| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 249 |
Name | ALPL |
Synonym | AP-TNAP|APTNAP|HOPS|TNAP|TNSALP;alkaline phosphatase, liver/bone/kidney;ALPL;alkaline phosphatase, liver/bone/kidney |
Definition | alkaline phosphatase liver/bone/kidney isozyme|alkaline phosphatase, tissue-nonspecific isozyme|alkaline phosphomonoesterase|glycerophosphatase|liver/bone/kidney-type alkaline phosphatase|tissue-nonspecific ALP |
Position | 1p36.12 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 881 |
TUSON P-value | 0.034218691 |
|
Pathways and Diseases |
|
Pathway | Folate biosynthesis;KEGG PATHWAY;hsa00790 |
Pathway | regulators of bone mineralization;PID BioCarta;100089 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Disease | Periodontal disease;FunDO |
Disease | Hypophosphatasia, adult;OMIM |
Disease | bone density;GAD |
Disease | Inherited disorders of cofactor/vitamin metabolism;KEGG DISEASE |
Disease | Genetic disorders;KEGG DISEASE |
Disease | Bone disease;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Serum phosphorus concentrations;NHGRI |
Disease | Osteoporosis;FunDO |
Disease | Hypophosphatasia;KEGG DISEASE;H00213 |
Disease | folate pathway vitamin levels;GAD |
Disease | Meningioma;FunDO |
Disease | Hypophosphatasia, childhood;OMIM |
Disease | Folate pathway vitamin levels;NHGRI |
Disease | Congenital abnormality;FunDO |
Disease | Liver disease;FunDO |
Disease | METABOLIC;GAD |
Disease | Odontohypophosphatasia;OMIM |
Disease | plasma levels of liver enzymes;GAD |
Disease | Kidney disease;FunDO |
Disease | Hypophosphatasia, infantile;OMIM |
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External Links |
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Links to Entrez Gene | 249 |
Links to all GeneRIF Items | 249 |
Links to iHOP | 249 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>249 : length: 1575 atgatttcaccattcttagtactggccattggcacctgccttactaactccttagtgcca gagaaagagaaagaccccaagtactggcgagaccaagcgcaagagacactgaaatatgcc ctggagcttcagaagctcaacaccaacgtggctaagaatgtcatcatgttcctgggagat gggatgggtgtctccacagtgacggctgcccgcatcctcaagggtcagctccaccacaac cctggggaggagaccaggctggagatggacaagttccccttcgtggccctctccaagacg tacaacaccaatgcccaggtccctgacagcgccggcaccgccaccgcctacctgtgtggg gtgaaggccaatgagggcaccgtgggggtaagcgcagccactgagcgttcccggtgcaac accacccaggggaacgaggtcacctccatcctgcgctgggccaaggacgctgggaaatct gtgggcattgtgaccaccacgagagtgaaccatgccacccccagcgccgcctacgcccac tcggctgaccgggactggtactcagacaacgagatgccccctgaggccttgagccagggc tgtaaggacatcgcctaccagctcatgcataacatcagggacattgacgtgatcatgggg ggtggccggaaatacatgtaccccaagaataaaactgatgtggagtatgagagtgacgag aaagccaggggcacgaggctggacggcctggacctcgttgacacctggaagagcttcaaa ccgagatacaagcactcccacttcatctggaaccgcacggaactcctgacccttgacccc cacaatgtggactacctattgggtctcttcgagccaggggacatgcagtacgagctgaac aggaacaacgtgacggacccgtcactctccgagatggtggtggtggccatccagatcctg cggaagaaccccaaaggcttcttcttgctggtggaaggaggcagaattgaccacgggcac catgaaggaaaagccaagcaggccctgcatgaggcggtggagatggaccgggccatcggg caggcaggcagcttgacctcctcggaagacactctgaccgtggtcactgcggaccattcc cacgtcttcacatttggtggatacaccccccgtggcaactctatctttggtctggccccc atgctgagtgacacagacaagaagcccttcactgccatcctgtatggcaatgggcctggc tacaaggtggtgggcggtgaacgagagaatgtctccatggtggactatgctcacaacaac taccaggcgcagtctgctgtgcccctgcgccacgagacccacggcggggaggacgtggcc gtcttctccaagggccccatggcgcacctgctgcacggcgtccacgagcagaactacgtc ccccacgtgatggcgtatgcagcctgcatcggggccaacctcggccactgtgctcctgcc agctcggcaggcagccttgctgcaggccccctgctgctcgcgctggccctctaccccctg agcgtcctgttctga |
Protein Sequence |
>249 : length: 524 MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF |