Entrez Gene

Basic Information
Gene ID	4216
Name	MAP3K4
Synonymous	MAPKKK4\|MEKK 4\|MEKK4\|MTK1\|PRO0412;mitogen-activated protein kinase kinase kinase 4;MAP3K4;mitogen-activated protein kinase kinase kinase 4
Definition	MAP three kinase 1\|MAP/ERK kinase kinase 4\|MAPK/ERK kinase kinase 4\|MEK kinase 4\|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of\|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)\|predicted protein of HQ0412
Position	6q26
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
TRAF4(h) + MEKK4(h) <==> TRAF4(h):MEKK4(h) (binding)
annexin-A2(h) + MEKK4(h) <==> annexin-A2(h):MEKK4(h) (binding)
MEKK4(h) + Pyk2(h) <==> MEKK4(h):Pyk2(h) (binding)
MEKK4(h) + ATP --> MEKK4(h){pY} + ADP (phosphorylation)
MEKK4(h) + ATP --Pyk2(h)--> MEKK4(h){pY} + ADP (phosphorylation)
MEKK4(h) + ATP --> MEKK4(h){p} + ADP (phosphorylation; automodification)
MEKK4(h) + SHP-2(h) <==> MEKK4(h):SHP-2(h) (binding)
MAP3K4(h) --> MEKK4(h) (expression).
MEKK4(h){pY} --SHP-2(h)--> p + MEKK4(h) (dephosphorylation)
MKK6(h) + ATP --MEKK4(h)--> MKK6(h){p} + ADP (phosphorylation)
MKK6(m.s.) + ATP --MEKK4(h)--> MKK6(m.s.){p} + ADP (phosphorylation)
MAP3K4(h) --> MEKK4-A(h) (expression).
MAP3K4(h) --> MEKK4-xbb2(h) (expression).
MAP3K4(h) --> MEKK4-B(h) (expression).

Location (AA)	PTM type	Database
Post Transcriptional Modification [Top]
499	Phosphoserine (By similarity).	Swiss-Prot 53.0
1504	Phosphothreonine (By similarity).	Swiss-Prot 53.0