| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 4790 |
Name | NFKB1 |
Synonym | EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1;NFKB1;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Definition | DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit |
Position | 4q24 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 11326 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha;PID Curated;200133 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Regulated proteolysis of p75NTR;PID Reactome;500620 |
Pathway | Downstream TCR signaling;PID Reactome;500482 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | Alternative NF-kappaB pathway;PID Curated;200037 |
Pathway | NF-kB is activated and signals survival;PID Reactome;500615 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | Signaling events mediated by HDAC Class I;PID Curated;200070 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | inflammatory bowel disease;GAD |
Disease | diabetes, type 1;GAD |
Disease | IMMUNE;GAD |
Disease | sarcoidosis;GAD |
Disease | CANCER;GAD |
Disease | melanoma;GAD |
Disease | Arthritis, Psoriatic;GAD |
Disease | Multiple Myeloma;GAD |
Disease | ulcerative colitis;GAD |
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External Links |
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Links to Entrez Gene | 4790 |
Links to all GeneRIF Items | 4790 |
Links to iHOP | 4790 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4790 : length: 2907 atggcagaagatgatccatatttgggaaggcctgaacaaatgtttcatttggatccttct ttgactcatacaatatttaatccagaagtatttcaaccacagatggcactgccaacagat ggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgta tgtgaaggcccatcccatggtggactacctggtgcctctagtgaaaagaacaagaagtct taccctcaggtcaaaatctgcaactatgtgggaccagcaaaggttattgttcagttggtc acaaatggaaaaaatatccacctgcatgcccacagcctggtgggaaaacactgtgaggat gggatctgcactgtaactgctggacccaaggacatggtggtcggcttcgcaaacctgggt atacttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcg tgtataaggggctataatcctggactcttggtgcaccctgaccttgcctatttgcaagca gaaggtggaggggaccggcagctgggagatcgggaaaaagagctaatccgccaagcagct ctgcagcagaccaaggagatggacctcagcgtggtgcggctcatgtttacagcttttctt ccggatagcactggcagcttcacaaggcgcctggaacccgtggtatcagacgccatctat gacagtaaagcccccaatgcatccaacttgaaaattgtaagaatggacaggacagctgga tgtgtgactggaggggaggaaatttatcttctttgtgacaaagttcagaaagatgacatc cagattcgattttatgaagaggaagaaaatggtggagtctgggaaggatttggagatttt tcccccacagatgttcatagacaatttgccattgtcttcaaaactccaaagtataaagat attaatattacaaaaccagcctctgtgtttgtccagcttcggaggaaatctgacttggaa actagtgaaccaaaacctttcctctactatcctgaaatcaaagataaagaagaagtgcag aggaaacgtcagaagctcatgcccaatttttcggatagtttcggcggtggtagtggtgct ggagctggaggcggaggcatgtttggtagtggcggtggaggagggggcactggaagtaca ggtccagggtatagcttcccacactatggatttcctacttatggtgggattactttccat cctggaactactaaatctaatgctgggatgaagcatggaaccatggacactgaatctaaa aaggaccctgaaggttgtgacaaaagtgatgacaaaaacactgtaaacctctttgggaaa gttattgaaaccacagagcaagatcaggagcccagcgaggccaccgttgggaatggtgag gtcactctaacgtatgcaacaggaacaaaagaagagagtgctggagttcaggataacctc tttctagagaaggctatgcagcttgcaaagaggcatgccaatgcccttttcgactacgcg gtgacaggagacgtgaagatgctgctggccgtccagcgccatctcactgctgtgcaggat gagaatggggacagtgtcttacacttagcaatcatccaccttcattctcaacttgtgagg gatctactagaagtcacatctggtttgatttctgatgacattatcaacatgagaaatgat ctgtaccagacgcccttgcacttggcagtgatcactaagcaggaagatgtggtggaggat ttgctgagggctggggccgacctgagccttctggaccgcttgggtaactctgttttgcac ctagctgccaaagaaggacatgataaagttctcagtatcttactcaagcacaaaaaggca gcactacttcttgaccaccccaacggggacggtctgaatgccattcatctagccatgatg agcaatagcctgccatgtttgctgctgctggtggccgctggggctgacgtcaatgctcag gagcagaagtccgggcgcacagcactgcacctggctgtggagcacgacaacatctcattg gcaggctgcctgctcctggagggtgatgcccatgtggacagtactacctacgatggaacc acacccctgcatatagcagctgggagagggtccaccaggctggcagctcttctcaaagca gcaggagcagatcccctggtggagaactttgagcctctctatgacctggatgactcttgg gaaaatgcaggagaggatgaaggagttgtgcctggaaccacgcctctagatatggccacc agctggcaggtatttgacatattaaatgggaaaccatatgagccagagtttacatctgat gatttactagcacaaggagacatgaaacagctggctgaagatgtgaagctgcagctgtat aagttactagaaattcctgatccagacaaaaactgggctactctggcgcagaaattaggt ctggggatacttaataatgccttccggctgagtcctgctccttccaaaacacttatggac aactatgaggtctctgggggtacagtcagagagctggtggaggccctgagacaaatgggc tacaccgaagcaattgaagtgatccaggcagcctccagcccagtgaagaccacctctcag gcccactcgctgcctctctcgcctgcctccacaaggcagcaaatagacgagctccgagac agtgacagtgtctgcgacagcggcgtggagacatccttccgcaaactcagctttaccgag tctctgaccagtggtgcctcactgctaactctcaacaaaatgccccatgattatgggcag gaaggacctctagaaggcaaaatttag |
Protein Sequence |
>4790 : length: 968 MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ EGPLEGKI |