| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2050 |
Name | EPHB4 |
Synonym | HTK|MYK1|TYRO11;EPH receptor B4;EPHB4;EPH receptor B4 |
Definition | ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK |
Position | 7q22 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6582 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | EphrinB-EPHB pathway;PID Curated;200141 |
Disease | Cancer;FunDO |
|
External Links |
|
Links to Entrez Gene | 2050 |
Links to all GeneRIF Items | 2050 |
Links to iHOP | 2050 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2050 : length: 2964 atggagctccgggtgctgctctgctgggcttcgttggccgcagctttggaagagaccctg ctgaacacaaaattggaaactgctgatctgaagtgggtgacattccctcaggtggacggg cagtgggaggaactgagcggcctggatgaggaacagcacagcgtgcgcacctacgaagtg tgtgacgtgcagcgtgccccgggccaggcccactggcttcgcacaggttgggtcccacgg cggggcgccgtccacgtgtacgccacgctgcgcttcaccatgctcgagtgcctgtccctg cctcgggctgggcgctcctgcaaggagaccttcaccgtcttctactatgagagcgatgcg gacacggccacggccctcacgccagcctggatggagaacccctacatcaaggtggacacg gtggccgcggagcatctcacccggaagcgccctggggccgaggccaccgggaaggtgaat gtcaagacgctgcgtctgggaccgctcagcaaggctggcttctacctggccttccaggac cagggtgcctgcatggccctgctatccctgcacctcttctacaaaaagtgcgcccagctg actgtgaacctgactcgattcccggagactgtgcctcgggagctggttgtgcccgtggcc ggtagctgcgtggtggatgccgtccccgcccctggccccagccccagcctctactgccgt gaggatggccagtgggccgaacagccggtcacgggctgcagctgtgctccggggttcgag gcagctgaggggaacaccaagtgccgagcctgtgcccagggcaccttcaagcccctgtca ggagaagggtcctgccagccatgcccagccaatagccactctaacaccattggatcagcc gtctgccagtgccgcgtcgggtacttccgggcacgcacagacccccggggtgcaccctgc accacccctccttcggctccgcggagcgtggtttcccgcctgaacggctcctccctgcac ctggaatggagtgcccccctggagtctggtggccgagaggacctcacctacgccctccgc tgccgggagtgccgacccggaggctcctgtgcgccctgcgggggagacctgacttttgac cccggcccccgggacctggtggagccctgggtggtggttcgagggctacgtcctgacttc acctatacctttgaggtcactgcattgaacggggtatcctccttagccacggggcccgtc ccatttgagcctgtcaatgtcaccactgaccgagaggtacctcctgcagtgtctgacatc cgggtgacgcggtcctcacccagcagcttgagcctggcctgggctgttccccgggcaccc agtggggctgtgctggactacgaggtcaaataccatgagaagggcgccgagggtcccagc agcgtgcggttcctgaagacgtcagaaaaccgggcagagctgcgggggctgaagcgggga gccagctacctggtgcaggtacgggcgcgctctgaggccggctacgggcccttcggccag gaacatcacagccagacccaactggatgagagcgagggctggcgggagcagctggccctg attgcgggcacggcagtcgtgggtgtggtcctggtcctggtggtcattgtggtcgcagtt ctctgcctcaggaagcagagcaatgggagagaagcagaatattcggacaaacacggacag tatctcatcggacatggtactaaggtctacatcgaccccttcacttatgaagaccctaat gaggctgtgagggaatttgcaaaagagatcgatgtctcctacgtcaagattgaagaggtg attggtgcaggtgagtttggcgaggtgtgccgggggcggctcaaggccccagggaagaag gagagctgtgtggcaatcaagaccctgaagggtggctacacggagcggcagcggcgtgag tttctgagcgaggcctccatcatgggccagttcgagcaccccaatatcatccgcctggag ggcgtggtcaccaacagcatgcccgtcatgattctcacagagttcatggagaacggcgcc ctggactccttcctgcggctaaacgacggacagttcacagtcatccagctcgtgggcatg ctgcggggcatcgcctcgggcatgcggtaccttgccgagatgagctacgtccaccgagac ctggctgctcgcaacatcctagtcaacagcaacctcgtctgcaaagtgtctgactttggc ctttcccgattcctggaggagaactcttccgatcccacctacacgagctccctgggagga aagattcccatccgatggactgccccggaggccattgccttccggaagttcacttccgcc agtgatgcctggagttacgggattgtgatgtgggaggtgatgtcatttggggagaggccg tactgggacatgagcaatcaggacgtgatcaatgccattgaacaggactaccggctgccc ccgcccccagactgtcccacctccctccaccagctcatgctggactgttggcagaaagac cggaatgcccggccccgcttcccccaggtggtcagcgccctggacaagatgatccggaac cccgccagcctcaaaatcgtggcccgggagaatggcggggcctcacaccctctcctggac cagcggcagcctcactactcagcttttggctctgtgggcgagtggcttcgggccatcaaa atgggaagatacgaagaaagtttcgcagccgctggctttggctccttcgagctggtcagc cagatctctgctgaggacctgctccgaatcggagtcactctggcgggacaccagaagaaa atcttggccagtgtccagcacatgaagtcccaggccaagccgggaaccccgggtgggaca ggaggaccggccccgcagtactga |
Protein Sequence |
>2050 : length: 987 MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEV CDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDA DTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQD QGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCR EDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSA VCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALR CRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPV PFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPS SVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAL IAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPN EAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE FLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGM LRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGG KIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP PPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLD QRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKK ILASVQHMKSQAKPGTPGGTGGPAPQY |