| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2322 |
Name | FLT3 |
Synonym | CD135|FLK-2|FLK2|STK1;fms-related tyrosine kinase 3;FLT3;fms-related tyrosine kinase 3 |
Definition | CD135 antigen|FL cytokine receptor|fetal liver kinase 2|fms-like tyrosine kinase 3|growth factor receptor tyrosine kinase type III|receptor-type tyrosine-protein kinase FLT3|stem cell tyrosine kinase 1 |
Position | 13q12 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 7274 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
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Pathways and Diseases |
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Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Cancers;KEGG DISEASE |
Disease | leukemia;GAD |
Disease | Leukemia, acute lymphoblastic;OMIM |
Disease | Acute myeloid leukemia (AML);KEGG DISEASE;H00003 |
Disease | Leukemia, acute myeloid;OMIM |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | Osteoporosis;GAD |
Disease | Translocation, Genetic;GAD |
Disease | CANCER;GAD |
Disease | leukemia, myeloid;GAD |
Disease | METABOLIC;GAD |
Disease | Leukemia, acute myeloid, reduced survival in;OMIM |
Disease | Leukemia, Myeloid, Acute;GAD |
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External Links |
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Links to Entrez Gene | 2322 |
Links to all GeneRIF Items | 2322 |
Links to iHOP | 2322 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2322 : length: 2982 atgccggcgttggcgcgcgacggcggccagctgccgctgctcgttgttttttctgcaatg atatttgggactattacaaatcaagatctgcctgtgatcaagtgtgttttaatcaatcat aagaacaatgattcatcagtggggaagtcatcatcatatcccatggtatcagaatccccg gaagacctcgggtgtgcgttgagaccccagagctcagggacagtgtacgaagctgccgct gtggaagtggatgtatctgcttccatcacactgcaagtgctggtcgacgccccagggaac atttcctgtctctgggtctttaagcacagctccctgaattgccagccacattttgattta caaaacagaggagttgtttccatggtcattttgaaaatgacagaaacccaagctggagaa tacctactttttattcagagtgaagctaccaattacacaatattgtttacagtgagtata agaaataccctgctttacacattaagaagaccttactttagaaaaatggaaaaccaggac gccctggtctgcatatctgagagcgttccagagccgatcgtggaatgggtgctttgcgat tcacagggggaaagctgtaaagaagaaagtccagctgttgttaaaaaggaggaaaaagtg cttcatgaattatttgggacggacataaggtgctgtgccagaaatgaactgggcagggaa tgcaccaggctgttcacaatagatctaaatcaaactcctcagaccacattgccacaatta tttcttaaagtaggggaacccttatggataaggtgcaaagctgttcatgtgaaccatgga ttcgggctcacctgggaattagaaaacaaagcactcgaggagggcaactactttgagatg agtacctattcaacaaacagaactatgatacggattctgtttgcttttgtatcatcagtg gcaagaaacgacaccggatactacacttgttcctcttcaaagcatcccagtcaatcagct ttggttaccatcgtagaaaagggatttataaatgctaccaattcaagtgaagattatgaa attgaccaatatgaagagttttgtttttctgtcaggtttaaagcctacccacaaatcaga tgtacgtggaccttctctcgaaaatcatttccttgtgagcaaaagggtcttgataacgga tacagcatatccaagttttgcaatcataagcaccagccaggagaatatatattccatgca gaaaatgatgatgcccaatttaccaaaatgttcacgctgaatataagaaggaaacctcaa gtgctcgcagaagcatcggcaagtcaggcgtcctgtttctcggatggatacccattacca tcttggacctggaagaagtgttcagacaagtctcccaactgcacagaagagatcacagaa ggagtctggaatagaaaggctaacagaaaagtgtttggacagtgggtgtcgagcagtact ctaaacatgagtgaagccataaaagggttcctggtcaagtgctgtgcatacaattccctt ggcacatcttgtgagacgatccttttaaactctccaggccccttccctttcatccaagac aacatctcattctatgcaacaattggtgtttgtctcctcttcattgtcgttttaaccctg ctaatttgtcacaagtacaaaaagcaatttaggtatgaaagccagctacagatggtacag gtgaccggctcctcagataatgagtacttctacgttgatttcagagaatatgaatatgat ctcaaatgggagtttccaagagaaaatttagagtttgggaaggtactaggatcaggtgct tttggaaaagtgatgaacgcaacagcttatggaattagcaaaacaggagtctcaatccag gttgccgtcaaaatgctgaaagaaaaagcagacagctctgaaagagaggcactcatgtca gaactcaagatgatgacccagctgggaagccacgagaatattgtgaacctgctgggggcg tgcacactgtcaggaccaatttacttgatttttgaatactgttgctatggtgatcttctc aactatctaagaagtaaaagagaaaaatttcacaggacttggacagagattttcaaggaa cacaatttcagtttttaccccactttccaatcacatccaaattccagcatgcctggttca agagaagttcagatacacccggactcggatcaaatctcagggcttcatgggaattcattt cactctgaagatgaaattgaatatgaaaaccaaaaaaggctggaagaagaggaggacttg aatgtgcttacatttgaagatcttctttgctttgcatatcaagttgccaaaggaatggaa tttctggaatttaagtcgtgtgttcacagagacctggccgccaggaacgtgcttgtcacc cacgggaaagtggtgaagatatgtgactttggattggctcgagatatcatgagtgattcc aactatgttgtcaggggcaatgcccgtctgcctgtaaaatggatggcccccgaaagcctg tttgaaggcatctacaccattaagagtgatgtctggtcatatggaatattactgtgggaa atcttctcacttggtgtgaatccttaccctggcattccggttgatgctaacttctacaaa ctgattcaaaatggatttaaaatggatcagccattttatgctacagaagaaatatacatt ataatgcaatcctgctgggcttttgactcaaggaaacggccatccttccctaatttgact tcgtttttaggatgtcagctggcagatgcagaagaagcgatgtatcagaatgtggatggc cgtgtttcggaatgtcctcacacctaccaaaacaggcgacctttcagcagagagatggat ttggggctactctctccgcaggctcaggtcgaagattcgtag |
Protein Sequence |
>2322 : length: 993 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS |