| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 4790 |
Name | NFKB1 |
Synonymous | EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1;NFKB1;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Definition | DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit |
Position | 4q24 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
NF-kappaB1(h) + ATP --IKK-beta(h)--> NF-kappaB1(h){p} + ADP (phosphorylation) | c-Rel(h) + NF-kappaB1(h) <==> c-Rel(h):NF-kappaB1(h) (binding). | c-Rel(m) + NF-kappaB1(h) <==> c-Rel(m):NF-kappaB1(h) (binding). | NF-kappaB1(h) + IkappaB-beta(h) <==> NF-kappaB1(h):IkappaB-beta(h) (binding). | IkappaB-beta(c) + NF-kappaB1(h) <==> IkappaB-beta(c):NF-kappaB1(h) (binding). | NF-kappaB1(h) + NF-kappaB1-p50(h) <==> NF-kappaB1-p50(h):NF-kappaB1(h) (binding). | v-Rel(REVT) + NF-kappaB1(h) <==> v-Rel(REVT):NF-kappaB1(h) (binding). | NF-kappaB1(h) + IkappaB-alpha(h) <==> NF-kappaB1(h):IkappaB-alpha(h) (binding). | IkappaB-beta(m) + NF-kappaB1(h) <==> IkappaB-beta(m):NF-kappaB1(h) (binding). | c-Rel(c) + NF-kappaB1(h) <==> c-Rel(c):NF-kappaB1(h) (binding). | Cot(h) + NF-kappaB1(h) <==> Cot(h):NF-kappaB1(h) (binding) | NF-kappaB1(h) + ATP --CSN(h)--> NF-kappaB1(h){p} + ADP (phosphorylation) | NF-kappaB1(h) --> NF-kappaB1-p50(h) (processing) | NF-kappaB1(h) + PARP(h) <==> NF-kappaB1(h):PARP(h) (binding) | IkappaB-alpha(h) + NF-kappaB1(h) + RelA-p65(h) + rps3(h) <==> IkappaB-alpha(h):NF-kappaB1(h):RelA-p65(h):rps3(h) (binding) | rps3(h) + RelA-p65(h) + NF-kappaB1(h) <==> rps3(h):RelA-p65(h):NF-kappaB1(h) (binding) | NF-kappaB1(h) + 2 ATP --> NF-kappaB1(h){pS927}{pS932} + 2 ADP (phosphorylation) | NF-kappaB1(h) + GSK3beta(h) <==> NF-kappaB1(h):GSK3beta(h) (binding) | RelA-p65(h) + NF-kappaB1(h) <==> RelA-p65(h):NF-kappaB1(h) (binding) | NF-kappaB1(h) --> NF-kappaB1(h) (translocation) | NF-kappaB1(h) --> Ig-kappa(m) (DNA binding). | NF-kappaB1(h) --> Irf1(m) (DNA binding). | NF-kappaB1(h) --> Irf8(m) (DNA binding). | NF-kappaB1(h) --> DEFB4(h) (DNA binding). | NF-kappaB1(h) --> IL8(h) (DNA binding). | NF-kappaB1(h) --> IL28B(h) (DNA binding). | NF-kappaB1(h) --> IL29(h) (DNA binding). | NFKB1(h) --> NF-kappaB1(h) (expression). | TNF-alpha(h) --/ NF-kappaB1(h) (decrease of abundance) | Murr1(h) --/ NF-kappaB1(h) (decrease of abundance) | IL-17A(h) --> NF-kappaB1(h) (increase of abundance) | NF-kappaB1(h) --> NF-kappaB1(h) (translocation) | IFNalpha(m.s.) --> NF-kappaB1(h) (increase of abundance) | Jagged1(h) --> NF-kappaB1(h) (increase of abundance) | NF-kappaB1-isoform1(h) + ATP --IKK-beta(m.s.)--> ADP + NF-kappaB1-isoform1(h){p} (phosphorylation) | NF-kappaB1-isoform1(h) --> p50(h) (processing) | NF-kappaB1-isoform1(h) --> p50(h) + protein remnants (degradation) | NF-kappaB1-isoform1(h) + Bcl-3(h) <==> NF-kappaB1-isoform1(h):Bcl-3(h) (binding) | NF-kappaB1-isoform1(h) + GR(h) <==> NF-kappaB1-isoform1(h):GR(h) (binding) | NF-kappaB1-isoform1(h) --> p50(h) + protein remnants (processing) | NF-kappaB1-isoform1(h) --> protein remnants (degradation) | NF-kappaB1-isoform1(h) + ATP --> NF-kappaB1-isoform1(h){pS927} + ADP (phosphorylation) | NF-kappaB1-isoform1(h) + ATP --> NF-kappaB1-isoform1(h){pS932} + ADP (phosphorylation) | NF-kappaB1-isoform1(h) + n ubiquitin(h) --> NF-kappaB1-isoform1(h){ub}n (ubiquitination) | beta-TrCP1(m.s.) + NF-kappaB1-isoform1(h) <==> beta-TrCP1(m.s.):NF-kappaB1-isoform1(h) (binding) | HOS(m.s.) + NF-kappaB1-isoform1(h) <==> HOS(m.s.):NF-kappaB1-isoform1(h) (binding) | NFKB1(h) --> NF-kappaB1-isoform1(h) (expression). | IKK-beta(m.s.) --> NF-kappaB1-isoform1(h) (increase of processing) | IGFBP-2(h) --> NF-kappaB1-isoform1(h) (increase of abundance) | NF-kappaB1-isoform2(h) + ATP --Cot(h){p}--> NF-kappaB1-isoform2(h){p} + ADP (phosphorylation) | NF-kappaB1-isoform2(h) + Cot(h) <==> NF-kappaB1-isoform2(h):Cot(h) (binding) | NF-kappaB1-isoform2(h) + ATP --> NF-kappaB1-isoform2(h){pS933} + ADP (phosphorylation) | NFKB1(h) --> NF-kappaB1-isoform2(h) (expression). | NFKB1(h) --> NF-KB1(h) (expression). | hsa-miR-9 --/ NF-KB1(h) (increase of mRNA decay). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
337 | Phosphoserine (by PKA) (Potential). | Swiss-Prot 53.0 | 927 | Phosphoserine (Probable). | Swiss-Prot 53.0 | 923 | Phosphoserine (IKK-beta;IKK) | 11158290;10469655 | Phospho.ELM 6.0 | 893 | Phosphoserine | 8522173 | Phospho.ELM 6.0 | 903 | Phosphoserine (GSK-3beta) | 12871932 | Phospho.ELM 6.0 | 907 | Phosphoserine (GSK-3beta) | 12871932 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr4 |
Promoter: 103640018 - 103642018 | Agilent_014791 |
chr4 |
Promoter: 103640018 - 103642018 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 103640018 - 103642018 | GSE27584 |
chr4 |
Promoter: 103640018 - 103642018 | Agilent_014791_44K |