Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3685

Name

ITGAV

Synonymous

CD51|MSK8|VNRA|VTNR;integrin, alpha V;ITGAV;integrin, alpha V

Definition

antigen identified by monoclonal antibody L230|integrin alpha-V|integrin alphaVbeta3|integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)|vitronectin receptor subunit alpha

Position

2q31-q32

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

CD51(h) + beta6-integrin(h) + LAP3(h) <==> CD51(h):beta6-integrin(h):LAP3(h) (binding)
LAP1(mo) + CD51(h) + beta1-integrin(h) <==> LAP1(mo):CD51(h):beta1-integrin(h) (binding)
LAP1(mo) + CD51(h) + beta5-integrin(h) <==> LAP1(mo):CD51(h):beta5-integrin(h) (binding)
LAP1(mo) + CD51(h) <==> LAP1(mo):CD51(h) (binding)
LAP1(h) + CD51(h) + beta1-integrin(h) <==> LAP1(h):CD51(h):beta1-integrin(h) (binding)
LAP1(h) + CD51(h) + beta3-integrin(h) <==> LAP1(h):CD51(h):beta3-integrin(h) (binding)
LAP1(h) + CD51(h) + beta5-integrin(h) <==> LAP1(h):CD51(h):beta5-integrin(h) (binding)
LAP1(h) + CD51(h) + beta6-integrin(h) <==> LAP1(h):CD51(h):beta6-integrin(h) (binding)
Cas(h) + EGFR(h) + CD51(h) + beta3-integrin(h) + Src(h) <==> Cas(h):EGFR(h):CD51(h):beta3-integrin(h):Src(h) (binding)
CAML1(m.s.) + CD51(h) <==> CAML1(m.s.):CD51(h) (binding)
CD51(h) + aup-1-isoformS(h) <==> CD51(h):aup-1-isoformS(h) (binding)
ITGAV(h) --> CD51(h) (expression).
beta3-integrin(h) + CD51-isoform1(h) <==> beta3-integrin(h):CD51-isoform1(h) (binding)
ITGAV(h) --> CD51-isoform1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

74N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
290N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
296N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
488N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
554N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
615N-linked (GlcNAc...).Swiss-Prot 53.0
704N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
835N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
851N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
874N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
945N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
973N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
980N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 187161545 - 187163545Agilent_014791

chr2

Promoter: 187161545 - 187163545GSE27584

chr2

Promoter: 187161545 - 187163545Agilent_014791_44K


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