| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2932 |
Name | GSK3B |
Synonym | -;glycogen synthase kinase 3 beta;GSK3B;glycogen synthase kinase 3 beta |
Definition | GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B |
Position | 3q13.3 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 662 |
TUSON P-value | 0.019261522 |
|
Pathways and Diseases |
|
Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | multi-step regulation of transcription by pitx2;PID BioCarta;100074 |
Pathway | Aurora A signaling;PID Curated;200166 |
Pathway | LKB1 signaling events;PID Curated;200061 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | segmentation clock;PID BioCarta;100146 |
Pathway | C-MYC pathway;PID Curated;200093 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | BMP receptor signaling;PID Curated;200123 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | CRMPs in Sema3A signaling;PID Reactome;500077 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | regulation of eif2;PID BioCarta;100179 |
Pathway | Signaling by Wnt;Reactome;REACT:11045 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | phosphoinositides and their downstream targets;PID BioCarta;100059 |
Pathway | wnt signaling pathway;PID BioCarta;100002 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Insulin-mediated glucose transport;PID Curated;200168 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | nfat and hypertrophy of the heart ;PID BioCarta;100098 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | deregulation of cdk5 in alzheimers disease;PID BioCarta;100086 |
Pathway | Hedgehog signaling pathway;KEGG PATHWAY;hsa04340 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Hedgehog signaling pathway;PANTHER;P00025 |
Disease | bipolar disorder;GAD |
Disease | PSYCH;GAD |
Disease | Alzheimers disease;GAD |
Disease | NEUROLOGICAL;GAD |
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External Links |
|
Links to Entrez Gene | 2932 |
Links to all GeneRIF Items | 2932 |
Links to iHOP | 2932 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2932 : length: 1263 atgtcagggcggcccagaaccacctcctttgcggagagctgcaagccggtgcagcagcct tcagcttttggcagcatgaaagttagcagagacaaggacggcagcaaggtgacaacagtg gtggcaactcctgggcagggtccagacaggccacaagaagtcagctatacagacactaaa gtgattggaaatggatcatttggtgtggtatatcaagccaaactttgtgattcaggagaa ctggtcgccatcaagaaagtattgcaggacaagagatttaagaatcgagagctccagatc atgagaaagctagatcactgtaacatagtccgattgcgttatttcttctactccagtggt gagaagaaagatgaggtctatcttaatctggtgctggactatgttccggaaacagtatac agagttgccagacactatagtcgagccaaacagacgctccctgtgatttatgtcaagttg tatatgtatcagctgttccgaagtttagcctatatccattcctttggaatctgccatcgg gatattaaaccgcagaacctcttgttggatcctgatactgctgtattaaaactctgtgac tttggaagtgcaaagcagctggtccgaggagaacccaatgtttcgtatatctgttctcgg tactatagggcaccagagttgatctttggagccactgattatacctctagtatagatgta tggtctgctggctgtgtgttggctgagctgttactaggacaaccaatatttccaggggat agtggtgtggatcagttggtagaaataatcaaggtcctgggaactccaacaagggagcaa atcagagaaatgaacccaaactacacagaatttaaattccctcaaattaaggcacatcct tggactaaggtcttccgaccccgaactccaccggaggcaattgcactgtgtagccgtctg ctggagtatacaccaactgcccgactaacaccactggaagcttgtgcacattcatttttt gatgaattacgggacccaaatgtcaaactaccaaatgggcgagacacacctgcactcttc aacttcaccactcaagaactgtcaagtaatccacctctggctaccatccttattcctcct catgctcggattcaagcagctgcttcaacccccacaaatgccacagcagcgtcagatgct aatactggagaccgtggacagaccaataatgctgcttctgcatcagcttccaactccacc tga |
Protein Sequence |
>2932 : length: 420 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST |