaaaaagatcctgag gaattcttgaatattctgtttcatcatattttaagggtagaacctttgctaaaaataaga tcagcaggtcaaaaggtacaagattgttacttctatcaaatttttatggaaaaaaatgag aaagttggcgttcccacaattcagcagttgttagaatggtcttttatcaacagtaacctg aaatttgcagaggcaccatcatgtctgattattcagatgcctcgatttggaaaagacttt aaactatttaaaaaaatttttccttctctggaattaaatataacagatttacttgaagac actcccagacagtgccggatatgtggagggcttgcaatgtatgagtgtagagaatgctac gacgatccggacatctcagctggaaaaatcaagcagttttgtaaaacctgcaacactcaa gtccaccttcatccgaagaggctgaatcataaatataacccagtgtcacttcccaaagac ttacccgactgggactggagacacggctgcatcccttgccagaatatggagttatttgct gttctctgcatagaaacaagccactatgttgcttttgtgaagtatgggaaggacgattct gcctggctcttctttgacagcatggccgatcgggatggtggtcagaatggcttcaacatt cctcaagtcaccccatgcccagaagtaggagagtacttgaagatgtctctggaagacctg cattccttggactccaggagaatccaaggctgtgcacgaagactgctttgtgatgcatat atgtgcatgtaccagagtccaacaatgagtttgtacaaataa |
Protein Sequence |
>1540 : length: 953 MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRI PSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERFSLFKNRNRLS KGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKV GETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFACVESTILLHIN DIIPESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNGSSV DSQPQSKSKNTWYIDEVAEDPAKSLTEISTDFDRSSPPLQPPPVNSLTTENRFHSLPFSL TKMPNTNGSIGHSPLSLSAQSVMEELNTAPVQESPPLAMPPGNSHGLEVGSLAEVKENPP FYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDS RFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYL DSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLR KILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNE KVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLED TPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKD LPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNI PQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK |