| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1869 |
Name | E2F1 |
Synonym | E2F-1|RBAP1|RBBP3|RBP3;E2F transcription factor 1;E2F1;E2F transcription factor 1 |
Definition | PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1 |
Position | 20q11.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6277 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | e2f1 destruction pathway;PID BioCarta;100034 |
Pathway | tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | mets affect on macrophage differentiation;PID BioCarta;100169 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | p53 signaling pathway;PID BioCarta;100083 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | cyclin e destruction pathway;PID BioCarta;100166 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | regulation of p27 phosphorylation during cell cycle progression;PID BioCarta;100087 |
Disease | Lung carcinomas;GAD |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
Disease | HIV infection;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | Parkinson disease;FunDO |
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External Links |
|
Links to Entrez Gene | 1869 |
Links to all GeneRIF Items | 1869 |
Links to iHOP | 1869 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1869 : length: 1314 atggccttggccggggcccctgcgggcggcccatgcgcgccggcgctggaggccctgctc ggggccggcgcgctgcggctgctcgactcctcgcagatcgtcatcatctccgccgcgcag gacgccagcgccccgccggctcccaccggccccgcggcgcccgccgccggcccctgcgac cctgacctgctgctcttcgccacaccgcaggcgccccggcccacacccagtgcgccgcgg cccgcgctcggccgcccgccggtgaagcggaggctggacctggaaactgaccatcagtac ctggccgagagcagtgggccagctcggggcagaggccgccatccaggaaaaggtgtgaaa tccccgggggagaagtcacgctatgagacctcactgaatctgaccaccaagcgcttcctg gagctgctgagccactcggctgacggtgtcgtcgacctgaactgggctgccgaggtgctg aaggtgcagaagcggcgcatctatgacatcaccaacgtccttgagggcatccagctcatt gccaagaagtccaagaaccacatccagtggctgggcagccacaccacagtgggcgtcggc ggacggcttgaggggttgacccaggacctccgacagctgcaggagagcgagcagcagctg gaccacctgatgaatatctgtactacgcagctgcgcctgctctccgaggacactgacagc cagcgcctggcctacgtgacgtgtcaggaccttcgtagcattgcagaccctgcagagcag atggttatggtgatcaaagcccctcctgagacccagctccaagccgtggactcttcggag aactttcagatctcccttaagagcaaacaaggcccgatcgatgttttcctgtgccctgag gagaccgtaggtgggatcagccctgggaagaccccatcccaggaggtcacttctgaggag gagaacagggccactgactctgccaccatagtgtcaccaccaccatcatctcccccctca tccctcaccacagatcccagccagtctctactcagcctggagcaagaaccgctgttgtcc cggatgggcagcctgcgggctcccgtggacgaggaccgcctgtccccgctggtggcggcc gactcgctcctggagcatgtgcgggaggacttctccggcctcctccctgaggagttcatc agcctttccccaccccacgaggccctcgactaccacttcggcctcgaggagggcgagggc atcagagacctcttcgactgtgactttggggacctcacccccctggatttctga |
Protein Sequence |
>1869 : length: 437 MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG IRDLFDCDFGDLTPLDF |