| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 23327 |
Name | NEDD4L |
Synonym | NEDD4-2|NEDD4.2|RSP5|hNEDD4-2;neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase;NEDD4L;neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase NEDD4-like|ubiquitin-protein ligase Rsp5 |
Position | 18q21.31 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 11273 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Disease | Hypotension, Orthostatic;GAD |
Disease | RENAL;GAD |
Disease | hypertension;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | renin activity salt sensitivity;GAD |
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External Links |
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Links to Entrez Gene | 23327 |
Links to all GeneRIF Items | 23327 |
Links to iHOP | 23327 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>23327 : length: 2565 atggagcgaccctatacatttaaggactttctcctcagaccaagaagtcataagtctcga gttaagggatttttgcgattgaaaatggcctatatgccaaaaaatggaggtcaagatgaa gaaaacagtgaccagagggatgacatggagcatggatgggaagttgttgactcaaatgac tcggcttctcagcaccaagaggaacttcctcctcctcctctgcctcccgggtgggaagaa aaagtggacaatttaggccgaacttactatgtcaaccacaacaaccggaccactcagtgg cacagaccaagcctgatggacgtgtcctcggagtcggacaataacatcagacagatcaac caggaggcagcacaccggcgcttccgctcccgcaggcacatcagcgaagacttggagccc gagccctcggagggcggggatgtccccgagccttgggagaccatttcagaggaagtgaat atcgctggagactctctcggtctggctctgcccccaccaccggcctccccaggatctcgg accagccctcaggagctgtcagaggaactaagcagaaggcttcagatcactccagactcc aatggggaacagttcagctctttgattcaaagagaaccctcctcaaggttgaggtcatgc agtgtcaccgacgcagttgcagaacagggccatctaccaccgcccagtgccccagctggg agagcgcgttcatcaactgtcacgggtggtgaggaaccaacgccatcagtggcctatgta cataccacgccgggtctgccttcaggctgggaagaaagaaaagatgctaaggggcgcaca tactatgtcaatcataacaatcgaaccacaacttggactcgacctatcatgcagcttgca gaagatggtgcgtccggatcagccacaaacagtaacaaccatctaatcgagcctcagatc cgccggcctcgtagcctcagctcgccaacagtaactttatctgccccgctggagggtgcc aaggactcacccgtacgtcgggctgtgaaagacaccctttccaacccacagtccccacag ccatcaccttacaactcccccaaaccacaacacaaagtcacacagagcttcttgccaccc ggctgggaaatgaggatagcgccaaacggccggcccttcttcattgatcataacacaaag actacaacctgggaagatccacgtttgaaatttccagtacatatgcggtcaaagacatct ttaaaccccaatgaccttggcccccttcctcctggctgggaagaaagaattcacttggat ggccgaacgttttatattgatcataatagcaaaattactcagtgggaagacccaagactg cagaacccagctattactggtccggctgtcccttactccagagaatttaagcagaaatat gactacttcaggaagaaattaaagaaacctgctgatatccccaataggtttgaaatgaaa cttcacagaaataacatatttgaagagtcctatcggagaattatgtccgtgaaaagacca gatgtcctaaaagctagactgtggattgagtttgaatcagagaaaggtcttgactatggg ggtgtggccagagaatggttcttcttactgtccaaagagatgttcaacccctactacggc ctctttgagtactctgccacggacaactacacccttcagatcaaccctaattcaggcctc tgtaatgaggatcatttgtcctacttcacttttattggaagagttgctggtctggccgta tttcatgggaagctcttagatggtttcttcattagaccattttacaagatgatgttggga aagcagataaccctgaatgacatggaatctgtggatagtgaatattacaactctttgaaa tggatcctggagaatgaccctactgagctggacctcatgttctgcatagacgaagaaaac tttggacagacatatcaagtggatttgaagcccaatgggtcagaaataatggtcacaaat gaaaacaaaagggaatatatcgacttagtcatccagtggagatttgtgaacagggtccag aagcagatgaacgccttcttggagggattcacagaactacttcctattgatttgattaaa atttttgatgaaaatgagctggagttgctcatgtgcggcctcggtgatgtggatgtgaat gactggagacagcattctatttacaagaacggctactgcccaaaccaccccgtcattcag tggttctggaaggctgtgctactcatggacgccgaaaagcgtatccggttactgcagttt gtcacagggacatcgcgagtacctatgaatggatttgccgaactttatggttccaatggt cctcagctgtttacaatagagcaatggggcagtcctgagaaactgcccagagctcacaca tgctttaatcgccttgacttacctccatatgaaacctttgaagatttacgagagaaactt ctcatggccgtggaaaatgctcaaggatttgaaggggtggattaa |
Protein Sequence |
>23327 : length: 854 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL LMAVENAQGFEGVD |