| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 4869 |
Name | NPM1 |
Synonymous | B23|NPM;nucleophosmin (nucleolar phosphoprotein B23, numatrin);NPM1;nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
Definition | nucleolar protein NO38|nucleophosmin|nucleophosmin/nucleoplasmin family, member 1 |
Position | 5q35.1 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
nucleophosmin(h) + p16INK4a-p19(m) <==> nucleophosmin(h):p16INK4a-p19(m) (binding) | nucleophosmin(h) + ATP --> nucleophosmin(h){p} + ADP (phosphorylation) | p16INK4a-p14(h) + nucleophosmin(h) <==> p16INK4a-p14(h):nucleophosmin(h) (binding) | nucleophosmin(mo) + nucleophosmin(h) <==> nucleophosmin(h):nucleophosmin(mo) (binding) | nucleophosmin(h) + nucleolin(mo) <==> nucleophosmin(h):nucleolin(mo) (binding) | nucleophosmin(h) --> p16INK4a-p14(h) (increase of transport) | nucleophosmin(h) --> mdm2(h):p16INK4a-p14(h) (decrease of binding) | nucleophosmin(h) --/ p16INK4a-p14(h) (inhibition) | nucleophosmin(h) + p16INK4a(h) <==> nucleophosmin(h):p16INK4a(h) (binding) | mdm2(h) + nucleophosmin(h) <==> mdm2(h):nucleophosmin(h) (binding) | nucleophosmin(h) + nucleophosmin-Isoform-1(h) <==> nucleophosmin(h):nucleophosmin-Isoform-1(h) (binding) | n sumo1(h) + nucleophosmin(h) --> nucleophosmin(h){sumo}n (sumoylation) | nucleophosmin(h) + n SUMO2(h) --> nucleophosmin(h){sumo2}n (sumoylation) | nucleophosmin(h) + n sumo3(h) --> nucleophosmin(h){sumo3}n (sumoylation) | p16INK4a-xbb1(h) + nucleophosmin(h) <==> p16INK4a-xbb1(h):nucleophosmin(h) (binding) | nucleophosmin(h) + n ubiquitin(h) --BARD1(h):brca1(m.s.)--> nucleophosmin(h){ub}n (ubiquitination) | nucleophosmin(h) + n ubiquitin(h) --E1(rb),Ubc5C(h),BARD1(h):brca1(m.s.)--> nucleophosmin(h){ub}n (ubiquitination) | BARD1(h):brca1(m.s.) + nucleophosmin(h) <==> BARD1(h):brca1(m.s.):nucleophosmin(h) (binding) | BARD1(h) + nucleophosmin(h) <==> BARD1(h):nucleophosmin(h) (binding) | brca1(m.s.) + nucleophosmin(h) <==> brca1(m.s.):nucleophosmin(h) (binding) | nucleophosmin(h) + ctcf(h) <==> nucleophosmin(h):ctcf(h) (binding) | lyar(h) + nucleophosmin(h) <==> lyar(h):nucleophosmin(h) (binding) | USF2(h) + nucleophosmin(h) <==> USF2(h):nucleophosmin(h) (binding) | NPM1(h) --> nucleophosmin(h) (expression). | p16INK4a(h) + nucleophosmin-Isoform-1(h) <==> p16INK4a(h):nucleophosmin-Isoform-1(h) (binding) | nucleophosmin(h) + nucleophosmin-Isoform-1(h) <==> nucleophosmin(h):nucleophosmin-Isoform-1(h) (binding) | n nucleophosmin-Isoform-1(h) <==> (nucleophosmin-Isoform-1(h))n (oligomerization) | NPM1(h) --> nucleophosmin-Isoform-1(h) (expression). | NPM1(h) --> nucleophosmin-Isoform-2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
4 | Phosphoserine. | Swiss-Prot 53.0 | 10 | Phosphoserine. | Swiss-Prot 53.0 | 70 | Phosphoserine. | Swiss-Prot 53.0 | 95 | Phosphothreonine. | Swiss-Prot 53.0 | 106 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 125 | Phosphoserine. | Swiss-Prot 53.0 | 150 | N6-acetyllysine. | Swiss-Prot 53.0 | 154 | N6-acetyllysine. | Swiss-Prot 53.0 | 199 | Phosphothreonine. | Swiss-Prot 53.0 | 212 | N6-acetyllysine. | Swiss-Prot 53.0 | 254 | Phosphoserine. | Swiss-Prot 53.0 | 260 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 234 | Phosphothreonine (CDK1) | 14670079 | Phospho.ELM 6.0 | 237 | Phosphothreonine (CDK1) | 14670079 | Phospho.ELM 6.0 | 199 | Phosphothreonine (CDK1) | 81161106;16083285;15190079;17081983 | Phospho.ELM 6.0 | 17 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 125 | Phosphoserine | 86111864;17081983 | Phospho.ELM 6.0 | 29 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 67 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 70 | Phosphoserine | 16565220;17081983 | Phospho.ELM 6.0 | 219 | Phosphothreonine | 12058066 | Phospho.ELM 6.0 | 4 | Phosphoserine (PLK1) | 15190079;17081983 | Phospho.ELM 6.0 | 95 | Phosphothreonine | 16041368 | Phospho.ELM 6.0 | 254 | Phosphoserine | 16565220;17081983 | Phospho.ELM 6.0 | 10 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr5 |
Promoter: 170745903 - 170747903 | Agilent_014791 |
chr5 |
Promoter: 170745903 - 170747903 | GSE27584 |
chr5 |
Promoter: 170745903 - 170747903 | GSE27584 |
chr5 |
Promoter: 170745903 - 170747903 | GSE27584 |
chr5 |
Promoter: 170745903 - 170747903 | Agilent_014791_44K |