Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5371

Name

PML

Synonymous

MYL|PP8675|RNF71|TRIM19;promyelocytic leukemia;PML;promyelocytic leukemia

Definition

RING finger protein 71|probable transcription factor PML|promyelocytic leukemia protein|promyelocytic leukemia, inducer of|protein PML|tripartite motif protein TRIM19|tripartite motif-containing protein 19

Position

15q22

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

hipk2(h) + PML-3(h) <==> hipk2(h):PML-3(h) (binding)
PML-3(h) + p53(h) <==> PML-3(h):p53(h) (binding)
SNURF(r) + PML-3(h) <==> SNURF(r):PML-3(h) (binding)
PML(h) --> PML-3(h) (expression).
PML(h) + mdm2(h) <==> PML(h):mdm2(h) (binding)
PML(h) + p73alpha(h) <==> PML(h):p73alpha(h) (binding)
eIF-4E(m.s.) + PML(h) <==> eIF-4E(m.s.):PML(h) (binding)
eIF-4E(h) + PML(h) <==> eIF-4E(h):PML(h) (binding)
eIF-4E(m) + PML(h) <==> eIF-4E(m):PML(h) (binding)
PML(h) --/ cyclinD1(m) (inhibition)
Hex(m.s.) + PML(h) <==> Hex(m.s.):PML(h) (binding)
PML(h) + GAPD(h) <==> PML(h):GAPD(h) (binding)
GATA-2(h) + PML(h) <==> GATA-2(h):PML(h) (binding)
NCOR(h) + PML(h) <==> NCOR(h):PML(h) (binding)
sin3a(h) + PML(h) <==> sin3a(h):PML(h) (binding)
HDAC1(h) + PML(h) <==> HDAC1(h):PML(h) (binding)
PML(h) + c-Ski(h) <==> PML(h):c-Ski(h) (binding)
NR1B1(h) + PML(h) <==> NR1B1(h):PML(h) (binding)
c-Jun(h) + PML(h) <==> c-Jun(h):PML(h) (binding)
PML(h) + Smad2(m.s.) <==> PML(h):Smad2(m.s.) (binding)
Smad3(h) + PML(h) <==> Smad3(h):PML(h) (binding)
PML(h) + SARA(m.s.) <==> PML(h):SARA(m.s.) (binding)
PML(h) + Smad3(h) + SARA(m.s.) <==> PML(h):Smad3(h):SARA(m.s.) (binding)
PML(h) + TGFbetaR-I(m.s.) <==> PML(h):TGFbetaR-I(m.s.) (binding)
PML(h) + TGFbetaR-II(m.s.) <==> PML(h):TGFbetaR-II(m.s.) (binding)
Daxx(h) + PML(h) <==> Daxx(h):PML(h) (binding)
Daxx(h) + PML(h) <==> Daxx(h):PML(h) (binding)
PML(h) + sumo1(m.s.) --> PML(h){sumo} (sumoylation)
PML(h) + c-Myc(m) <==> PML(h):c-Myc(m) (binding)
PML(h) + c-Myc(m) <==> PML(h):c-Myc(m) (binding)
PML(h) + c-Myc(m.s.) <==> PML(h):c-Myc(m.s.) (binding)
PML(h) + sumo1(h) --> PML(h){sumo} (sumoylation)
PML(h) --> PML(h) (translocation)
ZNF198(m.s.) + PML(h) <==> ZNF198(m.s.):PML(h) (binding)
sumo1(h) + PML(h) <==> sumo1(h):PML(h) (binding)
ZNF198(h) + PML(h) <==> ZNF198(h):PML(h) (binding)
PML(h) + SUMO2(h) --> PML(h){sumo2} (sumoylation)
PML(h) + Daxx(m) <==> PML(h):Daxx(m) (binding)
Hex(h) + PML(h) <==> Hex(h):PML(h) (binding)
Pin1(h) + PML(h) <==> Pin1(h):PML(h) (binding)
PML(h) --> PML(h) (expression).
PML(h) --> PML(h) (translocation)
IFNgamma(h) --> PML(h) (increase of abundance)
IFNalpha(m.s.) --> PML(h) (increase of abundance)
IFNalpha2b(h) --> PML(h) (increase of abundance)
PML(h) --> PML-1(h) (expression).
TIF1(m) + PML-2(h) <==> TIF1(m):PML-2(h) (binding)
PML-2(h) + CBP(m.s.) <==> PML-2(h):CBP(m.s.) (binding)
PML(h) --> PML-2(h) (expression).
PML(h) --> PML-3B(h) (expression).
PML-X(h) + ATP --ATR(h)--> ADP + PML(h){p} (phosphorylation)
PML-X(h) + mdm2(h) <==> PML-X(h):mdm2(h) (binding)
PML-X(h) + mdm2(m) <==> PML-X(h):mdm2(m) (binding)
PML-X(h) + rpl11(m) <==> PML-X(h):rpl11(m) (binding)
PML-X(h) + rpl11(h) <==> PML-X(h):rpl11(h) (binding)
HDAC3(m.s.) + PML-X(h) <==> HDAC3(m.s.):PML-X(h) (binding)
HDAC1(m.s.) + PML-X(h) <==> HDAC1(m.s.):PML-X(h) (binding)
HDAC3(h) + PML-X(h) <==> HDAC3(h):PML-X(h) (binding)
hdac2(m.s.) + PML-X(h) <==> hdac2(m.s.):PML-X(h) (binding)
PML(h) --> PML-X(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

8Phosphoserine.Swiss-Prot 53.0
403Phosphoserine.Swiss-Prot 53.0
504Phosphoserine (By similarity).Swiss-Prot 53.0
505Phosphoserine (By similarity).Swiss-Prot 53.0
518Phosphoserine.Swiss-Prot 53.0
527Phosphoserine.Swiss-Prot 53.0
530Phosphoserine.Swiss-Prot 53.0
535Phosphoserine.Swiss-Prot 53.0
560Phosphoserine.Swiss-Prot 53.0
561Phosphoserine.Swiss-Prot 53.0
562Phosphoserine.Swiss-Prot 53.0
565Phosphoserine.Swiss-Prot 53.0
530Phosphoserine17081983Phospho.ELM 6.0
578Phosphoserine17081983Phospho.ELM 6.0
579Phosphoserine17081983Phospho.ELM 6.0
580Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584

chr15

Promoter: 72072567 - 72074567GSE27584


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