| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 2932 |
Name | GSK3B |
Synonymous | -;glycogen synthase kinase 3 beta;GSK3B;glycogen synthase kinase 3 beta |
Definition | GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B |
Position | 3q13.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
FRATide(h) + GSK3beta(h) <==> FRATide(h):GSK3beta(h) (binding) | apc(h) + axin(m) + GSK3beta(h) <==> apc(h):axin(m):GSK3beta(h) (binding) | axin(m) + beta-catenin(h) + GSK3beta(h) <==> axin(m):beta-catenin(h):GSK3beta(h) (binding) | GSK3beta(h) + PS1(h) + Tau(h) <==> GSK3beta(h):PS1(h):Tau(h) (binding) | apc(h) + axin(h) + beta-catenin(h) + GSK3beta(h) <==> apc(h):axin(h):beta-catenin(h):GSK3beta(h) (binding) | GSK3beta(h) + NTP --AKT-1(h){pT308}{pS473}--> GSK3beta(h){pS9} + NDP (phosphorylation) | PKAc(h) + GSK3beta(h) <==> PKAc(h):GSK3beta(h) (binding) | PKAc(m) + GSK3beta(h) <==> PKAc(m):GSK3beta(h) (binding) | tuberin(h) + GSK3beta(h) <==> tuberin(h):GSK3beta(h) (binding) | axin(h) + GSK3beta(h) + PR65(h) + PP2ACalpha(h) + beta-catenin(h) <==> axin(h):beta-catenin(h):GSK3beta(h):PP2ACalpha(h):PR65(h) (binding) | axin(h) + GSK3beta(h) <==> axin(h):GSK3beta(h) (binding) | GSK3beta(h) + Frat1(h) <==> Frat1(h):GSK3beta(h) (binding) | GSK3beta(h) + Frat1(m) <==> Frat1(m):GSK3beta(h) (binding) | 2 GSK3beta(h) <==> GSK3beta(h):GSK3beta(h) (binding) | GSK3beta(h) + SNA(h) <==> GSK3beta(h):SNA(h) (binding) | GSK3beta(h) --> AR(m.s.) (regulation of protein activity) | GSK3beta(h) + 2 ATP --> GSK3beta(h){pS9}{pY216} + 2 ADP (phosphorylation) | GSK3beta(h) + ATP --> GSK3beta(h){p} + ADP (phosphorylation) | GSK3beta(h) + ATP --> GSK3beta(h){pS9} + ADP (phosphorylation) | GSK3beta(h) --/ p53(h) (decrease of abundance) | GSK3beta(h) --/ TP53(h) (transrepression) | GSK3beta(h) + MEKK1(h) <==> GSK3beta(h):MEKK1(h) (binding) | p53-isoform1(h) + GSK3beta(h) <==> p53-isoform1(h):GSK3beta(h) (binding) | p53(h) + GSK3beta(h) <==> p53(h):GSK3beta(h) (binding) | GSK3beta(h) --> Cytochrome C(h) (increase of abundance) | E2F-1(m.s.) + GSK3beta(h) <==> E2F-1(m.s.):GSK3beta(h) (binding) | NF-kappaB1(h) + GSK3beta(h) <==> NF-kappaB1(h):GSK3beta(h) (binding) | RelA-p65(h) + GSK3beta(h) <==> RelA-p65(h):GSK3beta(h) (binding) | GSK3beta(h) + NF-kappaB1(m.s.) <==> GSK3beta(h):NF-kappaB1(m.s.) (binding) | GSK3beta(h) + Gemin-4(h) <==> GSK3beta(h):Gemin-4(h) (binding) | HSKM-B(h) + GSK3beta(h) <==> HSKM-B(h):GSK3beta(h) (binding) | GSK3beta(h) + Gemin-3(h) <==> GSK3beta(h):Gemin-3(h) (binding) | GSK3beta(h) + STRAP(h) <==> GSK3beta(h):STRAP(h) (binding) | GSK3beta(h) + GSKIP(h) <==> GSK3beta(h):GSKIP(h) (binding) | GSK3beta(h) + Exportin-6(h) <==> GSK3beta(h):Exportin-6(h) (binding) | GSK3beta(h) + DDX36(h) <==> GSK3beta(h):DDX36(h) (binding) | GSK3beta(h) + RPF2(h) <==> GSK3beta(h):RPF2(h) (binding) | GSK3beta(h) + SMN2(h) <==> GSK3beta(h):SMN2(h) (binding) | GSK3beta(h) + IMP-1(h) <==> GSK3beta(h):IMP-1(h) (binding) | GSK3beta(h) + SF3b1(h) <==> GSK3beta(h):SF3b1(h) (binding) | GSK3beta(h) + U1-70K(h) <==> GSK3beta(h):U1-70K(h) (binding) | GSK3beta(h) + EWS(h) <==> GSK3beta(h):EWS(h) (binding) | GSK3beta(h) + ATP-citrate synthase(h) <==> GSK3beta(h):ATP-citrate synthase(h) (binding) | GSK3beta(h) + beta-catenin(h) <==> GSK3beta(h):beta-catenin(h) (binding) | Smad7(m.s.) + axin(m.s.) + GSK3beta(h) + beta-catenin(h) + apc(h) + CKI(h) <==> Smad7(m.s.):axin(m.s.):GSK3beta(h):beta-catenin(h):apc(h):CKI(h) (binding) | ER-alpha(h) + GSK3beta(h) <==> ER-alpha(h):GSK3beta(h) (binding) | GSK3beta(h) + ATP --> GSK3beta(h){pY216} + ADP (phosphorylation) | GSK3B(h) --> GSK3beta(h) (expression). | Dkk-1(h) --/ GSK3beta(h) (decrease of abundance) | axin(h) + ATP --GSK3beta(h)--> axin(h){p} + ADP (phosphorylation) | beta-catenin(h) + ATP --GSK3beta(h)--> beta-catenin(h){p} + ADP (phosphorylation) | axin(m) + ATP --GSK3beta(h)--> axin(m){p} + ADP (phosphorylation) | APC(x):axin(m) + ATP --GSK3beta(h)--> APC(x){p}:axin(m) + ADP (phosphorylation) | beta-catenin(x) + ATP --GSK3beta(h)--> beta-catenin(x){p} + ADP (phosphorylation) | Tau(h) --GSK3beta(h)--> Tau(h){p} (phosphorylation) | HSF1(h){pS307} + ATP --GSK3beta(h)--> HSF1(h){pS307}{pS303} + ADP (phosphorylation) | apc(h):axin(r) + ATP --GSK3beta(h)--> apc(h){p}:axin(r){p} + ADP (phosphorylation) | axin(h):beta-catenin(h) + ATP --GSK3beta(h)--> axin(h):beta-catenin(h){pS33}{pS37}{pT41}:axin(h) + ADP (phosphorylation) | SNA(h) + ATP --GSK3beta(h)--> SNA(h){pS97}{pS101}{pS}n + ADP (phosphorylation) | RelA-p65(h) + ATP --GSK3beta(h)--> RelA-p65(h){pS468} + ADP (phosphorylation) | Bcl-3(h) + 2 ATP --GSK3beta(h)--> Bcl-3(h){pS394}{pS398} + 2 ADP (phosphorylation) | Bcl-3(h) + ATP --GSK3beta(h)--> Bcl-3(h){p} + ADP (phosphorylation) | Synphilin-1(h) + ATP --GSK3beta(h)--> Synphilin-1(h){p} + ADP (phosphorylation) | CRMP1(h) + ATP --GSK3beta(h)--> CRMP1(h){pT509} + ADP (phosphorylation) | CRMP1(h) + ATP --GSK3beta(h)--> CRMP1(h){pT509} + ADP (phosphorylation) | ER-alpha(h) + ATP --GSK3beta(h)--> ER-alpha(h){pS118} + ADP (phosphorylation) | MEKK4(m.s.) + ATP --GSK3beta(h)--> MEKK4(m.s.){p} + ADP (phosphorylation) | GSK3B(h) --> GSK3beta-1(h) (expression). | GSK3B(h) --> GSK3beta-2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
7 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 9 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 215 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 216 | Phosphotyrosine. | Swiss-Prot 53.0 | 219 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 389 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 390 | Phosphothreonine. | Swiss-Prot 53.0 | 395 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 402 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 43 | Phosphothreonine (MAPK1;MAPK3) | 16039586 | Phospho.ELM 6.0 | 216 | Phosphotyrosine (MAP2K1) | 15020233;17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr3 |
Promoter: 121294703 - 121296703 | Agilent_014791 |
chr3 |
Promoter: 121294703 - 121296703 | GSE27584 |
chr3 |
Promoter: 121294703 - 121296703 | Agilent_014791_44K |
chr3 |
Promoter: 121294703 - 121296703 | Agilent_014791 |
chr3 |
Promoter: 121294703 - 121296703 | PMID:14719065 |