| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5371 |
Name | PML |
Synonym | MYL|PP8675|RNF71|TRIM19;promyelocytic leukemia;PML;promyelocytic leukemia |
Definition | RING finger protein 71|probable transcription factor PML|promyelocytic leukemia protein|promyelocytic leukemia, inducer of|protein PML|tripartite motif protein TRIM19|tripartite motif-containing protein 19 |
Position | 15q22 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 12995 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | regulation of transcriptional activity by pml;PID BioCarta;100067 |
Pathway | C-MYC pathway;PID Curated;200093 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Height;NHGRI |
Disease | Cancers;KEGG DISEASE |
Disease | Gallbaldder cancer;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Acute myeloid leukemia (AML);KEGG DISEASE;H00003 |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | Rheumatoid arthritis;FunDO |
Disease | Cytomegalovirus infection;FunDO |
Disease | Leukemia;FunDO |
Disease | Neuroblastoma;FunDO |
Disease | Leukemia, acute promyelocytic, PML/RARA type;OMIM |
Disease | Breast cancer;FunDO |
Disease | Leukoencephalopathy;FunDO |
Disease | Liver cancer;FunDO |
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External Links |
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Links to Entrez Gene | 5371 |
Links to all GeneRIF Items | 5371 |
Links to iHOP | 5371 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5371 : length: 1902 atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa agtgggttctcctggggctacccccacccctttctaatttag |
Protein Sequence |
>5371 : length: 633 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL ADPQAEDRPLVFFDLKIDNESGFSWGYPHPFLI |