| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4627 |
Name | MYH9 |
Synonym | BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA;myosin, heavy chain 9, non-muscle;MYH9;myosin, heavy chain 9, non-muscle |
Definition | cellular myosin heavy chain, type A|myosin-9|non-muscle myosin heavy chain A|non-muscle myosin heavy chain IIa|non-muscle myosin heavy polypeptide 9|nonmuscle myosin heavy chain II-A |
Position | 22q13.1 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 11017 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Nicotinic acetylcholine receptor signaling pathway;PANTHER;P00044 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Cytoskeletal regulation by Rho GTPase;PANTHER;P00016 |
Disease | Deafness, autosomal dominant 17;OMIM |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | End-stage renal disease (non-diabetic);NHGRI |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Sebastian syndrome;OMIM |
Disease | Thrombocytopenia;FunDO |
Disease | May-Hegglin anomaly;OMIM |
Disease | Macrothrombocytopenia;KEGG DISEASE;H00233 |
Disease | Epstein syndrome;OMIM |
Disease | Deafness;FunDO |
Disease | Fechtner syndrome;OMIM |
Disease | Kidney disease;FunDO |
Disease | Macrothrombocytopenia and progressive sensorineural deafness;OMIM |
Disease | Optic disc size (rim);NHGRI |
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External Links |
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Links to Entrez Gene | 4627 |
Links to all GeneRIF Items | 4627 |
Links to iHOP | 4627 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4627 : length: 5883 atggcacagcaagctgccgataagtatctctatgtggataaaaacttcatcaacaatccg ctggcccaggccgactgggctgccaagaagctggtatgggtgccttccgacaagagtggc tttgagccagccagcctcaaggaggaggtgggcgaagaggccatcgtggagctggtggag aatgggaagaaggtgaaggtgaacaaggatgacatccagaagatgaacccgcccaagttc tccaaggtggaggacatggcagagctcacgtgcctcaacgaagcctcggtgctgcacaac ctcaaggagcgttactactcagggctcatctacacctattcaggcctgttctgtgtggtc atcaatccttacaagaacctgcccatctactctgaagagattgtggaaatgtacaagggc aagaagaggcacgagatgccccctcacatctatgccatcacagacaccgcctacaggagt atgatgcaagaccgagaagatcaatccatcttgtgcactggtgaatctggagctggcaag acggagaacaccaagaaggtcatccagtatctggcgtacgtggcgtcctcgcacaagagc aagaaggaccagggcgagctggagcggcagctgctgcaggccaaccccatcctggaggcc ttcgggaacgccaagaccgtgaagaatgacaactcctcccgcttcggcaaattcattcgc atcaactttgatgtcaatggctacattgttggagccaacattgagacttatcttttggag aaatctcgtgctatccgccaagccaaggaagaacggaccttccacatcttctattatctc ctgtctggggctggagagcacctgaagaccgatctcctgttggagccgtacaacaaatac cgcttcctgtccaatggacacgtcaccatccccgggcagcaggacaaggacatgttccag gagaccatggaggccatgaggattatgggcatcccagaagaggagcaaatgggcctgctg cgggtcatctcaggggttcttcagctcggcaacatcgtcttcaagaaggagcggaacact gaccaggcgtccatgcccgacaacacagctgcccaaaaggtgtcccatctcttgggtatc aatgtgaccgatttcaccagaggaatcctcaccccgcgcatcaaggtgggacgggattac gtccagaaggcgcagactaaagagcaggctgactttgccatcgaggccttggccaaggcg acctatgagcggatgttccgctggctggtgctgcgcatcaacaaggctctggacaagacc aagaggcagggcgcctccttcatcgggatcctggacattgccggcttcgagatctttgat ctgaactcgtttgagcagctgtgcatcaattacaccaatgagaagctgcagcagctcttc aaccacaccatgttcatcctggagcaggaggagtaccagcgcgagggcatcgagtggaac ttcatcgactttggcctcgacctgcagccctgcatcgacctcattgagaagccagcaggc cccccgggcattctggccctgctggacgaggagtgctggttccccaaagccaccgacaag agcttcgtggagaaggtgatgcaggagcagggcacccaccccaagttccagaagcccaag cagctgaaggacaaagctgatttctgcattatccactatgccggcaaggtggattacaaa gctgacgagtggctgatgaagaacatggatcccctgaatgacaacatcgccacactgctc caccagtcctctgacaagtttgtctcggagctgtggaaggatgtggaccgcatcatcggc ctggaccaggtggccggcatgtcggagaccgcactgcccggggccttcaagacgcggaag ggcatgttccgcactgtggggcagctttacaaggagcagctggccaagctgatggctacg ctgaggaacacgaaccccaactttgtccgctgcatcatccccaaccacgagaagaaggcc ggcaagctggacccgcatctcgtgctggaccagctgcgctgcaacggtgttctcgagggc atccgtatctgccgccagggcttccccaacagggtggtcttccaggagtttcggcagaga tatgagatcctgactccaaactccattcccaagggtttcatggacgggaagcaggcgtgc gtgctcatgataaaagccctggagctcgacagcaatctgtaccgcattggccagagcaaa gtcttcttccgtgccggtgtgctggcccacctggaggaggagcgagacctgaagatcacc gacgtcatcatagggttccaggcctgctgcaggggctacctggccaggaaagcatttgcc aagcggcagcagcagcttaccgccatgaaggtcctccagcggaactgcgctgcctacctg aagctgcggaactggcagtggtggcggctcttcaccaaggtcaagccgctgctgcaggtg agccggcaggaggaggagatgatggccaaggaggaggagctggtgaaggtcagagagaag cagctggctgcggagaacaggctcacggagatggagacgctgcagtctcagctcatggca gagaaattgcagctgcaggagcagctccaggcagaaaccgagctgtgtgccgaggctgag gagctccgggcccgcctgaccgccaagaagcaggaattagaagagatctgccatgaccta gaggccagggtggaggaggaggaggagcgctgccagcacctgcaggcggagaagaagaag atgcagcagaacatccaggagcttgaggagcagctggaggaggaggagagcgcccggcag aagctgcagctggagaaggtgaccaccgaggcgaagctgaaaaagctggaggaggagcag atcatcctggaggaccagaactgcaagctggccaaggaaaagaaactgctggaagacaga atagctgagttcaccaccaacctcacagaagaggaggagaaatctaagagcctcgccaag ctcaagaacaagcatgaggcaatgatcactgacttggaagagcgcctccgcagggaggag aagcagcgacaggagctggagaagacccgccggaagctggagggagactccacagacctc agcgaccagatcgccgagctccaggcccagatcgcggagctcaagatgcagctggccaag aaagaggaggagctccaggccgccctggccagagtggaagaggaagctgcccagaagaac atggccctcaagaagatccgggagctggaatctcagatctctgaactccaggaagacctg gagtctgagcgtgcttccaggaataaagctgagaagcagaaacgggaccttggggaagag ctagaggctctgaaaacagagttggaggacacgctggattccacagctgcccagcaggag ctcaggtcaaaacgtgagcaggaggtgaacatcctgaagaagaccctggaggaggaggcc aagacccacgaggcccagatccaggagatgaggcagaagcactcacaggccgtggaggag ctggcggagcagctggagcagacgaagcgggtgaaagcaaacctcgagaaggcaaagcag actctggagaacgagcggggggagctggccaacgaggtgaaggtgctgctgcagggcaaa ggggactcggagcacaagcgcaagaaagtggaggcgcagctgcaggagctgcaggtcaag ttcaacgagggagagcgcgtgcgcacagagctggccgacaaggtcaccaagctgcaggtg gagctggacaacgtgaccgggcttctcagccagtccgacagcaagtccagcaagctcacc aaggacttctccgcgctggagtcccagctgcaggacactcaggagctgctgcaggaggag aaccggcagaagctgagcctgagcaccaagctcaagcaggtggaggacgagaagaattcc ttccgggagcagctggaggaggaggaggaggccaagcacaacctggagaagcagatcgcc accctccatgcccaggtggccgacatgaaaaagaagatggaggacagtgtggggtgcctg gaaactgctgaggaggtgaagaggaagctccagaaggacctggagggcctgagccagcgg cacgaggagaaggtggccgcctacgacaagctggagaagaccaagacgcggctgcagcag gagctggacgacctgctggtggacctggaccaccagcgccagagcgcgtgcaacctggag aagaagcagaagaagtttgaccagctcctggcggaggagaagaccatctctgccaagtat gcagaggagcgcgaccgggctgaggcggaggcccgagagaaggagaccaaggctctgtcg ctggcccgggccctggaggaagccatggagcagaaggcggagctggagcggctcaacaag cagttccgcacggagatggaggaccttatgagctccaaggatgatgtgggcaagagtgtc cacgagctggagaagtccaagcgggccctagagcagcaggtggaggagatgaagacgcag ctggaagagctggaggacgagctgcaggccaccgaagatgccaagctgcggttggaggtc aacctgcaggccatgaaggcccagttcgagcgggacctgcagggccgggacgagcagagc gaggagaagaagaagcagctggtcagacaggtgcgggagatggaggcagagctggaggac gagaggaagcagcgctcgatggcagtggccgcccggaagaagctggagatggacctgaag gacctggaggcgcacatcgactcggccaacaagaaccgggacgaagccatcaaacagctg cggaagctgcaggcccagatgaaggactgcatgcgcgagctggatgacacccgcgcctct cgtgaggagatcctggcccaggccaaagagaacgagaagaagctgaagagcatggaggcc gagatgatccagttgcaggaggaactggcagccgcggagcgtgccaagcgccaggcccag caggagcgggatgagctggctgacgagatcgccaacagcagcggcaaaggagccctggcg ttagaggagaagcggcgtctggaggcccgcatcgcccagctggaggaggagctggaggag gagcagggcaacacggagctgatcaacgaccggctgaagaaggccaacctgcagatcgac cagatcaacaccgacctgaacctggagcgcagccacgcccagaagaacgagaatgctcgg cagcagctggaacgccagaacaaggagcttaaggtcaagctgcaggagatggagggcact gtcaagtccaagtacaaggcctccatcaccgccctcgaggccaagattgcacagctggag gagcagctggacaacgagaccaaggagcgccaggcagcctgcaaacaggtgcgtcggacc gagaagaagctgaaggatgtgctgctgcaggtggatgacgagcggaggaacgccgagcag tacaaggaccaggccgacaaggcatctacccgcctgaagcagctcaagcggcagctggag gaggccgaagaggaggcccagcgggccaacgcctcccgccggaaactgcagcgcgagctg gaggacgccactgagacggccgatgccatgaaccgcgaagtcagctccctaaagaacaag ctcaggcgcggggacctgccgtttgtcgtgccccgccgaatggcccggaaaggcgccggg gatggctccgacgaagaggtagatggcaaagcggatggggctgaggccaaacctgccgaa taa |
Protein Sequence |
>4627 : length: 1960 MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVE NGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVV INPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGK TENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIR INFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKY RFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNT DQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKA TYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLF NHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDK SFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLL HQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMAT LRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQR YEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKIT DVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQV SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQ YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK LRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE |