Entrez Gene

Basic Information
Gene ID	1540
Name	CYLD
Synonymous	BRSS\|CDMT\|CYLD1\|CYLDI\|EAC\|MFT\|MFT1\|SBS\|TEM\|USPL2;cylindromatosis (turban tumor syndrome);CYLD;cylindromatosis (turban tumor syndrome)
Definition	deubiquitinating enzyme CYLD\|probable ubiquitin carboxyl-terminal hydrolase CYLD\|ubiquitin carboxyl-terminal hydrolase CYLD\|ubiquitin specific peptidase like 2\|ubiquitin thioesterase CYLD\|ubiquitin thiolesterase CYLD\|ubiquitin-specific-processing protease
Position	16q12.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
IKK-gamma(h) + EAC(h) <==> IKK-gamma(h):EAC(h) (binding)
EAC(h) + TRAF2(h) <==> EAC(h):TRAF2(h) (binding)
EAC(h) + NTP --IKK-gamma(h)--> EAC(h){p} + NDP (phosphorylation)
EAC(h) --> IkappaB-alpha(h){p} (decrease of phosphorylation)
EAC(h) --> MKK3(h){p} (decrease of phosphorylation)
EAC(h) --> MKK6(h){p} (decrease of phosphorylation)
EAC(h) --> p38(h){p} (decrease of phosphorylation)
CYLD(h) --> EAC(h) (expression).
(ubiquitin(v.s.))4 --EAC(h)--> 4 ubiquitin(v.s.) (processing)
TRAF6(m){ub{K63}(n)} --EAC(h)--> TRAF6(m) + ubiquitin(v.s.) (deubiquitination)
TRAF2(h){ub{K63}(n)} --EAC(h)--> TRAF2(h) + n ubiquitin(v.s.) (deubiquitination)
TRAF2(v.s.){ub{K63}(n)} --EAC(h)--> TRAF2(v.s.) + n ubiquitin(h) (deubiquitination)
TRAF6(v.s.){ub{K63}(n)} --EAC(h)--> TRAF6(v.s.) + n ubiquitin(h) (deubiquitination)
IKK-gamma(h){ub{K63}(n)} --EAC(h)--> IKK-gamma(h) + n ubiquitin(h) (deubiquitination)
IKK-gamma(m.s.){ub{K63}(n)} --EAC(h)--> IKK-gamma(m.s.) + n ubiquitin(m.s.) (deubiquitination)
CYLD(h) --> EAC-isoform2(h) (expression).
CYLD(h) --> EAC-isoform1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
399	Phosphoserine.		Swiss-Prot 53.0