| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1643 |
Name | DDB2 |
Synonym | DDBB|UV-DDB2;damage-specific DNA binding protein 2, 48kDa;DDB2;damage-specific DNA binding protein 2, 48kDa |
Definition | DDB p48 subunit|DNA damage-binding protein 2|UV-DDB 2|UV-damaged DNA-binding protein 2|damage-specific DNA-binding protein 2|xeroderma pigmentosum group E protein |
Position | 11p12-p11 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 5784 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Formation of incision complex in GG-NER;PID Reactome;500060 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Nucleotide excision repair;KEGG PATHWAY;hsa03420 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Dual incision reaction in GG-NER;PID Reactome;500061 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Global Genomic NER (GG-NER);PID Reactome;500058 |
Disease | Inherited disorders of DNA repair systems;KEGG DISEASE |
Disease | Breast cancer;FunDO |
Disease | Disorders of nucleotide excision repair;KEGG DISEASE;H00403 |
Disease | Xeroderma pigmentosum, group E, DDB-negative subtype;OMIM |
Disease | Genetic disorders;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 1643 |
Links to all GeneRIF Items | 1643 |
Links to iHOP | 1643 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1643 : length: 1284 atggctcccaagaaacgcccagaaacccagaagacctccgagattgtattacgccccagg aacaagaggagcaggagtcccctggagctggagcccgaggccaagaagctctgtgcgaag ggctccggtcctagcagaagatgtgactcagactgcctctgggtggggctggctggccca cagatcctgccaccatgccgcagcatcgtcaggaccctccaccagcataagctgggcaga gcttcctggccatctgtccagcaggggctccagcagtcctttttgcacactctggattct taccggatattacaaaaggctgccccctttgacaggagggctacatccttggcgtggcac ccaactcaccccagcaccgtggctgtgggttccaaagggggagatatcatgctctggaat tttggcatcaaggacaaacccaccttcatcaaagggattggagctggagggagcatcact gggctgaagtttaaccctctcaataccaaccagttttacgcctcctcaatggagggaaca actaggctgcaagactttaaaggcaacattctacgagtttttgccagctcagacaccatc aacatctggttttgtagcctggatgtgtctgctagtagccgaatggtggtcacaggagac aacgtggggaacgtgatcctgctgaacatggacggcaaagagctttggaatctcagaatg cacaaaaagaaagtgacgcatgtggccctgaacccatgctgtgattggttcctggccaca gcctccgtagatcaaacagtgaaaatttgggacctgcgccaggttagagggaaagccagc ttcctctactcgctgccgcacaggcatcctgtcaacgcagcttgtttcagtcccgatgga gcccggctcctgaccacggaccagaagagcgagatccgagtttactctgcttcccagtgg gactgccccctgggcctgatcccgcaccctcaccgtcacttccagcacctcacacccatc aaggcagcctggcatcctcgctacaacctcattgttgtgggccgatacccagatcctaat ttcaaaagttgtaccccttatgaattgaggacgatcgacgtgttcgatggaaactcaggg aagatgatgtgtcagctctatgacccagaatcttctggcatcagttcgcttaatgaattc aatcccatgggggacacgctggcctctgcaatgggttaccacattctcatctggagccag gaggaagccaggacacggaagtga |
Protein Sequence |
>1643 : length: 427 MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH PTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ EEARTRK |