| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4853 |
Name | NOTCH2 |
Synonymous | AGS2|HJCYS|hN2;notch 2;NOTCH2;notch 2 |
Definition | Notch homolog 2|neurogenic locus notch homolog protein 2 |
Position | 1p13-p11 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
Notch2(h) --> Notch2TM(h) + Notch2EC(h) (cleavage) | Notch2(h) --PACE(h)--> Notch2EC(h) + Notch2TM(h) (cleavage) | NOTCH2(h) --> Notch2(h) (expression). | MEF2C(m) + Notch2(h) <==> MEF2C(m):Notch2(h) (binding) | NOTCH2(h) --> Notch2(h) (expression). | NOTCH2(h) --> NOTCH2(h) (expression). | hsa-miR-34a --/ NOTCH2(h) (translational repression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
46 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 155 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 733 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1102 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1465 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1808 | Phosphothreonine. | Swiss-Prot 53.0 | 1841 | Phosphoserine. | Swiss-Prot 53.0 | 1842 | Phosphoserine. | Swiss-Prot 53.0 | 1845 | Phosphoserine. | Swiss-Prot 53.0 | 2070 | Phosphoserine. | Swiss-Prot 53.0 | 2078 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1808 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 2070 | Phosphoserine | 15302935 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr1 |
Promoter: 120413299 - 120415299 | GoldenGate_Methylation_Cancer_Panel_I |
chr1 |
Promoter: 120413299 - 120415299 | Agilent_014791_44K |
chr1 |
Promoter: 120413299 - 120415299 | E-GEOD-20553 |