Entrez Gene

Basic Information
Gene ID	23327
Name	NEDD4L
Synonymous	NEDD4-2\|NEDD4.2\|RSP5\|hNEDD4-2;neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase;NEDD4L;neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Definition	E3 ubiquitin-protein ligase NEDD4-like\|ubiquitin-protein ligase Rsp5
Position	18q21.31
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
Nedd4-2(h) + SGK-1(h) <==> Nedd4-2(h):SGK-1(h) (binding)
alphaENaC(h) + Nedd4-2(h) <==> alphaENaC(h):Nedd4-2(h) (binding)
Smad7(m) + Nedd4-2(h) <==> Smad7(m):Nedd4-2(h) (binding)
Nedd4-2(h) + Smad7(m.s.) <==> Nedd4-2(h):Smad7(m.s.) (binding)
Smad6(m.s.) + Nedd4-2(h) <==> Smad6(m.s.):Nedd4-2(h) (binding)
Nedd4-2(h) + Smad2(m.s.) <==> Nedd4-2(h):Smad2(m.s.) (binding)
Smad3(m.s.) + Nedd4-2(h) <==> Smad3(m.s.):Nedd4-2(h) (binding)
Smad1(m.s.) + Nedd4-2(h) <==> Smad1(m.s.):Nedd4-2(h) (binding)
Smad5(m.s.) + Nedd4-2(h) <==> Smad5(m.s.):Nedd4-2(h) (binding)
Smad7(m.s.) + Nedd4-2(h) + TGFbetaR-I(m.s.):TGFbetaR-II(m.s.) <==> Smad7(m.s.):Nedd4-2(h):TGFbetaR-I(m.s.):TGFbetaR-II(m.s.) (binding)
Nedd4-2(h) + Smad2(m.s.) + SnoN(m.s.) <==> Nedd4-2(h):Smad2(m.s.):SnoN(m.s.) (binding)
trkA(r) + Nedd4-2(h) <==> trkA(r):Nedd4-2(h) (binding)
14-3-3sigma(m.s.) + Nedd4-2(h) <==> 14-3-3sigma(m.s.):Nedd4-2(h) (binding)
NEDD4L(h) --> Nedd4-2(h) (expression).
trkA(r) + ubiquitin(b) --E1(rb),Ubc5B(rb),Nedd4-2(h)--> trkA(r){ub} (ubiquitination)
trkA(r) + ubiquitin(h) --Nedd4-2(h)--> trkA(r){ub} (ubiquitination)
NEDD4L(h) --> Nedd4-2-xbb1(h) (expression).
NEDD4L(h) --> Nedd4-2-isoform4(h) (expression).
NEDD4L(h) --> Nedd4-2-isoform5(h) (expression).
NEDD4L(h) --> Nedd4-2-isoform1(h) (expression).
NEDD4L(h) --> Nedd4-2-isoform6(h) (expression).
NEDD4L(h) --> Nedd4-2-isoform7(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
302	Phosphothreonine (By similarity).		Swiss-Prot 53.0
342	Phosphoserine (by PKA) (Probable).		Swiss-Prot 53.0
367	Phosphothreonine (by SGK) (Probable).		Swiss-Prot 53.0
446	Phosphoserine (By similarity).		Swiss-Prot 53.0
448	Phosphoserine (by PKA and SGK).		Swiss-Prot 53.0
479	Phosphoserine.		Swiss-Prot 53.0
483	Phosphoserine.		Swiss-Prot 53.0
487	Phosphoserine.		Swiss-Prot 53.0
449	Phosphoserine	17081983	Phospho.ELM 6.0
479	Phosphoserine	17081983	Phospho.ELM 6.0
483	Phosphoserine	17081983	Phospho.ELM 6.0
487	Phosphoserine	17081983	Phospho.ELM 6.0