| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 545 |
Name | ATR |
Synonym | FCTCS|FRP1|MEC1|SCKL|SCKL1;ATR serine/threonine kinase;ATR;ATR serine/threonine kinase |
Definition | FRAP-related protein-1|MEC1, mitosis entry checkpoint 1, homolog|ataxia telangiectasia and Rad3-related protein|serine/threonine-protein kinase ATR |
Position | 3q23 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 276 |
TUSON P-value | 0.002291634 |
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Pathways and Diseases |
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Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | Circadian rhythm pathway;PID Curated;200068 |
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | p53 pathway;PID Curated;200175 |
Disease | Cancers;KEGG DISEASE |
Disease | Fanconi's anemia;FunDO |
Disease | Cancers of soft tissues and bone;KEGG DISEASE |
Disease | Endometrial Neoplasms;GAD |
Disease | Carcinoma, Endometrioid;GAD |
Disease | CANCER;GAD |
Disease | Alveolar rhabdomyosarcoma;KEGG DISEASE;H00037 |
Disease | Cancer;FunDO |
Disease | Seckel syndrome 1;OMIM |
Disease | Microsatellite Instability;GAD |
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External Links |
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Links to Entrez Gene | 545 |
Links to all GeneRIF Items | 545 |
Links to iHOP | 545 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>545 : length: 7935 atgggggaacatggcctggagctggcttccatgatccccgccctgcgggagctgggcagt gccacaccagaggaatataatacagttgtacagaagccaagacaaattctgtgtcaattc attgaccggatacttacagatgtaaatgttgttgctgtagaacttgtaaagaaaactgac tctcagccaacctccgtgatgttgcttgatttcatccagcatatcatgaaatcctcccca cttatgtttgtaaatgtgagtggaagccatgaggccaaaggcagttgtattgaattcagt aattggatcataacgagacttctgcggattgcagcaactccctcctgtcatttgttacac aagaaaatctgtgaagtcatctgttcattattatttctttttaaaagcaagagtcctgct atttttggggtactcacaaaagaattattacaactttttgaagacttggtttacctccat agaagaaatgtgatgggtcatgctgtggaatggccagtggtcatgagccgatttttaagt caattagatgaacacatgggatatttacaatcagctcctttgcagttgatgagtatgcaa aatttagaatttattgaagtcactttattaatggttcttactcgtattattgcaattgtg ttttttagaaggcaagaactcttactttggcagataggttgtgttctgctagagtatggt agtccaaaaattaaatccctagcaattagctttttaacagaactttttcagcttggagga ctaccagcacaaccagctagcacttttttcagctcatttttggaattattaaaacacctt gtagaaatggatactgaccaattgaaactctatgaagagccattatcaaagctgataaag acactatttccctttgaagcagaagcttatagaaatattgaacctgtctatttaaatatg ctgctggaaaaactctgtgtcatgtttgaagacggtgtgctcatgcggcttaagtctgat ttgctaaaagcagctttgtgccatttactgcagtatttccttaaatttgtgccagctggg tatgaatctgctttacaagtcaggaaggtctatgtgagaaatatttgtaaagctcttttg gatgtgcttggaattgaggtagatgcagagtacttgttgggcccactttatgcagctttg aaaatggaaagtatggaaatcattgaggagattcaatgccaaactcaacaggaaaacctc agcagtaatagtgatggaatatcacccaaaaggcgtcgtctcagctcgtctctaaaccct tctaaaagagcaccaaaacagactgaggaaattaaacatgtggacatgaaccaaaagagc atattatggagtgcactgaaacagaaagctgaatcccttcagatttcccttgaatacagt ggcctaaagaatcctgttattgagatgttagaaggaattgctgttgtcttacaactgact gctctgtgtactgttcattgttctcatcaaaacatgaactgccgtactttcaaggactgt caacataaatccaagaagaaaccttctgtagtgataacttggatgtcattggatttttac acaaaagtgcttaagagctgtagaagtttgttagaatctgttcagaaactggacctggag gcaaccattgataaggtggtgaaaatttatgatgctttgatttatatgcaagtaaacagt tcatttgaagatcatatcctggaagatttatgtggtatgctctcacttccatggatttat tcccattctgatgatggctgtttaaagttgaccacatttgccgctaatcttctaacatta agctgtaggatttcagatagctattcaccacaggcacaatcacgatgtgtgtttcttctg actctgtttccaagaagaatattccttgagtggagaacagcagtttacaactgggccctg cagagctcccatgaagtaatccgggctagttgtgttagtggattttttatcttattgcag cagcagaattcttgtaacagagttcccaagattcttatagataaagtcaaagatgattct gacattgtcaagaaagaatttgcttctatacttggtcaacttgtctgtactcttcacggc atgttttatctgacaagttctttaacagaacctttctctgaacacggacatgtggacctc ttctgtaggaacttgaaagccacttctcaacatgaatgttcatcttctcaactaaaagct tctgtctgcaagccattccttttcctactgaaaaaaaaaatacctagtccagtaaaactt gctttcatagataatctacatcatctttgtaagcatcttgattttagagaagatgaaaca gatgtaaaagcagttcttggaactttattaaatttaatggaagatccagacaaagatgtt agagtggcttttagtggaaatatcaagcacatattggaatccttggactctgaagatgga tttataaaggagctttttgtcttaagaatgaaggaagcatatacacatgcccaaatatca agaaataatgagctgaaggataccttgattcttacaacaggggatattggaagggccgca aaaggagatttggtaccatttgcactcttacacttattgcattgtttgttatccaagtca gcatctgtctctggagcagcatacacagaaattagagctctggttgcagctaaaagtgtt aaactgcaaagttttttcagccagtataagaaacccatctgtcagtttttggtagaatcc cttcactctagtcagatgacagcacttccgaatactccatgccagaatgctgacgtgcga aaacaagatgtggctcaccagagagaaatggctttaaatacgttgtctgaaattgccaac gttttcgactttcctgatcttaatcgttttcttactaggacattacaagttctactacct gatcttgctgccaaagcaagccctgcagcttctgctctcattcgaactttaggaaaacaa ttaaatgtcaatcgtagagagattttaataaacaacttcaaatatattttttctcatttg gtctgttcttgttccaaagatgaattagaacgtgcccttcattatctgaagaatgaaaca gaaattgaactggggagcctgttgagacaagatttccaaggattgcataatgaattattg ctgcgtattggagaacactatcaacaggtttttaatggtttgtcaatacttgcctcattt gcatccagtgatgatccatatcagggcccgagagatatcatatcacctgaactgatggct gattatttacaacccaaattgttgggcattttggctttttttaacatgcagttactgagc tctagtgttggcattgaagataagaaaatggccttgaacagtttgatgtctttgatgaag ttaatgggacccaaacatgtcagttctgtgagggtgaagatgatgaccacactgagaact ggccttcgattcaaggatgattttcctgaattgtgttgcagagcttgggactgctttgtt cgctgcctggatcatgcttgtctgggctcccttctcagtcatgtaatagtagctttgtta cctcttatacacatccagcctaaagaaactgcagctatcttccactacctcataattgaa aacagggatgctgtgcaagattttcttcatgaaatatattttttacctgatcatccagaa ttaaaaaagataaaagccgttctccaggaatacagaaaggagacctctgagagcactgat cttcagacaactcttcagctctctatgaaggccattcaacatgaaaatgtcgatgttcgt attcatgctcttacaagcttgaaggaaaccttgtataaaaatcaggaaaaactgataaag tatgcaacagacagtgaaacagtagaacctattatctcacagttggtgacagtgcttttg aaaggttgccaagatgcaaactctcaagctcggttgctctgtggggaatgtttaggggaa ttgggggcgatagatccaggtcgattagatttctcaacaactgaaactcaaggaaaagat tttacatttgtgactggagtagaagattcaagctttgcctatggattattgatggagcta acaagagcttaccttgcgtatgctgataatagccgagctcaagattcagctgcctatgcc attcaggagttgctttctatttatgactgtagagagatggagaccaacggcccaggtcac caattgtggaggagatttcctgagcatgttcgggaaatactagaacctcatctaaatacc agatacaagagttctcagaagtcaaccgattggtctggagtaaagaagccaatttactta agtaaattgggtagtaactttgcagaatggtcagcatcttgggcaggttatcttattaca aaggttcgacatgatcttgccagtaaaattttcacctgctgtagcattatgatgaagcat gatttcaaagtgaccatctatcttcttccacatattctggtgtatgtcttactgggttgt aatcaagaagatcagcaggaggtttatgcagaaattatggcagttctaaagcatgacgat cagcataccataaatacccaagacattgcatctgatctgtgtcaactcagtacacagact gtgttctccatgcttgaccatctcacacagtgggcaaggcacaaatttcaggcactgaaa gctgagaaatgtccacacagcaaatcaaacagaaataaggtagactcaatggtatctact gtggattatgaagactatcagagtgtaacccgttttctagacctcataccccaggatact ctggcagtagcttcctttcgctccaaagcatacacacgagctgtaatgcactttgaatca tttattacagaaaagaagcaaaatattcaggaacatcttggatttttacagaaattgtat gctgctatgcatgaacctgatggagtggccggagtcagtgcaattagaaaggcagaacca tctctaaaagaacagatccttgaacatgaaagccttggcttgctgagggatgccactgct tgttatgacagggctattcagctagaaccagaccagatcattcattatcatggtgtagta aagtccatgttaggtcttggtcagctgtctactgttatcactcaggtgaatggagtgcat gctaacaggtccgagtggacagatgaattaaacacgtacagagtggaagcagcttggaaa ttgtcacagtgggatttggtggaaaactatttggcagcagatggaaaatctacaacatgg agtgtcagactgggacagctattattatcagccaaaaaaagagatatcacagctttttat gactcactgaaactagtgagagcagaacaaattgtacctctttcagctgcaagctttgaa agaggctcctaccaacgaggatatgaatatattgtgagattgcacatgttatgtgagttg gagcatagcatcaaaccacttttccagcattctccaggtgacagttctcaagaagattct ctaaactgggtagctcgactagaaatgacccagaattcctacagagccaaggagcctatc ctggctctccggagggctttactaagcctcaacaaaagaccagattacaatgaaatggtt ggagaatgctggctgcagagtgccagggtagctagaaaggctggtcaccaccagacagcc tacaatgctctccttaatgcaggggaatcacgactcgctgaactgtacgtggaaagggca aagtggctctggtccaagggtgatgttcaccaggcactaattgttcttcaaaaaggtgtt gaattatgttttcctgaaaatgaaaccccacctgagggtaagaacatgttaatccatggt cgagctatgctactagtgggccgatttatggaagaaacagctaactttgaaagcaatgca attatgaaaaaatataaggatgtgaccgcgtgcctgccagaatgggaggatgggcatttt taccttgccaagtactatgacaaattgatgcccatggtcacagacaacaaaatggaaaag caaggtgatctcatccggtatatagttcttcattttggcagatctctacaatatggaaat cagttcatatatcagtcaatgccacgaatgttaactctatggcttgattatggtacaaag gcatatgaatgggaaaaagctggccgctccgatcgtgtacaaatgaggaatgatttgggt aaaataaacaaggttatcacagagcatacaaactatttagctccatatcaatttttgact gctttttcacaattgatctctcgaatttgtcattctcacgatgaagtttttgttgtcttg atggaaataatagccaaagtatttctagcctatcctcaacaagcaatgtggatgatgaca gctgtgtcaaagtcatcttatcccatgcgtgtgaacagatgcaaggaaatcctcaataaa gctattcatatgaaaaaatccttagagaagtttgttggagatgcaactcgcctaacagat aagcttctagaattgtgcaataaaccggttgatggaagtagttccacattaagcatgagc actcattttaaaatgcttaaaaagctggtagaagaagcaacatttagtgaaatcctcatt cctctacaatcagtcatgatacctacacttccatcaattctgggtacccatgctaaccat gctagccatgaaccatttcctggacattgggcctatattgcagggtttgatgatatggtg gaaattcttgcttctcttcagaaaccaaagaagatttctttaaaaggctcagatggaaag ttctacatcatgatgtgtaagccaaaagatgacctgagaaaggattgtagactaatggaa ttcaattccttgattaataagtgcttaagaaaagatgcagagtctcgtagaagagaactt catattcgaacatatgcagttattccactaaatgatgaatgtgggattattgaatgggtg aacaacactgctggtttgagacctattctgaccaaactatataaagaaaagggagtgtat atgacaggaaaagaacttcgccagtgtatgctaccaaagtcagcagctttatctgaaaaa ctcaaagtattccgagaatttctcctgcccaggcatcctcctatttttcatgagtggttt ctgagaacattccctgatcctacatcatggtacagtagtagatcagcttactgccgttcc actgcagtaatgtcaatggttggttatattctggggcttggagaccgtcatggtgaaaat attctctttgattctttgactggtgaatgcgtacatgtagatttcaattgtcttttcaat aagggagaaacctttgaagttccagaaattgtgccatttcgcctgactcataatatggtt aatggaatgggtcctatgggaacagagggtctttttcgaagagcatgtgaagttacaatg aggctgatgcgtgatcagcgagagcctttaatgagtgtcttaaagacttttctacatgat cctcttgtggaatggagtaaaccagtgaaagggcattccaaagcgccactgaatgaaact ggagaagttgtcaatgaaaaggccaagacccatgttcttgacattgagcagcgactacaa ggtgtaatcaagactcgaaatagagtgacaggactgccgttatctattgaaggacatgtg cattaccttatacaggaagctactgatgaaaacttactatgccagatgtatcttggttgg actccatatatgtga |
Protein Sequence |
>545 : length: 2644 MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW TPYM |