Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4869

Name

NPM1

Synonymous

B23|NPM;nucleophosmin (nucleolar phosphoprotein B23, numatrin);NPM1;nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Definition

nucleolar protein NO38|nucleophosmin|nucleophosmin/nucleoplasmin family, member 1

Position

5q35.1

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

nucleophosmin(h) + p16INK4a-p19(m) <==> nucleophosmin(h):p16INK4a-p19(m) (binding)
nucleophosmin(h) + ATP --> nucleophosmin(h){p} + ADP (phosphorylation)
p16INK4a-p14(h) + nucleophosmin(h) <==> p16INK4a-p14(h):nucleophosmin(h) (binding)
nucleophosmin(mo) + nucleophosmin(h) <==> nucleophosmin(h):nucleophosmin(mo) (binding)
nucleophosmin(h) + nucleolin(mo) <==> nucleophosmin(h):nucleolin(mo) (binding)
nucleophosmin(h) --> p16INK4a-p14(h) (increase of transport)
nucleophosmin(h) --> mdm2(h):p16INK4a-p14(h) (decrease of binding)
nucleophosmin(h) --/ p16INK4a-p14(h) (inhibition)
nucleophosmin(h) + p16INK4a(h) <==> nucleophosmin(h):p16INK4a(h) (binding)
mdm2(h) + nucleophosmin(h) <==> mdm2(h):nucleophosmin(h) (binding)
nucleophosmin(h) + nucleophosmin-Isoform-1(h) <==> nucleophosmin(h):nucleophosmin-Isoform-1(h) (binding)
n sumo1(h) + nucleophosmin(h) --> nucleophosmin(h){sumo}n (sumoylation)
nucleophosmin(h) + n SUMO2(h) --> nucleophosmin(h){sumo2}n (sumoylation)
nucleophosmin(h) + n sumo3(h) --> nucleophosmin(h){sumo3}n (sumoylation)
p16INK4a-xbb1(h) + nucleophosmin(h) <==> p16INK4a-xbb1(h):nucleophosmin(h) (binding)
nucleophosmin(h) + n ubiquitin(h) --BARD1(h):brca1(m.s.)--> nucleophosmin(h){ub}n (ubiquitination)
nucleophosmin(h) + n ubiquitin(h) --E1(rb),Ubc5C(h),BARD1(h):brca1(m.s.)--> nucleophosmin(h){ub}n (ubiquitination)
BARD1(h):brca1(m.s.) + nucleophosmin(h) <==> BARD1(h):brca1(m.s.):nucleophosmin(h) (binding)
BARD1(h) + nucleophosmin(h) <==> BARD1(h):nucleophosmin(h) (binding)
brca1(m.s.) + nucleophosmin(h) <==> brca1(m.s.):nucleophosmin(h) (binding)
nucleophosmin(h) + ctcf(h) <==> nucleophosmin(h):ctcf(h) (binding)
lyar(h) + nucleophosmin(h) <==> lyar(h):nucleophosmin(h) (binding)
USF2(h) + nucleophosmin(h) <==> USF2(h):nucleophosmin(h) (binding)
NPM1(h) --> nucleophosmin(h) (expression).
p16INK4a(h) + nucleophosmin-Isoform-1(h) <==> p16INK4a(h):nucleophosmin-Isoform-1(h) (binding)
nucleophosmin(h) + nucleophosmin-Isoform-1(h) <==> nucleophosmin(h):nucleophosmin-Isoform-1(h) (binding)
n nucleophosmin-Isoform-1(h) <==> (nucleophosmin-Isoform-1(h))n (oligomerization)
NPM1(h) --> nucleophosmin-Isoform-1(h) (expression).
NPM1(h) --> nucleophosmin-Isoform-2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

4Phosphoserine.Swiss-Prot 53.0
10Phosphoserine.Swiss-Prot 53.0
70Phosphoserine.Swiss-Prot 53.0
95Phosphothreonine.Swiss-Prot 53.0
106Phosphoserine (By similarity).Swiss-Prot 53.0
125Phosphoserine.Swiss-Prot 53.0
150N6-acetyllysine.Swiss-Prot 53.0
154N6-acetyllysine.Swiss-Prot 53.0
199Phosphothreonine.Swiss-Prot 53.0
212N6-acetyllysine.Swiss-Prot 53.0
254Phosphoserine.Swiss-Prot 53.0
260Phosphoserine (By similarity).Swiss-Prot 53.0
234Phosphothreonine (CDK1)14670079Phospho.ELM 6.0
237Phosphothreonine (CDK1)14670079Phospho.ELM 6.0
199Phosphothreonine (CDK1)81161106;16083285;15190079;17081983Phospho.ELM 6.0
17Phosphotyrosine (ALK)9819383;11110708Phospho.ELM 6.0
125Phosphoserine86111864;17081983Phospho.ELM 6.0
29Phosphotyrosine (ALK)9819383;11110708Phospho.ELM 6.0
67Phosphotyrosine (ALK)9819383;11110708Phospho.ELM 6.0
70Phosphoserine16565220;17081983Phospho.ELM 6.0
219Phosphothreonine12058066Phospho.ELM 6.0
4Phosphoserine (PLK1)15190079;17081983Phospho.ELM 6.0
95Phosphothreonine16041368Phospho.ELM 6.0
254Phosphoserine16565220;17081983Phospho.ELM 6.0
10Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr5

Promoter: 170745903 - 170747903Agilent_014791

chr5

Promoter: 170745903 - 170747903GSE27584

chr5

Promoter: 170745903 - 170747903GSE27584

chr5

Promoter: 170745903 - 170747903GSE27584

chr5

Promoter: 170745903 - 170747903Agilent_014791_44K


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