| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2132 |
Name | EXT2 |
Synonym | SOTV;exostosin glycosyltransferase 2;EXT2;exostosin glycosyltransferase 2 |
Definition | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostosin-2|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 2|putative tumor suppressor pr |
Position | 11p12-p11 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6721 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Glycosaminoglycan biosynthesis - heparan sulfate;KEGG PATHWAY;hsa00534 |
Pathway | heparan sulfate biosynthesis;BioCyc;PWY-6564 |
Pathway | heparan sulfate biosynthesis (late stages);BioCyc;PWY-6558 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Disease | diabetes, type 2;GAD |
Disease | Hereditary multiple exostoses;GAD |
Disease | Genetic disorders;KEGG DISEASE |
Disease | Exostoses, multiple, type 2;OMIM |
Disease | Congenital abnormality;FunDO |
Disease | METABOLIC;GAD |
Disease | Multiple exostoses;KEGG DISEASE;H00122 |
Disease | Inherited disorders of glycan/glycoprotein metabolism;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 2132 |
Links to all GeneRIF Items | 2132 |
Links to iHOP | 2132 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2132 : length: 2256 atgtcctgcgcctcagggtccggtggtggcctgcggcatcccttgcggtgccagaagccg tgggacgaggagtgtgaggaagaggctgtctgtgtcattatgtgtgcgtcggtcaagtat aatatccggggtcctgccctcatcccaagaatgaagaccaagcaccgaatctactatatc accctcttctccattgtcctcctgggcctcattgccactggcatgtttcagttttggccc cattctatcgagtcctcaaatgactggaatgtagagaagcgcagcatccgtgatgtgccg gttgttaggctgccagccgacagtcccatcccagagcggggggatctcagttgcagaatg cacacgtgttttgatgtctatcgctgtggcttcaacccaaagaacaaaatcaaggtgtat atctatgctctgaaaaagtacgtggatgactttggcgtctctgtcagcaacaccatctcc cgggagtataatgaactgctcatggccatctcagacagtgactactacactgatgacatc aaccgggcctgtctgtttgttccctccatcgatgtgcttaaccagaacacactgcgcatc aaggagacagcacaagcgatggcccagctctctaggtgggatcgaggtacgaatcacctg ttgttcaacatgttgcctggaggtcccccagattataacacagccctggatgtccccaga gacagggccctgttggctggtggcggcttttctacgtggacttaccggcaaggctacgat gtcagcattcctgtctatagtccactgtcagctgaggtggatcttccagagaaaggacca ggtccacggcaatacttcctcctgtcatctcaggtgggtctccatcctgagtacagagag gacctagaagccctccaggtcaaacatggagagtcagtgttagtactcgataaatgcacc aacctctcagagggtgtcctttctgtccgtaagcgctgccacaagcaccaggtcttcgat tacccacaggtgctacaggaggctactttctgtgtggttcttcgtggagctcggctgggc caggcagtattgagcgatgtgttacaagctggctgtgtcccggttgtcattgcagactcc tatattttgcctttctctgaagttcttgactggaagagagcatctgtggttgtaccagaa gaaaagatgtcagatgtgtacagtattttgcagagcatcccccaaagacagattgaagaa atgcagagacaggcccggtggttctgggaagcgtacttccagtcaattaaagccattgcc ctggccaccctgcagattatcaatgaccggatctatccatatgctgccatctcctatgaa gaatggaatgaccctcctgctgtgaagtggggcagcgtgagcaatccactcttcctcccg ctgatcccaccacagtctcaagggttcaccgccatagtcctcacctacgaccgagtagag agcctcttccgggtcatcactgaagtgtccaaggtgcccagtctatccaaactacttgtc gtctggaataatcagaataaaaaccctccagaagattctctctggcccaaaatccgggtt ccattaaaagttgtgaggactgctgaaaacaagttaagtaaccgtttcttcccttatgat gaaatcgagacagaagctgttctggccattgatgatgatatcattatgctgacctctgac gagctgcaatttggttatgaggtctggcgggaatttcctgaccggttggtgggttacccg ggtcgtctgcatctctgggaccatgagatgaataagtggaagtatgagtctgagtggacg aatgaagtgtccatggtgctcactggggcagctttttatcacaagtattttaattacctg tatacctacaaaatgcctggggatatcaagaactgggtagatgctcatatgaactgtgaa gatattgccatgaacttcctggtggccaacgtcacgggaaaagcagttatcaaggtaacc ccacgaaagaaattcaagtgtcctgagtgcacagccatagatgggctttcactagaccaa acacacatggtggagaggtcagagtgcatcaacaagtttgcttcagtcttcgggaccatg cctctcaaggtggtggaacaccgagctgaccctgtcctgtacaaagatgactttcctgag aagctgaagagcttccccaacattggcagcttatga |
Protein Sequence |
>2132 : length: 751 MSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYI TLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRM HTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDI NRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPR DRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYRE DLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLG QAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEE MQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLP LIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRV PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCE DIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTM PLKVVEHRADPVLYKDDFPEKLKSFPNIGSL |