| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1832 |
Name | DSP |
Synonym | DCWHKTA|DP|DPI|DPII;desmoplakin;DSP;desmoplakin |
Definition | 250/210 kDa paraneoplastic pemphigus antigen|desmoplakin I|desmoplakin II |
Position | 6p24 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6198 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Apoptotic cleavage of cell adhesion proteins;PID Reactome;500272 |
Disease | Palmoplantar keratosis;FunDO |
Disease | Dilated cardiomyopathy with woolly hair and keratoderma;OMIM |
Disease | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG DISEASE;H00293 |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Skin fragility-woolly hair syndrome;OMIM |
Disease | Keratosis palmoplantaris striata II;OMIM |
Disease | Lung cancer;FunDO |
Disease | Arrhythmogenic right ventricular dysplasia 8;OMIM |
Disease | Cardiac diseases;KEGG DISEASE |
Disease | Epidermolysis bullosa, lethal acantholytic;OMIM |
|
External Links |
|
Links to Entrez Gene | 1832 |
Links to all GeneRIF Items | 1832 |
Links to iHOP | 1832 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1832 : length: 6819 atgagctgcaacggaggctcccacccgcggatcaacactctgggccgcatgatccgcgcc gagtctggcccggacctgcgctacgaggtgaccagcggcggcgggggcaccagcaggatg tactattctcggcgcggcgtgatcaccgaccagaactcggacggctactgtcaaaccggc acgatgtccaggcaccagaaccagaacaccatccaggagctgctgcagaactgctccgac tgcttgatgcgagcagagctcatcgtgcagcctgaattgaagtatggagatggaatacaa ctgactcggagtcgagaattggatgagtgttttgcccaggccaatgaccaaatggaaatc ctcgacagcttgatcagagagatgcggcagatgggccagccctgtgatgcttaccagaaa aggcttcttcagctccaagagcaaatgcgagccctttataaagccatcagtgtccctcga gtccgcagggccagctccaagggtggtggaggctacacttgtcagagtggctctggctgg gatgagttcaccaaacatgtcaccagtgaatgtttggggtggatgaggcagcaaagggcg gagatggacatggtggcctggggtgtggacctggcctcagtggagcagcacattaacagc caccggggcatccacaactccatcggcgactatcgctggcagctggacaaaatcaaagcc gacctgcgcgagaaatctgcgatctaccagttggaggaggagtatgaaaacctgctgaaa gcgtcctttgagaggatggatcacctgcgacagctgcagaacatcattcaggccacgtcc agggagatcatgtggatcaatgactgcgaggaggaggagctgctgtacgactggagcgac aagaacaccaacatcgctcagaaacaggaggccttctccatacgcatgagtcaactggaa gttaaagaaaaagagctcaataagctgaaacaagaaagtgaccaacttgtcctcaatcag catccagcttcagacaaaattgaggcctatatggacactctgcagacgcagtggagttgg attcttcagatcaccaagtgcattgatgttcatctgaaagaaaatgctgcctactttcag ttttttgaagaggcgcagtctactgaagcatacctgaaggggctccaggactccatcagg aagaagtacccctgcgacaagaacatgcccctgcagcacctgctggaacagatcaaggag ctggagaaagaacgagagaaaatccttgaatacaagcgtcaggtgcagaacttggtaaac aagtctaagaagattgtacagctgaagcctcgtaacccagactacagaagcaataaaccc attattctcagagctctctgtgactacaaacaagatcagaaaatcgtgcataagggggat gagtgtatcctgaaggacaacaacgagcgcagcaagtggtacgtgacgggcccgggaggc gttgacatgcttgttccctctgtggggctgatcatccctcctccgaacccactggccgtg gacctctcttgcaagattgagcagtactacgaagccatcttggctctgtggaaccagctc tacatcaacatgaagagcctggtgtcctggcactactgcatgattgacatagagaagatc agggccatgacaatcgccaagctgaaaacaatgcggcaggaagattacatgaagacgata gccgaccttgagttacattaccaagagttcatcagaaatagccaaggctcagagatgttt ggagatgatgacaagcggaaaatacagtctcagttcaccgatgcccagaagcattaccag accctggtcattcagctccctggctatccccagcaccagacagtgaccacaactgaaatc actcatcatggaacctgccaagatgtcaaccataataaagtaattgaaaccaacagagaa aatgacaagcaagaaacatggatgctgatggagctgcagaagattcgcaggcagatagag cactgcgagggcaggatgactctcaaaaacctccctctagcagaccaggggtcttctcac cacatcacagtgaaaattaacgagcttaagagtgtgcagaatgattcacaagcaattgct gaggttctcaaccagcttaaagatatgcttgccaacttcagaggttctgaaaagtactgc tatttacagaatgaagtatttggactatttcagaaactggaaaatatcaatggtgttaca gatggctacttaaatagcttatgcacagtaagggcactgctccaggctattctccaaaca gaagacatgttaaaggtttatgaagccaggctcactgaggaggaaactgtctgcctggac ctggataaagtggaagcttaccgctgtggactgaagaaaataaaaaatgacttgaacttg aagaagtcgttgttggccactatgaagacagaactacagaaagcccagcagatccactct cagacttcacagcagtatccactttatgatctggacttgggcaagttcggtgaaaaagtc acacagctgacagaccgctggcaaaggatagataaacagatcgactttaggttatgggac ctggagaaacaaatcaagcaattgaggaattatcgtgataactatcaggctttctgcaag tggctctatgatgctaaacgccgccaggattccttagaatccatgaaatttggagattcc aacacagtcatgcggtttttgaatgagcagaagaacttgcacagtgaaatatctggcaaa cgagacaaatcagaggaagtacaaaaaattgctgaactttgcgccaattcaattaaggat tatgagctccagctggcctcatacacctcaggactggaaactctgctgaacatacctatc aagaggaccatgattcagtccccttctggggtgattctgcaagaggctgcagatgttcat gctcggtacattgaactacttacaagatctggagactattacaggttcttaagtgagatg ctgaagagtttggaagatctgaagctgaaaaataccaagatcgaagttttggaagaggag ctcagactggcccgagatgccaactcggaaaactgtaataagaacaaattcctggatcag aacctgcagaaataccaggcagagtgttcccagttcaaagcgaagcttgcgagcctggag gagctgaagagacaggctgagctggatgggaagtcggctaagcaaaatctagacaagtgc tacggccaaataaaagaactcaatgagaagatcacccgactgacttatgagattgaagat gaaaagagaagaagaaaatctgtggaagacagatttgaccaacagaagaatgactatgac caactgcagaaagcaaggcaatgtgaaaaggagaaccttggttggcagaaattagagtct gagaaagccatcaaggagaaggagtacgagattgaaaggttgagggttctactgcaggaa gaaggcacccggaagagagaatatgaaaatgagctggcaaaggcatctaataggattcag gaatcaaagaatcagtgtactcaggtggtacaggaaagagagagccttctggtgaaaatc aaagtcctggagcaagacaaggcaaggctgcagaggctggaggatgagctgaatcgtgca aaatcaactctagaggcagaaaccagggtgaaacagcgcctggagtgtgagaaacagcaa attcagaatgacctgaatcagtggaagactcaatattcccgcaaggaggaggctattagg aagatagaatcggaaagagaaaagagtgagagagagaagaacagtcttaggagtgagatc gaaagactccaagcagagatcaagagaattgaagagaggtgcaggcgtaagctggaggat tctaccagggagacacagtcacagttagaaacagaacgctcccgatatcagagggagatt gataaactcagacagcgcccatatgggtcccatcgagagacccagactgagtgtgagtgg accgttgacacctccaagctggtgtttgatgggctgaggaagaaggtgacagcaatgcag ctctatgagtgtcagctgatcgacaaaacaaccttggacaaactattgaaggggaagaag tcagtggaagaagttgcttctgaaatccagccattccttcggggtgcaggatctatcgct ggagcatctgcttctcctaaggaaaaatactctttggtagaggccaagagaaagaaatta atcagcccagaatccacagtcatgcttctggaggcccaggcagctacaggtggtataatt gatccccatcggaatgagaagctgactgtcgacagtgccatagctcgggacctcattgac ttcgatgaccgtcagcagatatatgcagcagaaaaagctatcactggttttgatgatcca ttttcaggcaagacagtatctgtttcagaagccatcaagaaaaatttgattgatagagaa accggaatgcgcctgctggaagcccagattgcttcagggggtgtagtagaccctgtgaac agtgtctttttgccaaaagatgtcgccttggcccgggggctgattgatagagatttgtat cgatccctgaatgatccccgagatagtcagaaaaactttgtggatccagtcaccaaaaag aaggtcagttacgtgcagctgaaggaacggtgcagaatcgaaccacatactggtctgctc ttgctttcagtacagaagagaagcatgtccttccaaggaatcagacaacctgtgaccgtc actgagctagtagattctggtatattgagaccgtccactgtcaatgaactggaatctggt cagatttcttatgacgaggttggtgagagaattaaggacttcctccagggttcaagctgc atagcaggcatatacaatgagaccacaaaacagaagcttggcatttatgaggccatgaaa attggcttagtccgacctggtactgctctggagttgctggaagcccaagcagctactggc tttatagtggatcctgttagcaacttgaggttaccagtggaggaagcctacaagagaggt ctggtgggcattgagttcaaagagaagctcctgtctgcagaacgagctgtcactgggtat aatgatcctgaaacaggaaacatcatctctttgttccaagccatgaataaggaactcatc gaaaagggccacggtattcgcttattagaagcacagatcgcaaccggggggatcattgac ccaaaggagagccatcgtttaccagttgacatagcatataagaggggctatttcaatgag gaactcagtgagattctctcagatccaagtgatgataccaaaggattttttgaccccaac actgaagaaaatcttacctatctgcaactaaaagaaagatgcattaaggatgaggaaaca gggctctgtcttctgcctctgaaagaaaagaagaaacaggtgcagacatcacaaaagaat accctcaggaagcgtagagtggtcatagttgacccagaaaccaataaagaaatgtctgtt caggaggcctacaagaagggcctaattgattatgaaaccttcaaagaactgtgtgagcag gaatgtgaatgggaagaaataaccatcacgggatcagatggctccaccagggtggtcctg gtagatagaaagacaggcagtcagtatgatattcaagatgctattgacaagggccttgtt gacaggaagttctttgatcagtaccgatccggcagcctcagcctcactcaatttgctgac atgatctccttgaaaaatggtgtcggcaccagcagcagcatgggcagtggtgtcagcgat gatgtttttagcagctcccgacatgaatcagtaagtaagatttccaccatatccagcgtc aggaatttaaccataaggagcagctctttttcagacaccctggaagaatcgagccccatt gcagccatctttgacacagaaaacctggagaaaatctccattacagaaggtatagagcgg ggcatcgttgacagcatcacgggtcagaggcttctggaggctcaggcctgcacaggtggc atcatccacccaaccacgggccagaagctgtcacttcaggacgcagtctcccagggtgtg attgaccaagacatggccaccaggctgaagcctgctcagaaagccttcataggcttcgag ggtgtgaagggaaagaagaagatgtcagcagcagaggcagtgaaagaaaaatggctcccg tatgaggctggccagcgcttcctggagttccagtacctcacgggaggtcttgttgacccg gaagtgcatgggaggataagcaccgaagaagccatccggaaggggttcatagatggccgc gccgcacagaggctgcaagacaccagcagctatgccaaaatcctgacctgccccaaaacc aaattaaaaatatcctataaggatgccataaatcgctccatggtagaagatatcactggg ctgcgccttctggaagccgcctccgtgtcgtccaagggcttacccagcccttacaacatg tcttcggctccggggtcccgctccggctcccgctcgggatctcgctccggatctcgctcc gggtcccgcagtgggtcccggagaggaagctttgacgccacagggaattcttcctactct tattcctactcatttagcagtagttctattgggcactag |
Protein Sequence |
>1832 : length: 2272 MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH |