| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 545 |
Name | ATR |
Synonymous | FCTCS|FRP1|MEC1|SCKL|SCKL1;ATR serine/threonine kinase;ATR;ATR serine/threonine kinase |
Definition | FRAP-related protein-1|MEC1, mitosis entry checkpoint 1, homolog|ataxia telangiectasia and Rad3-related protein|serine/threonine-protein kinase ATR |
Position | 3q23 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
p300(h) + ATR(h) <==> p300(h):ATR(h) (binding) | ATR(h) --> ATM(h){pS1981} (increase of phosphorylation) | ATR(h) + brca1(h) <==> ATR(h):brca1(h) (binding) | ATR(h) + ATP --> ATR(h){p} + ADP (phosphorylation) | ATR(h) + TIF2(h) <==> ATR(h):TIF2(h) (binding) | ATR(h) --> ATR(h) (expression). | Chk1(h) + ATP --ATR(h)--> Chk1(h){p} + ADP (phosphorylation) | p53(h) + ATP --ATR(h)--> p53(h){pS15} + ADP (phosphorylation) | PML-X(h) + ATP --ATR(h)--> ADP + PML(h){p} (phosphorylation) | Bid(m) + 2 ATP --ATR(h)--> Bid(m){pS61}{pS78} + 2 ADP (phosphorylation) | Chk1(h) + ATP --ATR(h)--> Chk1(h){pS345} + ADP (phosphorylation) | brca1(h) + ATP --ATR(h)--> brca1(h){p} + ADP (phosphorylation) | ATR(h) + ATP --ATR(m.s.)--> ATR(h){pS1333} + ADP (phosphorylation; automodification) | ATR(h) --> ATR(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
1989 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr3 |
Promoter: 143779841 - 143781841 | Agilent_014791 |
chr3 |
Promoter: 143779841 - 143781841 | GSE27584 |
chr3 |
Promoter: 143779841 - 143781841 | Agilent_014791_44K |
chr3 |
Promoter: 143779841 - 143781841 | Agilent_014791 |