| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4216 |
Name | MAP3K4 |
Synonym | MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412;mitogen-activated protein kinase kinase kinase 4;MAP3K4;mitogen-activated protein kinase kinase kinase 4 |
Definition | MAP three kinase 1|MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|MEK kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412 |
Position | 6q26 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 268 |
TUSON P-value | 0.001964233 |
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Pathways and Diseases |
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Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | p38 MAPK signaling pathway;PID Curated;200014 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Oxidative stress response;PANTHER;P00046 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Disease | Embryoma;FunDO |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 4216 |
Links to all GeneRIF Items | 4216 |
Links to iHOP | 4216 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4216 : length: 4827 atgagagaagccgctgccgcgctggtccctcctcccgcctttgccgtcacgcctgccgcc gccatggaggagccgccgccaccgccgccgccgccaccaccgccaccggaacccgagacc gagtcagaacccgagtgctgcttggcggcgaggcaagagggcacattgggagattcagct tgcaagagtcctgaatctgatctagaagacttctccgatgaaacaaatacagagaatctt tatggtacctctccccccagcacacctcgacagatgaaacgcatgtcaaccaaacatcag aggaataatgtggggaggccagccagtcggtctaatttgaaagaaaaaatgaatgcacca aatcagcctccacataaagacactggaaaaacagtggagaatgtggaagaatacagctat aagcaggagaaaaagatccgagcagctcttagaacaacagagcgtgatcataaaaaaaat gtacagtgctcattcatgttagactcagtgggtggatctttgccaaaaaaatcaattcca gatgtggatctcaataagccttacctcagccttggctgtagcaatgctaagcttccagta tctgtgcccatgcctatagccagacctgcacgccagacttctaggactgactgtccagca gatcgtttaaagttttttgaaactttacgacttttgctaaagcttacctcagtctcaaag aaaaaagacagggagcaaagaggacaagaaaatacgtctggtttctggcttaaccgatct aacgaactgatctggttagagctacaagcctggcatgcaggacggacaattaacgaccag gacttctttttatatacagcccgtcaagccatcccagatattattaatgaaatccttact ttcaaagtcgactatgggagcttcgcctttgttagagatagagctggttttaatggtact tcagtagaagggcagtgcaaagccactcctggaacaaagattgtaggttactcaacacat catgagcatctccaacgccagagggtctcatttgagcaggtaaaacggataatggagctg ctagagtacatagaagcactttatccatcattgcaggctcttcagaaggactatgaaaaa tatgctgcaaaagacttccaggacagggtgcaggcactctgtttgtggttaaacatcaca aaagacttaaatcagaaattaaggattatgggcactgttttgggcatcaagaatttatca gacattggctggccagtgtttgaaatcccttcccctcgaccatccaaaggtaatgagccg gagtatgagggtgatgacacagaaggagaattaaaggagttggaaagtagtacggatgag agtgaagaagaacaaatctctgatcctagggtaccggaaatcagacagcccatagataac agcttcgacatccagtcgcgggactgcatatccaagaagcttgagaggctcgaatctgag gatgattctcttggctggggagcaccagactggagcacagaagcaggctttagtagacat tgtctgacttctatttatagaccatttgtagacaaagcactgaagcagatggggttaaga aagttaattttaagacttcacaagctaatggatggttccttgcaaagggcacgtatagca ttggtaaagaacgatcgtccagtggagttttctgaatttccagatcccatgtggggttca gattatgtgcagttgtcaaggacaccaccttcatctgaggagaaatgcagtgctgtgtcg tgggaggagctgaaggccatggatttaccttcattcgaacctgccttcctagttctctgc cgagtccttctgaatgtcatacatgagtgtctgaagttaagattggagcagagacctgct ggagaaccatctctcttgagtattaagcagctggtgagagagtgtaaggaggtcctgaag ggcggcctgctgatgaagcagtactaccagttcatgctgcaggaggttctggaggacttg gagaagcccgactgcaacattgacgcttttgaagaggatctacataaaatgcttatggtg tattttgattacatgagaagctggatccaaatgctacagcaattacctcaagcatcgcat agtttaaaaaatctgttagaagaagaatggaatttcaccaaagaaataactcattacata cggggaggagaagcacaggccgggaagcttttctgtgacattgcaggaatgctgctgaaa tctacaggaagttttttagaatttggcttacaggagagctgtgctgaattttggactagt gcggatgacagcagtgcttccgacgaaatcaggaggtctgttatagagatcagtcgagcc ctgaaggagctcttccatgaagccagagaaagggcttccaaagcacttggatttgctaaa atgttgagaaaggacctggaaatagcagcagaattcaggctttcagccccagttagagac ctcctggatgttctgaaatcaaaacagtatgtcaaggtgcaaattcctgggttagaaaac ttgcaaatgtttgttccagacactcttgctgaggagaagagtattattttgcagttactc aatgcagctgcaggaaaggactgttcaaaagattcagatgacgtactcatcgatgcctat ctgcttctgaccaagcacggtgatcgagcccgtgattcagaggacagctggggcacctgg gaggcacagcctgtcaaagtcgtgcctcaggtggagactgttgacaccctgagaagcatg caggtggataatcttttactagttgtcatgcagtctgcgcatctcacaattcagagaaaa gctttccagcagtccattgagggacttatgactctgtgccaggagcagacatccagtcag ccggtcatcgccaaagctttgcagcagctgaagaatgatgcattggagctatgcaacagg ataagcaatgccattgaccgcgtggaccacatgttcacatcagaatttgatgctgaggtt gatgaatctgaatctgtcaccttgcaacagtactaccgagaagcaatgattcaggggtac aattttggatttgagtatcataaagaagttgttcgtttgatgtctggggagtttagacag aagataggagacaaatatataagctttgcccggaagtggatgaattatgtcctgactaaa tgtgagagtggtagaggtacaagacccaggtgggcgactcaaggatttgattttctacaa gcaattgaacctgcctttatttcagctttaccagaagatgacttcttgagtttacaagcc ttgatgaatgaatgcattggccatgtcataggaaaaccacacagtcctgttacaggtttg taccttgccattcatcggaacagcccccgtcctatgaaggtacctcgatgccatagtgac cctcctaacccacacctcattatccccactccagagggattcagcactcggagcatgcct tccgacgcgcggagccatggcagccctgctgctgctgctgctgctgctgctgctgctgtt gctgccagtcggcccagcccctctggtggtgactctgtgctgcccaaatccatcagcagt gcccatgataccaggggttccagcgttcctgaaaatgatcgattggcttccatagctgct gaattgcagtttaggtccctgagtcgtcactcaagccccacggaggagcgagatgaacca gcatatccaagaggagattcaagtgggtccacaagaagaagttgggaacttcggacacta atcagccagagtaaagatactgcttctaaactaggacccatagaagctatccagaagtca gtccgattgtttgaagaaaagaggtaccgagaaatgaggagaaagaatatcattggtcaa gtttgtgatacgcctaagtcctatgataatgttatgcacgttggcttgaggaaggtgacc ttcaaatggcaaagaggaaacaaaattggagaaggccagtatgggaaggtgtacacctgc atcagcgtcgacaccggggagctgatggccatgaaagagattcgatttcaacctaatgac cataagactatcaaggaaactgcagacgaattgaaaatattcgaaggcatcaaacacccc aatctggttcggtattttggtgtggagctccatagagaagaaatgtacatcttcatggag tactgcgatgaggggactttagaagaggtgtcaaggctgggacttcaggaacatgtgatt aggctgtattcaaagcagatcaccattgcgatcaacgtcctccatgagcatggcatagtc caccgtgacattaaaggtgccaatatcttccttacctcatctggattaatcaaactggga gattttggatgttcagtaaagctcaaaaacaatgcccagaccatgcctggtgaagtgaac agcaccctggggacagcagcatacatggcacctgaagtcatcactcgtgccaaaggagag ggccatgggcgtgcggccgacatctggagtctggggtgtgttgtcatagagatggtgact ggcaagaggccttggcatgagtatgagcacaactttcaaattatgtataaagtggggatg ggacataagccaccaatccctgaaagattaagccctgaaggaaaggacttcctttctcac tgccttgagagtgacccaaagatgagatggaccgccagccagctcctcgaccattcgttt gtcaaggtttgcacagatgaagaatga |
Protein Sequence |
>4216 : length: 1608 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE |