| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4734 |
Name | NEDD4 |
Synonym | NEDD4-1|RPF1;neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase;NEDD4;neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase NEDD4|cell proliferation-inducing gene 53 protein|neural precursor cell expressed developmentally down-regulated protein 4|receptor-potentiating factor 1 |
Position | 15q |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 11272 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Disease | CANCER;GAD |
Disease | Chronic lymphocytic leukemia;NHGRI |
Disease | Keloid;NHGRI |
Disease | Chronic lymphocytic leukemia;GAD |
|
External Links |
|
Links to Entrez Gene | 4734 |
Links to all GeneRIF Items | 4734 |
Links to iHOP | 4734 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4734 : length: 2703 atggcaacttgcgcggtggaggtgttcgggctcctggaggacgaggaaaattcacgaatt gtgagagtaagagttatagccggaataggccttgccaagaaggatatattgggagctagt gatccttacgtgagagtgacgttatatgacccaatgaatggagttcttacaagtgtgcaa acaaaaaccattaaaaagagtttgaatccaaagtggaatgaagaaatattattcagagtt catcctcagcagcaccggcttctttttgaagtgtttgacgaaaaccgattgacaagagat gatttcctaggtcaagtggatgttccactttatccattaccgacagaaaatccaagattg gagagaccatatacatttaaggattttgttcttcatccaagaagtcacaaatcaagagtt aaaggttatctgagactaaaaatgacttatttacctaaaaccagtggctcagaagatgat aatgcagaacaggctgaggaattagagcctggctgggttgttttggaccaaccagatgct gcttgccatttgcagcaacaacaagaaccttctcctctacctccagggtgggaagagagg caggatatccttggaaggacctattatgtaaaccatgaatctagaagaacacagtggaaa agaccaacccctcaggacaacctaacagatgctgagaatggcaacattcaactgcaagca caacgtgcatttaccaccaggcggcagatatccgaggaaacagaaagtgttgacaaccga gagtcttccgagaactgggaaattataagagaagatgaagccaccatgtatagcaaccag gccttcccatcacctccaccgtcaagtaacttggatgttccaactcatcttgcagaagaa ttgaatgccagactcaccatttttggaaattcagccgtgagccagccagcatcgagctca aatcattccagcagaagaggcagcttacaagcctatacttttgaggaacaacctacactt cctgtgcttttgcctacttcatctggattaccaccaggttgggaagaaaaacaagatgaa agaggaagatcatattatgtagatcacaattccagaacgactacttggacaaagcccact gtacaggccacagtggagaccagtcagctgacctcaagccagagttctgcaggccctcaa tcacaagcctccaccagtgattcaggccagcaggtgacccagccatctgaaattgagcaa ggattccttcctaaaggctgggaagtccggcatgcaccaaatgggaggcctttctttatt gaccacaacactaaaaccaccacctgggaagatccaagattgaaaattccagcccatctg agaggaaagacatcacttgatacttccaatgatctagggcctttacctccaggatgggaa gagagaactcacacagatggaagaatcttctacataaatcacaatataaaaagaacacaa tgggaagatcctcggttggagaatgtagcaataactggaccagcagtgccctactccagg gattacaaaagaaagtatgagttcttccgaagaaagttgaagaagcagaatgacattcca aacaaatttgaaatgaaacttcgccgagcaactgttcttgaagactcttaccggagaatt atgggtgtcaagagagcagacttcctgaaggctcgactgtggattgagtttgatggtgaa aagggattggattatggaggagttgccagagaatggttcttcctgatctcaaaggaaatg tttaacccttattatgggttgtttgaatattctgctacggacaattataccctacagata aatccaaactctggattgtgtaacgaagatcacctctcttacttcaagtttattggtcgg gtagctggaatggcagtttatcatggcaaactgttggatggttttttcatccgcccattt tacaagatgatgcttcacaaaccaataacccttcatgatatggaatctgtggatagtgaa tattacaattccctaagatggattcttgaaaatgacccaacagaattggacctcaggttt atcatagatgaagaactttttggacagacacatcaacatgagctgaaaaatggtggatca gaaatagttgtcaccaataagaacaaaaaggaatatatttatcttgtaatacaatggcga tttgtaaaccgaatccagaagcaaatggctgcttttaaagagggattctttgaactaata ccacaggatctcatcaaaatttttgatgaaaatgaactagagcttcttatgtgtggactg ggagatgttgatgtgaatgactggagggaacatacaaagtataaaaatggctacagtgca aatcatcaggttatacagtggttttggaaggctgttttaatgatggattcagaaaaaaga ataagattacttcagtttgtcactggcacatctcgggtgcctatgaatggatttgctgaa ctatacggttcaaatggaccacagtcatttacagttgaacagtggggtactcctgaaaag ctgccaagagctcatacctgttttaatcgcctggacttgccaccttatgaatcatttgaa gaattatgggataaacttcagatggcaattgaaaacacccagggctttgatggagttgat tag |
Protein Sequence |
>4734 : length: 900 MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQ TKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRL ERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDA ACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQA QRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEE LNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDE RGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQ GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWE ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIP NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGS EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD |