| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4853 |
Name | NOTCH2 |
Synonym | AGS2|HJCYS|hN2;notch 2;NOTCH2;notch 2 |
Definition | Notch homolog 2|neurogenic locus notch homolog protein 2 |
Position | 1p13-p11 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 72 |
TUSON P-value | 2.76E-07 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | Notch signaling pathway;PANTHER;P00045 |
Pathway | Transport of Notch receptor precursor to golgi;PID Reactome;500111 |
Pathway | Mature Notch receptor trafficks to plasma membrane;PID Reactome;500113 |
Pathway | Signaling by Notch;PID Reactome;500110 |
Pathway | Notch receptor binds with a ligand;PID Reactome;500114 |
Pathway | A third proteolytic cleavage releases NICD;PID Reactome;500116 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Notch signaling pathway;KEGG PATHWAY;hsa04330 |
Pathway | NICD trafficks to nucleus;PID Reactome;500117 |
Pathway | Gene Expression;Reactome;REACT:71 |
Pathway | Signaling by Notch;Reactome;REACT:299 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Notch signaling pathway;PID Curated;200013 |
Pathway | Maturation of Notch precursor via proteolytic cleavage;PID Reactome;500112 |
Pathway | Dorso-ventral axis formation;KEGG PATHWAY;hsa04320 |
Pathway | Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor;PID Reactome;500115 |
Disease | Type 2 diabetes;NHGRI |
Disease | diabetes, type 2;GAD |
Disease | Metabolic diseases;KEGG DISEASE |
Disease | METABOLIC;GAD |
Disease | Type II diabetes mellitus;KEGG DISEASE;H00409 |
Disease | Alagille syndrome 2;OMIM |
Disease | Diabetes;KEGG DISEASE |
Disease | type 2 diabetes;GAD |
|
External Links |
|
Links to Entrez Gene | 4853 |
Links to all GeneRIF Items | 4853 |
Links to iHOP | 4853 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4853 : length: 3708 atgcccgccctgcgccccgctctgctgtgggcgctgctggcgctctggctgtgctgcgcg gcccccgcgcatgcattgcagtgtcgagatggctatgaaccctgtgtaaatgaaggaatg tgtgttacctaccacaatggcacaggatactgcaaatgtccagaaggcttcttgggggaa tattgtcaacatcgagacccctgtgagaagaaccgctgccagaatggtgggacttgtgtg gcccaggccatgctggggaaagccacgtgccgatgtgcctcagggtttacaggagaggac tgccagtactcaacatctcatccatgctttgtgtctcgaccctgcctgaatggcggcaca tgccatatgctcagccgggatacctatgagtgcacctgtcaagtcgggtttacaggtaag gagtgccaatggacggatgcctgcctgtctcatccctgtgcaaatggaagtacctgtacc actgtggccaaccagttctcctgcaaatgcctcacaggcttcacagggcagaaatgtgag actgatgtcaatgagtgtgacattccaggacactgccagcatggtggcacctgcctcaac ctgcctggttcctaccagtgccagtgccctcagggcttcacaggccagtactgtgacagc ctgtatgtgccctgtgcaccctcaccttgtgtcaatggaggcacctgtcggcagactggt gacttcacttttgagtgcaactgccttccaggttttgaagggagcacctgtgagaggaat attgatgactgccctaaccacaggtgtcagaatggaggggtttgtgtggatggggtcaac acttacaactgccgctgtcccccacaatggacaggacagttctgcacagaggatgtggat gaatgcctgctgcagcccaatgcctgtcaaaatgggggcacctgtgccaaccgcaatgga ggctatggctgtgtatgtgtcaacggctggagtggagatgactgcagtgagaacattgat gattgtgccttcgcctcctgtactccaggctccacctgcatcgaccgtgtggcctccttc tcttgcatgtgcccagaggggaaggcaggtctcctgtgtcatctggatgatgcatgcatc agcaatccttgccacaagggggcactgtgtgacaccaaccccctaaatgggcaatatatt tgcacctgcccacaaggctacaaaggggctgactgcacagaagatgtggatgaatgtgcc atggccaatagcaatccttgtgagcatgcaggaaaatgtgtgaacacggatggcgccttc cactgtgagtgtctgaagggttatgcaggacctcgttgtgagatggacatcaatgagtgc cattcagacccctgccagaatgatgctacctgtctggataagattggaggcttcacatgt ctgtgcatgccaggtttcaaaggtgtgcattgtgaattagaaataaatgaatgtcagagc aacccttgtgtgaacaatgggcagtgtgtggataaagtcaatcgtttccagtgcctgtgt cctcctggtttcactgggccagtttgccagattgatattgatgactgttccagtactccg tgtctgaatggggcaaagtgtatcgatcacccgaatggctatgaatgccagtgtgccaca ggtttcactggtgtgttgtgtgaggagaacattgacaactgtgaccccgatccttgccac catggtcagtgtcaggatggtattgattcctacacctgcatctgcaatcccgggtacatg ggcgccatctgcagtgaccagattgatgaatgttacagcagcccttgcctgaacgatggt cgctgcattgacctggtcaatggctaccagtgcaactgccagccaggcacgtcaggggtt aattgtgaaattaattttgatgactgtgcaagtaacccttgtatccatggaatctgtatg gatggcattaatcgctacagttgtgtctgctcaccaggattcacagggcagagatgtaac attgacattgatgagtgtgcctccaatccctgtcgcaagggtgcaacatgtatcaacggt gtgaatggtttccgctgtatatgccccgagggaccccatcaccccagctgctactcacag gtgaacgaatgcctgagcaatccctgcatccatggaaactgtactggaggtctcagtgga tataagtgtctctgtgatgcaggctgggttggcatcaactgtgaagtggacaaaaatgaa tgcctttcgaatccatgccagaatggaggaacttgtgacaatctggtgaatggatacagg tgtacttgcaagaagggctttaaaggctataactgccaggtgaatattgatgaatgtgcc tcaaatccatgcctgaaccaaggaacctgctttgatgacataagtggctacacttgccac tgtgtgctgccatacacaggcaagaattgtcagacagtattggctccctgttccccaaac ccttgtgagaatgctgctgtttgcaaagagtcaccaaattttgagagttatacttgcttg tgtgctcctggctggcaaggtcagcggtgtaccattgacattgacgagtgtatctccaag ccctgcatgaaccatggtctctgccataacacccagggcagctacatgtgtgaatgtcca ccaggcttcagtggtatggactgtgaggaggacattgatgactgccttgccaatccttgc cagaatggaggttcctgtatggatggagtgaatactttctcctgcctctgccttccgggt ttcactggggataagtgccagacagacatgaatgagtgtctgagtgaaccctgtaagaat ggagggacctgctctgactacgtcaacagttacacttgcaagtgccaggcaggatttgat ggagtccattgtgagaacaacatcaatgagtgcactgagagctcctgtttcaatggtggc acatgtgttgatgggattaactccttctcttgcttgtgccctgtgggtttcactggatcc ttctgcctccatgagatcaatgaatgcagctctcatccatgcctgaatgagggaacgtgt gttgatggcctgggtacctaccgctgcagctgccccctgggctacactgggaaaaactgt cagaccctggtgaatctctgcagtcggtctccatgtaaaaacaaaggtacttgcgttcag aaaaaagcagagtcccagtgcctatgtccatctggatgggctggtgcctattgtgacgtg cccaatgtctcttgtgacatagcagcctccaggagaggtgtgcttgttgaacacttgtgc cagcactcaggtgtctgcatcaatgctggcaacacgcattactgtcagtgccccctgggc tatactgggagctactgtgaggagcaactcgatgagtgtgcgtccaacccctgccagcac ggggcaacatgcagtgacttcattggtggatacagatgcgagtgtgtcccaggctatcag ggtgtcaactgtgagtatgaagtggatgagtgccagaatcagccctgccagaatggaggc acctgtattgaccttgtgaaccatttcaagtgctcttgcccaccaggcactcggggtatg aaatcatccttatccattttccatccagggcattgtcttaagttataa |
Protein Sequence |
>4853 : length: 1235 MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE YCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGT CHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTG DFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC LCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICM DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYR CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPN PCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECP PGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKN GGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGS FCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQ KKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLG YTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGG TCIDLVNHFKCSCPPGTRGMKSSLSIFHPGHCLKL |