| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4869 |
Name | NPM1 |
Synonym | B23|NPM;nucleophosmin (nucleolar phosphoprotein B23, numatrin);NPM1;nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
Definition | nucleolar protein NO38|nucleophosmin|nucleophosmin/nucleoplasmin family, member 1 |
Position | 5q35.1 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 17 |
TUSON P-value | 1.48E-31 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | Deposition of New CENPA-containing Nucleosomes at the Centromere;PID Reactome;500664 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | Chromosome Maintenance;Reactome;REACT:22172 |
Pathway | Aurora B signaling;PID Curated;200010 |
Pathway | HIV Infection;Reactome;REACT:6185 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Disease | CANCER;GAD |
Disease | leukemia, myeloid;GAD |
Disease | Leukemia, acute myeloid;OMIM |
Disease | Leukemia, acute promyelocytic, NPM/RARA type;OMIM |
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External Links |
|
Links to Entrez Gene | 4869 |
Links to all GeneRIF Items | 4869 |
Links to iHOP | 4869 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4869 : length: 780 atggaagattcgatggacatggacatgagccccctgaggccccagaactatcttttcggt tgtgaactaaaggccgacaaagattatcactttaaggtggataatgatgaaaatgagcac cagttatctttaagaacggtcagtttaggggctggtgcaaaggatgagttgcacattgtt gaagcagaggcaatgaattacgaaggcagtccaattaaagtaacactggcaactttgaaa atgtctgtacagccaacggtttcccttgggggctttgaaataacaccaccagtggtctta aggttgaagtgtggttcagggccagtgcatattagtggacagcacttagtagctgtggag gaagatgcagagtcagaagatgaagaggaggaggatgtgaaactcttaagtatatctgga aagcggtctgcccctggaggtggtagcaaggttccacagaaaaaagtaaaacttgctgct gatgaagatgatgacgatgatgatgaagaggatgatgatgaagatgatgatgatgatgat tttgatgatgaggaagctgaagaaaaagcgccagtgaagaaatctatacgagatactcca gccaaaaatgcacaaaagtcaaatcagaatggaaaagactcaaaaccatcatcaacacca agatcaaaaggacaagaatccttcaagaaacaggaaaaaactcctaaaacaccaaaagga cctagttctgtagaagacattaaagcaaaaatgcaagcaagtatagaaaaagcgcattga |
Protein Sequence |
>4869 : length: 259 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG PSSVEDIKAKMQASIEKAH |