| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 231 |
Name | AKR1B1 |
Synonym | ADR|ALDR1|ALR2|AR;aldo-keto reductase family 1, member B1 (aldose reductase);AKR1B1;aldo-keto reductase family 1, member B1 (aldose reductase) |
Definition | Lii5-2 CTCL tumor antigen|aldehyde reductase 1|aldo-keto reductase family 1 member B1|aldose reductase|low Km aldose reductase |
Position | 7q35 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 2615 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Fructose and mannose metabolism;KEGG PATHWAY;hsa00051 |
Pathway | Galactose metabolism;KEGG PATHWAY;hsa00052 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Pentose and glucuronate interconversions;KEGG PATHWAY;hsa00040 |
Pathway | methylglyoxal degradation III;BioCyc;PWY-5453 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Glycerolipid metabolism;KEGG PATHWAY;hsa00561 |
Pathway | Pyruvate metabolism;KEGG PATHWAY;hsa00620 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | Pregnenolone biosynthesis;PID Reactome;500773 |
Pathway | acetone degradation I (to methylglyoxal);BioCyc;PWY-5451 |
Disease | Ischemia;FunDO |
Disease | Common cold;FunDO |
Disease | retinopathy, diabetic;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | RENAL;GAD |
Disease | VISION;GAD |
Disease | nephropathy in other diseases;GAD |
Disease | Adrenal gland tumor;FunDO |
Disease | METABOLIC;GAD |
Disease | Pancreas disease;FunDO |
Disease | Metabolism disease;FunDO |
Disease | diabetes, type 2;GAD |
Disease | Colon cancer;FunDO |
Disease | Atherosclerosis;FunDO |
|
External Links |
|
Links to Entrez Gene | 231 |
Links to all GeneRIF Items | 231 |
Links to iHOP | 231 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>231 : length: 951 atggcaagccgtctcctgctcaacaacggcgccaagatgcccatcctggggttgggtacc tggaagtcccctccagggcaggtgactgaggccgtgaaggtggccattgacgtcgggtac cgccacatcgactgtgcccatgtgtaccagaatgagaatgaggtgggggtggccattcag gagaagctcagggagcaggtggtgaagcgtgaggagctcttcatcgtcagcaagctgtgg tgcacgtaccatgagaagggcctggtgaaaggagcctgccagaagacactcagcgacctg aagctggactacctggacctctaccttattcactggccgactggctttaagcctgggaag gaatttttcccattggatgagtcgggcaatgtggttcccagtgacaccaacattctggac acgtgggcggccatggaagagctggtggatgaagggctggtgaaagctattggcatctcc aacttcaaccatctccaggtggagatgatcttaaacaaacctggcttgaagtataagcct gcagttaaccagattgagtgccacccatatctcactcaggagaagttaatccagtactgc cagtccaaaggcatcgtggtgaccgcctacagccccctcggctctcctgacaggccctgg gccaagcccgaggacccttctctcctggaggatcccaggatcaaggcgatcgcagccaag cacaataaaactacagcccaggtcctgatccggttccccatgcagaggaacttggtggtg atccccaagtctgtgacaccagaacgcattgctgagaactttaaggtctttgactttgaa ctgagcagccaggatatgaccaccttactcagctacaacaggaactggagggtctgtgcc ttgttgagctgtacctcccacaaggattaccccttccatgaagagttttga |
Protein Sequence |
>231 : length: 316 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA LLSCTSHKDYPFHEEF |