| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3685 |
Name | ITGAV |
Synonym | CD51|MSK8|VNRA|VTNR;integrin, alpha V;ITGAV;integrin, alpha V |
Definition | antigen identified by monoclonal antibody L230|integrin alpha-V|integrin alphaVbeta3|integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)|vitronectin receptor subunit alpha |
Position | 2q31-q32 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 1211 |
TUSON P-value | 0.063258394 |
|
Pathways and Diseases |
|
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | PECAM1 interactions;PID Reactome;500307 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Disease | Drug abuse;FunDO |
Disease | Herpes;FunDO |
Disease | Pleural effusion, Malignant;FunDO |
Disease | IMMUNE;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Cancer;FunDO |
Disease | rheumatoid arthritis;GAD |
Disease | Alzheimer's disease;FunDO |
Disease | Atherosclerosis;FunDO |
|
External Links |
|
Links to Entrez Gene | 3685 |
Links to all GeneRIF Items | 3685 |
Links to iHOP | 3685 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>3685 : length: 3009 atgctcctaggcaccctccttctgatcctgtacatcttaatgttgtgccggatgtttctt ctcgtgggagctcccaaagcaaacaccacccagcctgggattgtggaaggagggcaggtc ctcaaatgtgactggtcttctacccgccggtgccagccaattgaatttgatgcaacaggc aatagagattatgccaaggatgatccattggaatttaagtcccatcagtggtttggagca tctgtgaggtcgaaacaggataaaattttggcctgtgccccattgtaccattggagaact gagatgaaacaggagcgagagcctgttggaacatgctttcttcaagatggaacaaagact gttgagtatgctccatgtagatcacaagatattgatgctgatggacagggattttgtcaa ggaggattcagcattgattttactaaagctgacagagtacttcttggtggtcctggtagc ttttattggcaaggtcagcttatttcggatcaagtggcagaaatcgtatctaaatacgac cccaatgtttacagcatcaagtataataaccaattagcaactcggactgcacaagctatt tttgatgacagctatttgggttattctgtggctgtcggagatttcaatggtgatggcata gatgactttgtttcaggagttccaagagcagcaaggactttgggaatggtttatatttat gatgggaagaacatgtcctccttatacaattttactggcgagcagatggctgcatatttc ggattttctgtagctgccactgacattaatggagatgattatgcagatgtgtttattgga gcacctctcttcatggatcgtggctctgatggcaaactccaagaggtggggcaggtctca gtgtctctacagagagcttcaggagacttccagacgacaaagctgaatggatttgaggtc tttgcacggtttggcagtgccatagctcctttgggagatctggaccaggatggtttcaat gatattgcaattgctgctccatatgggggtgaagataaaaaaggaattgtttatatcttc aatggaagatcaacaggcttgaacgcagtcccatctcaaatccttgaagggcagtgggct gctcgaagcatgccaccaagctttggctattcaatgaaaggagccacagatatagacaaa aatggatatccagacttaattgtaggagcttttggtgtagatcgagctatcttatacagg gccagaccagttatcactgtaaatgctggtcttgaagtgtaccctagcattttaaatcaa gacaataaaacctgctcactgcctggaacagctctcaaagtttcctgttttaatgttagg ttctgcttaaaggcagatggcaaaggagtacttcccaggaaacttaatttccaggtggaa cttcttttggataaactcaagcaaaagggagcaattcgacgagcactgtttctctacagc aggtccccaagtcactccaagaacatgactatttcaagggggggactgatgcagtgtgag gaattgatagcgtatctgcgggatgaatctgaatttagagacaaactcactccaattact atttttatggaatatcggttggattatagaacagctgctgatacaacaggcttgcaaccc attcttaaccagttcacgcctgctaacattagtcgacaggctcacattctacttgactgt ggtgaagacaatgtctgtaaacccaagctggaagtttctgtagatagtgatcaaaagaag atctatattggggatgacaaccctctgacattgattgttaaggctcagaatcaaggagaa ggtgcctacgaagctgagctcatcgtttccattccactgcaggctgatttcatcggggtt gtccgaaacaatgaagccttagcaagactttcctgtgcatttaagacagaaaaccaaact cgccaggtggtatgtgaccttggaaacccaatgaaggctggaactcaactcttagctggt cttcgtttcagtgtgcaccagcagtcagagatggatacttctgtgaaatttgacttacaa atccaaagctcaaatctatttgacaaagtaagcccagttgtatctcacaaagttgatctt gctgttttagctgcagttgagataagaggagtctcgagtcctgatcatatctttcttccg attccaaactgggagcacaaggagaaccctgagactgaagaagatgttgggccagttgtt cagcacatctatgagctgagaaacaatggtccaagttcattcagcaaggcaatgctccat cttcagtggccttacaaatataataataacactctgttgtatatccttcattatgatatt gatggaccaatgaactgcacttcagatatggagatcaaccctttgagaattaagatctca tctttgcaaacaactgaaaagaatgacacggttgccgggcaaggtgagcgggaccatctc atcactaagcgggatcttgccctcagtgaaggagatattcacactttgggttgtggagtt gctcagtgcttgaagattgtctgccaagttgggagattagacagaggaaagagtgcaatc ttgtacgtaaagtcattactgtggactgagacttttatgaataaagaaaatcagaatcat tcctattctctgaagtcgtctgcttcatttaatgtcatagagtttccttataagaatctt ccaattgaggatatcaccaactccacattggttaccactaatgtcacctggggcattcag ccagcgcccatgcctgtgcctgtgtgggtgatcattttagcagttctagcaggattgttg ctactggctgttttggtatttgtaatgtacaggatgggcttttttaaacgggtccggcca cctcaagaagaacaagaaagggagcagcttcaacctcatgaaaatggtgaaggaaactca gaaacttaa |
Protein Sequence |
>3685 : length: 1002 MLLGTLLLILYILMLCRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATG NRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKT VEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYD PNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIY DGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVS VSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF NGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYR ARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVE LLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPIT IFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKK IYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQT RQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDL AVLAAVEIRGVSSPDHIFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLH LQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHL ITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNH SYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLL LLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET |