Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1540

Name

CYLD

Synonymous

BRSS|CDMT|CYLD1|CYLDI|EAC|MFT|MFT1|SBS|TEM|USPL2;cylindromatosis (turban tumor syndrome);CYLD;cylindromatosis (turban tumor syndrome)

Definition

deubiquitinating enzyme CYLD|probable ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin specific peptidase like 2|ubiquitin thioesterase CYLD|ubiquitin thiolesterase CYLD|ubiquitin-specific-processing protease

Position

16q12.1

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

IKK-gamma(h) + EAC(h) <==> IKK-gamma(h):EAC(h) (binding)
EAC(h) + TRAF2(h) <==> EAC(h):TRAF2(h) (binding)
EAC(h) + NTP --IKK-gamma(h)--> EAC(h){p} + NDP (phosphorylation)
EAC(h) --> IkappaB-alpha(h){p} (decrease of phosphorylation)
EAC(h) --> MKK3(h){p} (decrease of phosphorylation)
EAC(h) --> MKK6(h){p} (decrease of phosphorylation)
EAC(h) --> p38(h){p} (decrease of phosphorylation)
CYLD(h) --> EAC(h) (expression).
(ubiquitin(v.s.))4 --EAC(h)--> 4 ubiquitin(v.s.) (processing)
TRAF6(m){ub{K63}(n)} --EAC(h)--> TRAF6(m) + ubiquitin(v.s.) (deubiquitination)
TRAF2(h){ub{K63}(n)} --EAC(h)--> TRAF2(h) + n ubiquitin(v.s.) (deubiquitination)
TRAF2(v.s.){ub{K63}(n)} --EAC(h)--> TRAF2(v.s.) + n ubiquitin(h) (deubiquitination)
TRAF6(v.s.){ub{K63}(n)} --EAC(h)--> TRAF6(v.s.) + n ubiquitin(h) (deubiquitination)
IKK-gamma(h){ub{K63}(n)} --EAC(h)--> IKK-gamma(h) + n ubiquitin(h) (deubiquitination)
IKK-gamma(m.s.){ub{K63}(n)} --EAC(h)--> IKK-gamma(m.s.) + n ubiquitin(m.s.) (deubiquitination)
CYLD(h) --> EAC-isoform2(h) (expression).
CYLD(h) --> EAC-isoform1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

399Phosphoserine.Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr16

Promoter: 49331962 - 49333962Agilent_014791

chr16

Promoter: 49331962 - 49333962GSE27584

chr16

Promoter: 49332030 - 49334030GSE27584

chr16

Promoter: 49331962 - 49333962GSE27584

chr16

Promoter: 49331962 - 49333962Agilent_014791_44K

chr16

Promoter: 49332030 - 49334030Agilent_014791_44K


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