| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 51196 |
Name | PLCE1 |
Synonym | NPHS3|PLCE|PPLC;phospholipase C, epsilon 1;PLCE1;phospholipase C, epsilon 1 |
Definition | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1|PLC-epsilon-1|pancreas-enriched phospholipase C|phosphoinositide phospholipase C-epsilon-1|phosphoinositide-specific phospholipase C epsilon-1 |
Position | 10q23 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 1721 |
TUSON P-value | 0.139651968 |
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Pathways and Diseases |
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Pathway | D-myo-inositol (1,4,5)-trisphosphate biosynthesis;BioCyc;PWY-6351 |
Pathway | D-myo-inositol-5-phosphate metabolism;BioCyc;PWY-6367 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Alpha adrenergic receptor signaling pathway;PANTHER;P00002 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | phospholipases;BioCyc;LIPASYN-PWY |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | phospholipase c-epsilon pathway;PID BioCarta;100070 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Disease | Nephrotic syndrome, type 3;OMIM |
Disease | Esophageal cancer and gastric cancer;NHGRI |
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External Links |
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Links to Entrez Gene | 51196 |
Links to all GeneRIF Items | 51196 |
Links to iHOP | 51196 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>51196 : length: 5985 atggtttcagaaggaagtgcagcaggaagagactttgcaggaatggaagaggtgaggcag ctccacgtgagattctgcaaagggattaagatttggcaccaggcttggtttctgtgcagc ctcttaggcagagagccccaggagagggaagcaggctgtcagctgtggctttgcacgctc tcagctgtcttgaaggttggttggctcttcccgctctctgaggtacccaattttaccttg ttaaaggatggatgtggatgctggaggcttaaagaagaccagatctacaatgcagtgaga agagaagaaacagaaaatacagttggatctctactccatttcctcaccaagctcccagcc tccgagacagcccatggaaggataagcgttggtccatgcttaaagcaatgtgtccgagac actgtatgtgagtatcgcgccaccctccaaaggacttcaatatcgcagtacatcaccggt tctctcctagaagcaaccacgtctttgggagcaagaagtggccttctcagtacttttgga ggatccactggacgaatgatgctgaaagaacgccagccaggcccctctgtggccaattcc aatgccctcccttcaagttcagctgggatcagcaaggagctgatcgatctgcagcctctc atccagttcccagaggaagtcgccagcatcctgatggagcaagagcagactatttaccgc agggtcttgccagtcgactacctttgcttcttaacacgggacttgggcactcctgaatgc cagagctccttgccctgcctcaaagcatccatctcagcgtcgattcttaccactcagaat ggagagcacaatgcccttgaagatctggtgatgaggtttaatgaggtgagctcctgggtg acatggctgatcctcacggcaggctccatggaggagaagcgagaagtcttttcatatttg gtgcatgtggccaaatgctgctggaacatgggcaactacaacgctgtcatggagttcttg gctggcctcaggtcaagaaaagttttaaaaatgtggcagttcatggaccagtctgatatt gagaccatgaggagcctgaaggatgctatggcccagcatgagtcctcttgtgagtacaga aaggtggtgacacgtgccctgcacatccctggctgtaaggtggttccattctgtggggtg tttctgaaggagctctgtgaagtgcttgacggcgcctccggtctcatgaagctttgcccg cggtacaattcccaagaagaaactttagagtttgtagcagattacagtggacaagataat ttcttacaacgagtgggacaaaatggcttaaagaattcggagaaggagtccactgtcaac agcatctttcaggtcatccggagctgcaatcgaagtctggagacagacgaggaggacagc cccagtgaaggaaacagctccaggaaaagctccttgaaggataaaagccgatggcagttt ataattggagatttgttggattcagacaatgacatctttgagcaatccaaagaatacgac tctcatggttcagaggactcacagaaggccttcgaccatgggacggagctcatcccttgg tacgtgctgtccatccaagccgatgtgcaccagttcctgctgcagggggccacggtcatc cactacgaccaggacacacacctctctgcccgctgcttcctccagcttcagcccgacaat agcaccttgacctgggtaaagcccacaactgcctccccagccagcagtaaagcaaaactt ggtgtacttaataacacagctgagcctggaaaattcccactactgggtaatgctggatta agtagcctgacggaaggggtcttggatctttttgcagtgaaggctgtatacatgggccac cctggcattgatatacacactgtgtgtgttcagaacaaactgggtagcatgttcctgtca gagactggtgtgacattgctctatgggcttcagaccacagacaacagattattgcacttc gtggcaccaaagcacacagctaaaatgctcttcagcggattattggaactcactagagct gtgagaaagatgaggaaattccctgaccaaagacagcagtggctgcggaaacagtacgtc agcctttatcaggaggatggacggtatgaaggcccaactttggctcacgctgtggagttg tttggtggcagacggtggagtgctcgaaaccccagccccggaacatcagcaaagaatgct gagaagcccaatatgcagagaaacaataccctgggcataagcactaccaagaaaaagaag aaaatcctcatgaggggtgagagtggagaggtaactgacgatgagatggcaacccgaaag gccaagatgcacaaagagtgtcgaagccggagtggttctgatcctcaagacattaatgaa caagaagaatcagaggtgaatgccatcgctaaccctccaaaccccctcccttccagaaga gcccactctttgaccacagctgggtcccccaacttggctgccgggacgtcatctcccatc aggccagtgtcctcccctgtgctgtcttcttcaaacaagagcccatccagtgcttggagc agtagtagctggcacgggcggatcaaaggcggcatgaagggatttcagagcttcatggtt tcagatagcaacatgagttttgttgaatttgttgagctgttcaaatcattcagtgtcagg agccgcaaggacctgaaggatctgtttgatgtctatgcagtgccctgcaaccgatctggc tccgagtcagccccactctacaccaacctgacaattgatgaaaacaccagcgatcttcag cctgacctagatctgttgaccagaaatgtctcggatttggggttgttcattaagagtaaa cagcagctatcggacaaccagaggcagatatctgatgccattgctgctgcaagcattgtg acaaatggcactgggattgagagcacatctctgggcatttttggggtgggcatacttcag ctcaacgatttcctcgtgaattgccaaggagaacactgcacttatgatgaaatcctcagc atcatccagaagttcgagcctagcatcagtatgtgtcatcagggactaatgtcatttgaa gggtttgccaggtttctgatggataaagaaaattttgcctcaaaaaatgatgagtcacag gagaacattaaagaactgcagctacccctctcatactattacatcgaatcttcgcacaat acctacctcacgggccatcagctcaaaggagaatcctcggtagaactctacagccaggtc cttttgcaaggctgtcgaagtgtagaattggactgctgggacggagacgatgggatgccc atcatttatcatggacatacgctgacaaccaagatccccttcaaggaagtggttgaagcc attgatcgcagtgccttcatcaactctgacctgccaatcatcatatcgattgagaaccac tgttcattgcctcagcaacgaaaaatggcagaaattttcaagactgtgtttggagaaaag ctggtgactaaattcttatttgagactgatttctcagatgatccaatgcttccttcacct gaccaactcagaaagaaagttcttcttaaaaacaagaagctaaaagcccatcagacgcca gtggatatcttaaagcaaaaggctcatcagttagcatctatgcaagtgcaggcttataat ggtgggaatgccaacccccgacctgccaataatgaggaagaggaagatgaggaggacgaa tatgattatgactatgaatccctttctgatgacaacattctggaagacagacctgaaaat aaatcatgtaatgacaagcttcagtttgaatataatgaagaaatcccaaagaggataaag aaagcagataactctgcttgcaacaaaggaaaggtttatgatatggaactgggagaagaa ttttatcttgatcagaataaaaaggaaagcagacagattgcaccagagctttctgacctt gtaatctattgtcaagcagtaaaatttccaggactgtcaactctaaatgcatctggctct agcagaggaaaagaaaggaaaagcaggaagtccatttttggcaacaatccgggcagaatg agcccaggggagacagcatcatttaacaaaacatctggaaaaagttcctgtgaaggcatt cgacagacctgggaggaatcttcttcccctctcaacccaaccacgtccctcagtgctatc attagaactcccaaatgttatcatatctcgtcgctgaatgaaaatgccgccaaacgtctg tgtcgcaggtattctcagaaactgacccagcacaccgcctgtcagctgctgagaacttac cctgctgccacccgcatcgactcttccaacccgaaccccctcatgttctggctccatggg atacagcttgtggcactcaactaccagactgatgatctccctttacatttaaatgctgca atgtttgaggcaaatggtggttgtggttatgtattgaaacctccagttctgtgggacaag aactgccccatgtatcagaagttttctccactagaaagagatctggacagcatggatcct gcagtctattctttaactattgtctctggtcagaatgtgtgccccagtaatagcatggga agcccgtgcattgaagtcgacgtcctgggcatgcctctggacagctgccatttccgcaca aagcccatccatcgaaacaccctgaaccccatgtggaacgagcagtttctgttccacgtt cacttcgaagatcttgtatttcttcgttttgcagttgtggaaaacaatagttcagcggta actgctcagagaatcattccactgaaagctttaaaacgaggatatcgacatcttcagctg cgaaaccttcacaatgaagtcttggagatttctagtttattcattaacagcagaaggatg gaagaaaattcctctggcaataccatgtcagcctcttcgatgtttaatacagaagaaaga aaatgtttgcagactcacagagtcacggtgcatggggtcccagggccagagccctttacc gttttcactattaatggaggcaccaaggcaaagcagcttctgcagcaaattctgacaaat gaacaagacatcaaacctgttaccacagactattttttgatggaagaaaaatattttata tctaaagaaaagaatgaatgtaggaaacaaccattccagagagccattggtccagaagag gagatcatgcaaattttaagcagctggtttccagaagagggatacatgggcaggattgtc ttaaaaacccagcaggaaaacctagaagagaaaaacattgttcaagatgacaaagaggtg atcttgagctcagaggaggagagtttctttgtccaagtgcatgatgtttctccagagcaa cctcgaacagtcatcaaagcaccccgcgtcagcactgcacaggatgtcattcagcagacc ttatgcaaagccaaatattcctacagcatcctgagcaaccccaatccaagcgactatgtg cttttggaagaggtggtgaaagacactaccaacaagaagactaccacaccaaagtcctct cagcgggtccttctggatcaggagtgtgtgtttcaagcccaaagcaagtggaaaggtgca ggaaaattcatccttaagctaaaggagcaggtgcaggcatctcgagaagataaaaagaaa ggcatttctttcgcaagtgaactcaagaagctcaccaagtcaactaaacagccccgagga cttacatcaccttctcagctcttgacctcagaaagtatccaaaccaaggaggagaaacct gtgggtggcttgtcctccagtgacacaatggattaccgacagtga |
Protein Sequence |
>51196 : length: 1994 MVSEGSAAGRDFAGMEEVRQLHVRFCKGIKIWHQAWFLCSLLGREPQEREAGCQLWLCTL SAVLKVGWLFPLSEVPNFTLLKDGCGCWRLKEDQIYNAVRREETENTVGSLLHFLTKLPA SETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFG GSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYR RVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWV TWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDI ETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCP RYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDEEDS PSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFDHGTELIPW YVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKL GVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLS ETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYV SLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGISTTKKKK KILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRR AHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFMV SDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQ PDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQ LNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQ ENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMP IIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEK LVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYN GGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIK KADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGS SRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAI IRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHG IQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDP AVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHV HFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRM EENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTN EQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIV LKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQT LCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGA GKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKP VGGLSSSDTMDYRQ |